Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QBD

Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005811	cellular_component	lipid droplet
A	0005886	cellular_component	plasma membrane
A	0006897	biological_process	endocytosis
A	0008104	biological_process	intracellular protein localization
A	0008289	molecular_function	lipid binding
A	0032126	cellular_component	eisosome
A	0036286	cellular_component	eisosome filament
A	0070941	biological_process	eisosome assembly
A	0071944	cellular_component	cell periphery
A	0097446	biological_process	protein localization to eisosome filament
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005811	cellular_component	lipid droplet
B	0005886	cellular_component	plasma membrane
B	0006897	biological_process	endocytosis
B	0008104	biological_process	intracellular protein localization
B	0008289	molecular_function	lipid binding
B	0032126	cellular_component	eisosome
B	0036286	cellular_component	eisosome filament
B	0070941	biological_process	eisosome assembly
B	0071944	cellular_component	cell periphery
B	0097446	biological_process	protein localization to eisosome filament
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005811	cellular_component	lipid droplet
C	0005886	cellular_component	plasma membrane
C	0006897	biological_process	endocytosis
C	0008104	biological_process	intracellular protein localization
C	0008289	molecular_function	lipid binding
C	0032126	cellular_component	eisosome
C	0036286	cellular_component	eisosome filament
C	0070941	biological_process	eisosome assembly
C	0071944	cellular_component	cell periphery
C	0097446	biological_process	protein localization to eisosome filament
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005811	cellular_component	lipid droplet
D	0005886	cellular_component	plasma membrane
D	0006897	biological_process	endocytosis
D	0008104	biological_process	intracellular protein localization
D	0008289	molecular_function	lipid binding
D	0032126	cellular_component	eisosome
D	0036286	cellular_component	eisosome filament
D	0070941	biological_process	eisosome assembly
D	0071944	cellular_component	cell periphery
D	0097446	biological_process	protein localization to eisosome filament
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005811	cellular_component	lipid droplet
E	0005886	cellular_component	plasma membrane
E	0006897	biological_process	endocytosis
E	0008104	biological_process	intracellular protein localization
E	0008289	molecular_function	lipid binding
E	0032126	cellular_component	eisosome
E	0036286	cellular_component	eisosome filament
E	0070941	biological_process	eisosome assembly
E	0071944	cellular_component	cell periphery
E	0097446	biological_process	protein localization to eisosome filament
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005811	cellular_component	lipid droplet
F	0005886	cellular_component	plasma membrane
F	0006897	biological_process	endocytosis
F	0008104	biological_process	intracellular protein localization
F	0008289	molecular_function	lipid binding
F	0032126	cellular_component	eisosome
F	0036286	cellular_component	eisosome filament
F	0070941	biological_process	eisosome assembly
F	0071944	cellular_component	cell periphery
F	0097446	biological_process	protein localization to eisosome filament
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005811	cellular_component	lipid droplet
G	0005886	cellular_component	plasma membrane
G	0006897	biological_process	endocytosis
G	0008104	biological_process	intracellular protein localization
G	0008289	molecular_function	lipid binding
G	0032126	cellular_component	eisosome
G	0036286	cellular_component	eisosome filament
G	0070941	biological_process	eisosome assembly
G	0071944	cellular_component	cell periphery
G	0097446	biological_process	protein localization to eisosome filament
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005811	cellular_component	lipid droplet
H	0005886	cellular_component	plasma membrane
H	0006897	biological_process	endocytosis
H	0008104	biological_process	intracellular protein localization
H	0008289	molecular_function	lipid binding
H	0032126	cellular_component	eisosome
H	0036286	cellular_component	eisosome filament
H	0070941	biological_process	eisosome assembly
H	0071944	cellular_component	cell periphery
H	0097446	biological_process	protein localization to eisosome filament
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005811	cellular_component	lipid droplet
I	0005886	cellular_component	plasma membrane
I	0006897	biological_process	endocytosis
I	0008104	biological_process	intracellular protein localization
I	0008289	molecular_function	lipid binding
I	0032126	cellular_component	eisosome
I	0036286	cellular_component	eisosome filament
I	0070941	biological_process	eisosome assembly
I	0071944	cellular_component	cell periphery
I	0097446	biological_process	protein localization to eisosome filament
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005811	cellular_component	lipid droplet
J	0005886	cellular_component	plasma membrane
J	0006897	biological_process	endocytosis
J	0008104	biological_process	intracellular protein localization
J	0008289	molecular_function	lipid binding
J	0032126	cellular_component	eisosome
J	0036286	cellular_component	eisosome filament
J	0070941	biological_process	eisosome assembly
J	0071944	cellular_component	cell periphery
J	0097446	biological_process	protein localization to eisosome filament
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0005811	cellular_component	lipid droplet
K	0005886	cellular_component	plasma membrane
K	0006897	biological_process	endocytosis
K	0008104	biological_process	intracellular protein localization
K	0008289	molecular_function	lipid binding
K	0032126	cellular_component	eisosome
K	0036286	cellular_component	eisosome filament
K	0070941	biological_process	eisosome assembly
K	0071944	cellular_component	cell periphery
K	0097446	biological_process	protein localization to eisosome filament
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005741	cellular_component	mitochondrial outer membrane
L	0005811	cellular_component	lipid droplet
L	0005886	cellular_component	plasma membrane
L	0006897	biological_process	endocytosis
L	0008104	biological_process	intracellular protein localization
L	0008289	molecular_function	lipid binding
L	0032126	cellular_component	eisosome
L	0036286	cellular_component	eisosome filament
L	0070941	biological_process	eisosome assembly
L	0071944	cellular_component	cell periphery
L	0097446	biological_process	protein localization to eisosome filament
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005741	cellular_component	mitochondrial outer membrane
M	0005811	cellular_component	lipid droplet
M	0005886	cellular_component	plasma membrane
M	0006897	biological_process	endocytosis
M	0008104	biological_process	intracellular protein localization
M	0008289	molecular_function	lipid binding
M	0032126	cellular_component	eisosome
M	0036286	cellular_component	eisosome filament
M	0070941	biological_process	eisosome assembly
M	0071944	cellular_component	cell periphery
M	0097446	biological_process	protein localization to eisosome filament
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005741	cellular_component	mitochondrial outer membrane
N	0005811	cellular_component	lipid droplet
N	0005886	cellular_component	plasma membrane
N	0006897	biological_process	endocytosis
N	0008104	biological_process	intracellular protein localization
N	0008289	molecular_function	lipid binding
N	0032126	cellular_component	eisosome
N	0036286	cellular_component	eisosome filament
N	0070941	biological_process	eisosome assembly
N	0071944	cellular_component	cell periphery
N	0097446	biological_process	protein localization to eisosome filament

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	420
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	252
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	42
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	14
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	14
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	28
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)