8Q8E

Tau - AD-LIA4 (tau intermediate amyloid)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008017	molecular_function	microtubule binding
A	0015631	molecular_function	tubulin binding
B	0008017	molecular_function	microtubule binding
B	0015631	molecular_function	tubulin binding
C	0008017	molecular_function	microtubule binding
C	0015631	molecular_function	tubulin binding
D	0008017	molecular_function	microtubule binding
D	0015631	molecular_function	tubulin binding
E	0008017	molecular_function	microtubule binding
E	0015631	molecular_function	tubulin binding
F	0008017	molecular_function	microtubule binding
F	0015631	molecular_function	tubulin binding
G	0008017	molecular_function	microtubule binding
G	0015631	molecular_function	tubulin binding
H	0008017	molecular_function	microtubule binding
H	0015631	molecular_function	tubulin binding
I	0008017	molecular_function	microtubule binding
I	0015631	molecular_function	tubulin binding
J	0008017	molecular_function	microtubule binding
J	0015631	molecular_function	tubulin binding
K	0008017	molecular_function	microtubule binding
K	0015631	molecular_function	tubulin binding
L	0008017	molecular_function	microtubule binding
L	0015631	molecular_function	tubulin binding

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG

Chain	Residue	Details
A	GLY261-GLY273
A	GLY292-GLY304
A	GLY323-GLY335
A	GLY355-GLY367

