8QA2

Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; Nconst-mon conformation

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD

Chain	Residue	Details
A	CYS53-ASP66

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site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP

Chain	Residue	Details
A	CYS169-PRO185

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	INTRAMEM: INTRAMEM => ECO:0000269|PubMed:26753910

Chain	Residue	Details
A	ASP2-VAL13
J	ASP2-VAL13
K	ASP2-VAL13
L	ASP2-VAL13
B	ASP2-VAL13
C	ASP2-VAL13
D	ASP2-VAL13
E	ASP2-VAL13
F	ASP2-VAL13
G	ASP2-VAL13
H	ASP2-VAL13
I	ASP2-VAL13

---

site_id	SWS_FT_FI2
Number of Residues	732
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26753910

Chain	Residue	Details
A	ASN14-ILE20
D	ASN14-ILE20
D	VAL95-THR135
D	CYS211-VAL226
E	ASN14-ILE20
E	VAL95-THR135
E	CYS211-VAL226
F	ASN14-ILE20
F	VAL95-THR135
F	CYS211-VAL226
G	ASN14-ILE20
A	VAL95-THR135
G	VAL95-THR135
G	CYS211-VAL226
H	ASN14-ILE20
H	VAL95-THR135
H	CYS211-VAL226
I	ASN14-ILE20
I	VAL95-THR135
I	CYS211-VAL226
J	ASN14-ILE20
J	VAL95-THR135
A	CYS211-VAL226
J	CYS211-VAL226
K	ASN14-ILE20
K	VAL95-THR135
K	CYS211-VAL226
L	ASN14-ILE20
L	VAL95-THR135
L	CYS211-VAL226
B	ASN14-ILE20
B	VAL95-THR135
B	CYS211-VAL226
C	ASN14-ILE20
C	VAL95-THR135
C	CYS211-VAL226

---

site_id	SWS_FT_FI3
Number of Residues	948
Details	TRANSMEM: Helical => ECO:0000269|PubMed:26753910

Chain	Residue	Details
A	GLY21-ALA40
C	ILE74-HIS94
C	TYR136-VAL156
C	VAL190-LEU210
D	GLY21-ALA40
D	ILE74-HIS94
D	TYR136-VAL156
D	VAL190-LEU210
E	GLY21-ALA40
E	ILE74-HIS94
E	TYR136-VAL156
A	ILE74-HIS94
E	VAL190-LEU210
F	GLY21-ALA40
F	ILE74-HIS94
F	TYR136-VAL156
F	VAL190-LEU210
G	GLY21-ALA40
G	ILE74-HIS94
G	TYR136-VAL156
G	VAL190-LEU210
H	GLY21-ALA40
A	TYR136-VAL156
H	ILE74-HIS94
H	TYR136-VAL156
H	VAL190-LEU210
I	GLY21-ALA40
I	ILE74-HIS94
I	TYR136-VAL156
I	VAL190-LEU210
J	GLY21-ALA40
J	ILE74-HIS94
J	TYR136-VAL156
A	VAL190-LEU210
J	VAL190-LEU210
K	GLY21-ALA40
K	ILE74-HIS94
K	TYR136-VAL156
K	VAL190-LEU210
L	GLY21-ALA40
L	ILE74-HIS94
L	TYR136-VAL156
L	VAL190-LEU210
B	GLY21-ALA40
B	ILE74-HIS94
B	TYR136-VAL156
B	VAL190-LEU210
C	GLY21-ALA40

---

site_id	SWS_FT_FI4
Number of Residues	768
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26753910

Chain	Residue	Details
A	LYS41-HIS73
E	MET157-THR189
F	LYS41-HIS73
F	MET157-THR189
G	LYS41-HIS73
G	MET157-THR189
H	LYS41-HIS73
H	MET157-THR189
I	LYS41-HIS73
I	MET157-THR189
J	LYS41-HIS73
A	MET157-THR189
J	MET157-THR189
K	LYS41-HIS73
K	MET157-THR189
L	LYS41-HIS73
L	MET157-THR189
B	LYS41-HIS73
B	MET157-THR189
C	LYS41-HIS73
C	MET157-THR189
D	LYS41-HIS73
D	MET157-THR189
E	LYS41-HIS73

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: in other chain => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7

Chain	Residue	Details
A	GLU42
J	GLU42
K	GLU42
L	GLU42
B	GLU42
C	GLU42
D	GLU42
E	GLU42
F	GLU42
G	GLU42
H	GLU42
I	GLU42

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7

Chain	Residue	Details
A	GLY45
E	GLU47
F	GLY45
F	GLU47
G	GLY45
G	GLU47
H	GLY45
H	GLU47
I	GLY45
I	GLU47
J	GLY45
A	GLU47
J	GLU47
K	GLY45
K	GLU47
L	GLY45
L	GLU47
B	GLY45
B	GLU47
C	GLY45
C	GLU47
D	GLY45
D	GLU47
E	GLY45

---