8QAU

Outer kinetochore Ndc80-Dam1 alpha/beta-tubulin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000779	cellular_component	condensed chromosome, centromeric region
A	0000940	cellular_component	outer kinetochore
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0007059	biological_process	chromosome segregation
A	0008017	molecular_function	microtubule binding
A	0031262	cellular_component	Ndc80 complex
A	0034501	biological_process	protein localization to kinetochore
A	0042802	molecular_function	identical protein binding
A	0051301	biological_process	cell division
A	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
A	1990758	biological_process	mitotic sister chromatid biorientation
B	0000776	cellular_component	kinetochore
B	0000779	cellular_component	condensed chromosome, centromeric region
B	0000940	cellular_component	outer kinetochore
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005816	cellular_component	spindle pole body
B	0005876	cellular_component	spindle microtubule
B	0007052	biological_process	mitotic spindle organization
B	0007059	biological_process	chromosome segregation
B	0008017	molecular_function	microtubule binding
B	0031262	cellular_component	Ndc80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045132	biological_process	meiotic chromosome segregation
B	0051301	biological_process	cell division
B	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
B	0051383	biological_process	kinetochore organization
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0030182	biological_process	neuron differentiation
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0001764	biological_process	neuron migration
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0000776	cellular_component	kinetochore
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005819	cellular_component	spindle
E	0005874	cellular_component	microtubule
E	0007059	biological_process	chromosome segregation
E	0008017	molecular_function	microtubule binding
E	0008608	biological_process	attachment of spindle microtubules to kinetochore
E	0031116	biological_process	positive regulation of microtubule polymerization
E	0042729	cellular_component	DASH complex
E	0042802	molecular_function	identical protein binding
E	0044732	cellular_component	mitotic spindle pole body
E	0051010	molecular_function	microtubule plus-end binding
E	0051301	biological_process	cell division
E	0051987	biological_process	positive regulation of attachment of spindle microtubules to kinetochore
E	0071459	biological_process	protein localization to chromosome, centromeric region
E	0072686	cellular_component	mitotic spindle
E	0098653	biological_process	centromere clustering
E	1990537	cellular_component	mitotic spindle polar microtubule
E	1990758	biological_process	mitotic sister chromatid biorientation
E	1990976	biological_process	protein transport along microtubule to mitotic spindle pole body

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
C	GLY142-GLY148
D	GLY140-GLY146

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
D	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by IPL1","evidences":[{"source":"PubMed","id":"12408861","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by IPL1","evidences":[{"source":"PubMed","id":"12408861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---