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	336
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS83
A	LYS103
A	ARG126
A	GLY440
A	LYS148
A	LYS180
A	LYS254
A	LYS257
A	LYS274
A	LYS290
A	LYS294
A	LYS311
A	LYS317
A	LYS321
A	LYS331
A	LYS340
A	LYS343
A	LYS370
A	LYS383
A	LYS385
A	LYS395
A	LYS438
C	LYS83
C	LYS267
C	LYS274
C	LYS298
C	LYS311
C	LYS340
C	LYS343
C	LYS370
C	LYS375
C	LYS383
C	LYS385
C	LYS395
C	LYS438
E	LYS83
E	LYS103
E	ARG126
E	GLY440
E	LYS148
E	LYS180
E	LYS190
E	LYS224
E	LYS240
E	LYS254
E	LYS257
E	LYS267
E	LYS274
E	LYS290
E	LYS294
E	LYS298
E	LYS311
E	LYS317
E	LYS321
E	LYS331
E	LYS340
E	LYS343
E	LYS370
E	LYS375
E	LYS383
E	LYS385
E	LYS395
E	LYS438
B	LYS83
B	LYS103
B	ARG126
B	GLY440
B	LYS148
B	LYS180
B	LYS190
B	LYS224
B	LYS240
B	LYS254
B	LYS257
B	LYS267
B	LYS274
B	LYS290
B	LYS294
B	LYS298
B	LYS311
B	LYS317
B	LYS321
B	LYS331
B	LYS340
B	LYS343
B	LYS370
B	LYS375
B	LYS383
B	LYS385
B	LYS395
B	LYS438
D	LYS83
D	LYS103
D	ARG126
D	GLY440
D	LYS148
D	LYS180
D	LYS190
D	LYS224
D	LYS240
D	LYS254
D	LYS257
D	LYS267
D	LYS274
D	LYS290
D	LYS294
D	LYS298
D	LYS311
D	LYS317
D	LYS321
D	LYS331
D	LYS340
D	LYS343
D	LYS370
D	LYS375
D	LYS383
D	LYS385
D	LYS395
D	LYS438
F	LYS83
F	LYS103
F	ARG126
F	GLY440
F	LYS148
F	LYS180
F	LYS190
F	LYS224
F	LYS240
F	LYS254
F	LYS257
F	LYS267
F	LYS274
F	LYS290
F	LYS294
F	LYS298
F	LYS311
F	LYS317
F	LYS321
F	LYS331
F	LYS340
F	LYS343
F	LYS370
F	LYS375
F	LYS383
F	LYS385
F	LYS395
F	LYS438
G	LYS83
G	LYS103
G	ARG126
G	GLY440
G	LYS148
G	LYS180
G	LYS190
G	LYS224
G	LYS240
G	LYS254
G	LYS257
G	LYS267
G	LYS274
G	LYS290
G	LYS294
G	LYS298
G	LYS311
G	LYS317
G	LYS321
G	LYS331
G	LYS340
G	LYS343
G	LYS370
G	LYS375
G	LYS383
G	LYS385
G	LYS395
G	LYS438
H	LYS83
H	LYS103
H	ARG126
H	GLY440
H	LYS148
H	LYS180
H	LYS190
H	LYS224
H	LYS240
H	LYS254
H	LYS257
H	LYS267
H	LYS274
H	LYS290
H	LYS294
H	LYS298
H	LYS311
H	LYS317
H	LYS321
H	LYS331
H	LYS340
H	LYS343
H	LYS370
H	LYS375
H	LYS383
H	LYS385
H	LYS395
H	LYS438
I	LYS83
I	LYS103
I	ARG126
I	GLY440
I	LYS148
I	LYS180
I	LYS190
I	LYS224
I	LYS240
I	LYS254
I	LYS257
I	LYS267
I	LYS274
I	LYS290
I	LYS294
I	LYS298
I	LYS311
I	LYS317
I	LYS321
I	LYS331
I	LYS340
I	LYS343
I	LYS370
I	LYS375
I	LYS383
I	LYS385
I	LYS395
I	LYS438
J	LYS83
J	LYS103
J	ARG126
J	GLY440
J	LYS148
J	LYS180
J	LYS190
J	LYS224
J	LYS240
J	LYS254
J	LYS257
J	LYS267
J	LYS274
J	LYS290
J	LYS294
J	LYS298
J	LYS311
J	LYS317
J	LYS321
J	LYS331
J	LYS340
J	LYS343
J	LYS370
J	LYS375
J	LYS383
J	LYS385
J	LYS395
J	LYS438
K	LYS83
K	LYS103
K	ARG126
K	GLY440
K	LYS148
K	LYS180
K	LYS190
K	LYS224
K	LYS240
K	LYS254
K	LYS257
K	LYS267
K	LYS274
K	LYS290
K	LYS294
K	LYS298
K	LYS311
K	LYS317
K	LYS321
K	LYS331
K	LYS340
K	LYS343
K	LYS370
K	LYS375
K	LYS383
K	LYS385
K	LYS395
K	LYS438
L	LYS83
L	LYS103
L	ARG126
L	GLY440
L	LYS148
L	LYS180
L	LYS190
L	LYS224
L	LYS240
L	LYS254
L	LYS257
L	LYS267
L	LYS274
L	LYS290
L	LYS294
L	LYS298
L	LYS311
L	LYS317
L	LYS321
L	LYS331
L	LYS340
L	LYS343
L	LYS370
L	LYS375
L	LYS383
L	LYS385
L	LYS395
L	LYS438
A	LYS190
A	LYS224
A	LYS240
A	LYS267
A	LYS298
A	LYS375
C	LYS103
C	ARG126
C	GLY440
C	LYS148
C	LYS180
C	LYS190
C	LYS224
C	LYS240
C	LYS254
C	LYS257
C	LYS290
C	LYS294
C	LYS317
C	LYS321
C	LYS331

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244

Chain	Residue	Details
A	ALA61
C	ALA61
E	ALA61
B	ALA61
D	ALA61
F	ALA61
G	ALA61
H	ALA61
I	ALA61
J	ALA61
K	ALA61
L	ALA61

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081

Chain	Residue	Details
A	TYR77
C	TYR77
E	TYR77
B	TYR77
D	TYR77
F	TYR77
G	TYR77
H	TYR77
I	TYR77
J	TYR77
K	TYR77
L	TYR77

