8QA0

Cryo-EM structure of Cx26 solubilised in LMNG - hemichannel classification - NConst conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007267	biological_process	cell-cell signaling
A	0007605	biological_process	sensory perception of sound
A	0010644	biological_process	cell communication by electrical coupling
A	0016264	biological_process	gap junction assembly
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
A	1990349	biological_process	gap junction-mediated intercellular transport
B	0005243	molecular_function	gap junction channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007267	biological_process	cell-cell signaling
B	0007605	biological_process	sensory perception of sound
B	0010644	biological_process	cell communication by electrical coupling
B	0016264	biological_process	gap junction assembly
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
B	1990349	biological_process	gap junction-mediated intercellular transport
C	0005243	molecular_function	gap junction channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
C	0007267	biological_process	cell-cell signaling
C	0007605	biological_process	sensory perception of sound
C	0010644	biological_process	cell communication by electrical coupling
C	0016264	biological_process	gap junction assembly
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
C	1990349	biological_process	gap junction-mediated intercellular transport
D	0005243	molecular_function	gap junction channel activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
D	0007267	biological_process	cell-cell signaling
D	0007605	biological_process	sensory perception of sound
D	0010644	biological_process	cell communication by electrical coupling
D	0016264	biological_process	gap junction assembly
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
D	1990349	biological_process	gap junction-mediated intercellular transport
E	0005243	molecular_function	gap junction channel activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
E	0007267	biological_process	cell-cell signaling
E	0007605	biological_process	sensory perception of sound
E	0010644	biological_process	cell communication by electrical coupling
E	0016264	biological_process	gap junction assembly
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0055085	biological_process	transmembrane transport
E	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
E	1990349	biological_process	gap junction-mediated intercellular transport
F	0005243	molecular_function	gap junction channel activity
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication
F	0007267	biological_process	cell-cell signaling
F	0007605	biological_process	sensory perception of sound
F	0010644	biological_process	cell communication by electrical coupling
F	0016264	biological_process	gap junction assembly
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0055085	biological_process	transmembrane transport
F	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
F	1990349	biological_process	gap junction-mediated intercellular transport
G	0005243	molecular_function	gap junction channel activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
G	0005886	cellular_component	plasma membrane
G	0005921	cellular_component	gap junction
G	0005922	cellular_component	connexin complex
G	0007154	biological_process	cell communication
G	0007267	biological_process	cell-cell signaling
G	0007605	biological_process	sensory perception of sound
G	0010644	biological_process	cell communication by electrical coupling
G	0016264	biological_process	gap junction assembly
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0055085	biological_process	transmembrane transport
G	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
G	1990349	biological_process	gap junction-mediated intercellular transport
H	0005243	molecular_function	gap junction channel activity
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
H	0005886	cellular_component	plasma membrane
H	0005921	cellular_component	gap junction
H	0005922	cellular_component	connexin complex
H	0007154	biological_process	cell communication
H	0007267	biological_process	cell-cell signaling
H	0007605	biological_process	sensory perception of sound
H	0010644	biological_process	cell communication by electrical coupling
H	0016264	biological_process	gap junction assembly
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0055085	biological_process	transmembrane transport
H	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
H	1990349	biological_process	gap junction-mediated intercellular transport
I	0005243	molecular_function	gap junction channel activity
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
I	0005886	cellular_component	plasma membrane
I	0005921	cellular_component	gap junction
I	0005922	cellular_component	connexin complex
I	0007154	biological_process	cell communication
I	0007267	biological_process	cell-cell signaling
I	0007605	biological_process	sensory perception of sound
I	0010644	biological_process	cell communication by electrical coupling
I	0016264	biological_process	gap junction assembly
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0055085	biological_process	transmembrane transport
I	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
I	1990349	biological_process	gap junction-mediated intercellular transport
J	0005243	molecular_function	gap junction channel activity
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
J	0005886	cellular_component	plasma membrane
J	0005921	cellular_component	gap junction
J	0005922	cellular_component	connexin complex
J	0007154	biological_process	cell communication
J	0007267	biological_process	cell-cell signaling
J	0007605	biological_process	sensory perception of sound
J	0010644	biological_process	cell communication by electrical coupling
J	0016264	biological_process	gap junction assembly
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0055085	biological_process	transmembrane transport
J	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
J	1990349	biological_process	gap junction-mediated intercellular transport
K	0005243	molecular_function	gap junction channel activity
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
K	0005886	cellular_component	plasma membrane
K	0005921	cellular_component	gap junction
K	0005922	cellular_component	connexin complex
K	0007154	biological_process	cell communication
K	0007267	biological_process	cell-cell signaling
K	0007605	biological_process	sensory perception of sound
K	0010644	biological_process	cell communication by electrical coupling
K	0016264	biological_process	gap junction assembly
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
K	0055085	biological_process	transmembrane transport
K	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
K	1990349	biological_process	gap junction-mediated intercellular transport
L	0005243	molecular_function	gap junction channel activity
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
L	0005886	cellular_component	plasma membrane
L	0005921	cellular_component	gap junction
L	0005922	cellular_component	connexin complex
L	0007154	biological_process	cell communication
L	0007267	biological_process	cell-cell signaling
L	0007605	biological_process	sensory perception of sound
L	0010644	biological_process	cell communication by electrical coupling
L	0016264	biological_process	gap junction assembly
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding
L	0055085	biological_process	transmembrane transport
L	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
L	1990349	biological_process	gap junction-mediated intercellular transport

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD

Chain	Residue	Details
A	CYS53-ASP66

---

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP

Chain	Residue	Details
A	CYS169-PRO185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	948
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	768
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ER7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ER7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---