8QC4

M. tuberculosis salicylate synthase MbtI in complex with 5-(3-carboxyphenyl)furan-2-carboxylic acid

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	tryptophan biosynthetic process
A	0000287	molecular_function	magnesium ion binding
A	0004106	molecular_function	chorismate mutase activity
A	0005886	cellular_component	plasma membrane
A	0008909	molecular_function	isochorismate synthase activity
A	0009058	biological_process	biosynthetic process
A	0009697	biological_process	salicylic acid biosynthetic process
A	0010106	biological_process	cellular response to iron ion starvation
A	0016829	molecular_function	lyase activity
A	0016833	molecular_function	oxo-acid-lyase activity
A	0016853	molecular_function	isomerase activity
A	0019540	biological_process	catechol-containing siderophore biosynthetic process
A	0043904	molecular_function	isochorismate pyruvate lyase activity
A	0046872	molecular_function	metal ion binding
A	0052572	biological_process	response to host immune response
B	0000162	biological_process	tryptophan biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004106	molecular_function	chorismate mutase activity
B	0005886	cellular_component	plasma membrane
B	0008909	molecular_function	isochorismate synthase activity
B	0009058	biological_process	biosynthetic process
B	0009697	biological_process	salicylic acid biosynthetic process
B	0010106	biological_process	cellular response to iron ion starvation
B	0016829	molecular_function	lyase activity
B	0016833	molecular_function	oxo-acid-lyase activity
B	0016853	molecular_function	isomerase activity
B	0019540	biological_process	catechol-containing siderophore biosynthetic process
B	0043904	molecular_function	isochorismate pyruvate lyase activity
B	0046872	molecular_function	metal ion binding
B	0052572	biological_process	response to host immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q9X9I8

Chain	Residue	Details
A	GLU252
B	GLU252

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20512795, ECO:0000269|PubMed:22607697

Chain	Residue	Details
A	GLY270
B	GLY270

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20512795

Chain	Residue	Details
A	GLU297
A	GLU431
A	GLU434
B	GLU297
B	GLU431
B	GLU434

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site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:16923875, ECO:0000269|PubMed:20512795, ECO:0000269|PubMed:22607697

Chain	Residue	Details
A	TYR385
A	ARG405
A	GLY419
A	LYS438
B	TYR385
B	ARG405
B	GLY419
B	LYS438

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Could activate a water molecule for attack at the C2 of chorismate and involved in recognition/elimination of the C4 hydroxyl => ECO:0000269|PubMed:17240979

Chain	Residue	Details
A	LEU268
B	LEU268

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