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	TYR88
C	TYR88
E	TYR88
B	TYR88
F	TYR394
G	TYR88
G	TYR394
H	TYR88
H	TYR394
I	TYR88
I	TYR394
J	TYR88
J	TYR394
K	TYR88
K	TYR394
L	TYR88
L	TYR394
A	TYR394
C	TYR394
E	TYR394
B	TYR394
D	TYR88
D	TYR394
F	TYR88

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332

Chain	Residue	Details
A	GLU105
A	GLY120
C	GLU105
C	GLY120
E	GLU105
E	GLY120
B	GLU105
B	GLY120
D	GLU105
D	GLY120
F	GLU105
F	GLY120
G	GLU105
G	GLY120
H	GLU105
H	GLY120
I	GLU105
I	GLY120
J	GLU105
J	GLY120
K	GLU105
K	GLY120
L	GLU105
L	GLY120

---

site_id	SWS_FT_FI6
Number of Residues	60
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	VAL128
A	ARG170
A	THR175
C	ARG170
C	THR169
C	THR175
C	THR403
E	VAL128
E	ARG170
E	THR169
E	THR403
B	VAL128
B	THR169
B	THR175
D	THR169
D	THR403
F	VAL128
F	ARG170
F	THR169
F	THR175
F	THR403
G	VAL128
G	ARG170
G	THR169
G	THR175
G	THR403
H	VAL128
H	ARG170
H	THR169
H	THR175
H	THR403
I	VAL128
I	ARG170
I	THR169
I	THR175
I	THR403
J	VAL128
J	ARG170
J	THR169
J	THR175
J	THR403
K	VAL128
K	ARG170
K	THR169
K	THR175
K	THR403
L	VAL128
L	ARG170
L	THR169
L	THR175
L	THR403
A	THR169
A	THR403
C	VAL128
E	THR175
B	ARG170
B	THR403
D	VAL128
D	ARG170
D	THR175

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332

Chain	Residue	Details
A	LYS130
C	LYS130
E	LYS130
B	LYS130
D	LYS130
F	LYS130
G	LYS130
H	LYS130
I	LYS130
J	LYS130
K	LYS130
L	LYS130

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696

Chain	Residue	Details
A	GLY273
C	GLY273
E	GLY273
B	GLY273
D	GLY273
F	GLY273
G	GLY273
H	GLY273
I	GLY273
J	GLY273
K	GLY273
L	GLY273

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:9614189

Chain	Residue	Details
G	THR153
C	THR153
B	THR153
F	THR153
H	THR153
J	THR153
L	THR153
A	THR153
E	THR153
D	THR153
I	THR153
K	THR153

---

site_id	SWS_FT_FI10
Number of Residues	24
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
B	ARG155
J	ARG155
L	ARG155
A	ARG349
C	ARG349
E	ARG349
B	ARG349
D	ARG349
F	ARG349
G	ARG349
H	ARG349
I	ARG349
J	ARG349
K	ARG349
L	ARG349
A	ARG155
C	ARG155
E	ARG155
D	ARG155
F	ARG155
G	ARG155
H	ARG155
I	ARG155
K	ARG155

