Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QCA

CryoEM structure of a S. Cerevisiae Ski2387 complex in the closed state bound to RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000956	biological_process	nuclear-transcribed mRNA catabolic process
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003729	molecular_function	mRNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006401	biological_process	RNA catabolic process
A	0006402	biological_process	mRNA catabolic process
A	0006417	biological_process	regulation of translation
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0051607	biological_process	defense response to virus
A	0055087	cellular_component	Ski complex
A	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
A	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
B	0000956	biological_process	nuclear-transcribed mRNA catabolic process
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006401	biological_process	RNA catabolic process
B	0006402	biological_process	mRNA catabolic process
B	0051607	biological_process	defense response to virus
B	0055087	cellular_component	Ski complex
B	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
B	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
C	0000228	cellular_component	nuclear chromosome
C	0000956	biological_process	nuclear-transcribed mRNA catabolic process
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0006402	biological_process	mRNA catabolic process
C	0007131	biological_process	reciprocal meiotic recombination
C	0032991	cellular_component	protein-containing complex
C	0051321	biological_process	meiotic cell cycle
C	0051607	biological_process	defense response to virus
C	0055087	cellular_component	Ski complex
C	0065003	biological_process	protein-containing complex assembly
C	0065004	biological_process	protein-DNA complex assembly
C	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
C	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
D	0000228	cellular_component	nuclear chromosome
D	0000956	biological_process	nuclear-transcribed mRNA catabolic process
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0006402	biological_process	mRNA catabolic process
D	0007131	biological_process	reciprocal meiotic recombination
D	0032991	cellular_component	protein-containing complex
D	0051321	biological_process	meiotic cell cycle
D	0051607	biological_process	defense response to virus
D	0055087	cellular_component	Ski complex
D	0065003	biological_process	protein-containing complex assembly
D	0065004	biological_process	protein-DNA complex assembly
D	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
D	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. TVSCsgDgYLKVWDN

Chain	Residue	Details
C	THR29-ASN43
C	LEU306-VAL320

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	177
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	33
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	33
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	31
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	33
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	68
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	62
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	44
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	52
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	46
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	33
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)