---

site_id	SWS_FT_FI11
Number of Residues	132
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS163
A	LYS281
A	LYS298
A	LYS311
A	LYS317
A	LYS321
A	LYS331
A	LYS343
A	LYS347
A	LYS369
A	LYS385
C	LYS163
C	LYS281
C	LYS298
C	LYS311
C	LYS317
C	LYS321
C	LYS331
C	LYS343
C	LYS347
C	LYS369
C	LYS385
E	LYS163
E	LYS281
E	LYS298
E	LYS311
E	LYS317
E	LYS321
E	LYS331
E	LYS343
E	LYS347
E	LYS369
E	LYS385
B	LYS163
B	LYS281
B	LYS298
B	LYS311
B	LYS317
B	LYS321
B	LYS331
B	LYS343
B	LYS347
B	LYS369
B	LYS385
D	LYS163
D	LYS281
D	LYS298
D	LYS311
D	LYS317
D	LYS321
D	LYS331
D	LYS343
D	LYS347
D	LYS369
D	LYS385
F	LYS163
F	LYS281
F	LYS298
F	LYS311
F	LYS317
F	LYS321
F	LYS331
F	LYS343
F	LYS347
F	LYS369
F	LYS385
G	LYS163
G	LYS281
G	LYS298
G	LYS311
G	LYS317
G	LYS321
G	LYS331
G	LYS343
G	LYS347
G	LYS369
G	LYS385
H	LYS163
H	LYS281
H	LYS298
H	LYS311
H	LYS317
H	LYS321
H	LYS331
H	LYS343
H	LYS347
H	LYS369
H	LYS385
I	LYS163
I	LYS281
I	LYS298
I	LYS311
I	LYS317
I	LYS321
I	LYS331
I	LYS343
I	LYS347
I	LYS369
I	LYS385
J	LYS163
J	LYS281
J	LYS298
J	LYS311
J	LYS317
J	LYS321
J	LYS331
J	LYS343
J	LYS347
J	LYS369
J	LYS385
K	LYS163
K	LYS281
K	LYS298
K	LYS311
K	LYS317
K	LYS321
K	LYS331
K	LYS343
K	LYS347
K	LYS369
K	LYS385
L	LYS163
L	LYS281
L	LYS298
L	LYS311
L	LYS317
L	LYS321
L	LYS331
L	LYS343
L	LYS347
L	LYS369
L	LYS385

---

site_id	SWS_FT_FI12
Number of Residues	24
Details	MOD_RES: Deamidated asparagine; in tau and PHF-tau; partial => ECO:0000269|PubMed:1512244

Chain	Residue	Details
A	ASN167
A	ASN279
C	ASN167
C	ASN279
E	ASN167
E	ASN279
B	ASN167
B	ASN279
D	ASN167
D	ASN279
F	ASN167
F	ASN279
G	ASN167
G	ASN279
H	ASN167
H	ASN279
I	ASN167
I	ASN279
J	ASN167
J	ASN279
K	ASN167
K	ASN279
L	ASN167
L	ASN279

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:15546861

Chain	Residue	Details
A	THR181
C	THR181
E	THR181
B	THR181
D	THR181
F	THR181
G	THR181
H	THR181
I	THR181
J	THR181
K	THR181
L	THR181

---

site_id	SWS_FT_FI14
Number of Residues	36
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	SER185
A	SER191
A	SER195
C	SER185
C	SER191
C	SER195
E	SER185
E	SER191
E	SER195
B	SER185
B	SER191
B	SER195
D	SER185
D	SER191
D	SER195
F	SER185
F	SER191
F	SER195
G	SER185
G	SER191
G	SER195
H	SER185
H	SER191
H	SER195
I	SER185
I	SER191
I	SER195
J	SER185
J	SER191
J	SER195
K	SER185
K	SER191
K	SER195
L	SER185
L	SER191
L	SER195

---

site_id	SWS_FT_FI15
Number of Residues	12
Details	MOD_RES: Phosphotyrosine; by TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	TYR197
C	TYR197
E	TYR197
B	TYR197
D	TYR197
F	TYR197
G	TYR197
H	TYR197
I	TYR197
J	TYR197
K	TYR197
L	TYR197

---

site_id	SWS_FT_FI16
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	SER198
C	SER198
E	SER198
B	SER198
D	SER198
F	SER198
G	SER198
H	SER198
I	SER198
J	SER198
K	SER198
L	SER198

---

site_id	SWS_FT_FI17
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER199
C	SER199
E	SER199
B	SER199
D	SER199
F	SER199
G	SER199
H	SER199
I	SER199
J	SER199
K	SER199
L	SER199

---

site_id	SWS_FT_FI18
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CK1, PDPK1 and TTBK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER202
C	SER202
E	SER202
B	SER202
D	SER202
F	SER202
G	SER202
H	SER202
I	SER202
J	SER202
K	SER202
L	SER202

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179

Chain	Residue	Details
A	THR205
C	THR205
E	THR205
B	THR205
D	THR205
F	THR205
G	THR205
H	THR205
I	THR205
J	THR205
K	THR205
L	THR205

---

site_id	SWS_FT_FI20
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	THR212
C	THR212
E	THR212
B	THR212
D	THR212
F	THR212
G	THR212
H	THR212
I	THR212
J	THR212
K	THR212
L	THR212

---

site_id	SWS_FT_FI21
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER214
C	SER214
E	SER214
B	SER214
D	SER214
F	SER214
G	SER214
H	SER214
I	SER214
J	SER214
K	SER214
L	SER214

---

site_id	SWS_FT_FI22
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179

Chain	Residue	Details
A	THR217
C	THR217
E	THR217
B	THR217
D	THR217
F	THR217
G	THR217
H	THR217
I	THR217
J	THR217
K	THR217
L	THR217

---

site_id	SWS_FT_FI23
Number of Residues	24
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS225
A	LYS290
C	LYS225
C	LYS290
E	LYS225
E	LYS290
B	LYS225
B	LYS290
D	LYS225
D	LYS290
F	LYS225
F	LYS290
G	LYS225
G	LYS290
H	LYS225
H	LYS290
I	LYS225
I	LYS290
J	LYS225
J	LYS290
K	LYS225
K	LYS290
L	LYS225
L	LYS290

---

site_id	SWS_FT_FI24
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR231
C	THR231
E	THR231
B	THR231
D	THR231
F	THR231
G	THR231
H	THR231
I	THR231
J	THR231
K	THR231
L	THR231

---

site_id	SWS_FT_FI25
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER235
C	SER235
E	SER235
B	SER235
D	SER235
F	SER235
G	SER235
H	SER235
I	SER235
J	SER235
K	SER235
L	SER235

---

site_id	SWS_FT_FI26
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860

Chain	Residue	Details
A	SER237
C	SER237
E	SER237
B	SER237
D	SER237
F	SER237
G	SER237
H	SER237
I	SER237
J	SER237
K	SER237
L	SER237

---

site_id	SWS_FT_FI27
Number of Residues	12
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS259
C	LYS259
E	LYS259
B	LYS259
D	LYS259
F	LYS259
G	LYS259
H	LYS259
I	LYS259
J	LYS259
K	LYS259
L	LYS259

---

site_id	SWS_FT_FI28
Number of Residues	12
Details	MOD_RES: Phosphoserine; by MARK1, MARK2, MARK3, MARK4, BRSK1, BRSK2 and PHK => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER262
C	SER262
E	SER262
B	SER262
D	SER262
F	SER262
G	SER262
H	SER262
I	SER262
J	SER262
K	SER262
L	SER262

---

site_id	SWS_FT_FI29
Number of Residues	24
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:8999860

Chain	Residue	Details
A	SER285
A	SER352
C	SER285
C	SER352
E	SER285
E	SER352
B	SER285
B	SER352
D	SER285
D	SER352
F	SER285
F	SER352
G	SER285
G	SER352
H	SER285
H	SER352
I	SER285
I	SER352
J	SER285
J	SER352
K	SER285
K	SER352
L	SER285
L	SER352

---

site_id	SWS_FT_FI30
Number of Residues	36
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316

Chain	Residue	Details
A	SER293
A	SER324
A	SER356
C	SER293
C	SER324
C	SER356
E	SER293
E	SER324
E	SER356
B	SER293
B	SER324
B	SER356
D	SER293
D	SER324
D	SER356
F	SER293
F	SER324
F	SER356
G	SER293
G	SER324
G	SER356
H	SER293
H	SER324
H	SER356
I	SER293
I	SER324
I	SER356
J	SER293
J	SER324
J	SER356
K	SER293
K	SER324
K	SER356
L	SER293
L	SER324
L	SER356

---

site_id	SWS_FT_FI31
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860

Chain	Residue	Details
A	SER305
C	SER305
E	SER305
B	SER305
D	SER305
F	SER305
G	SER305
H	SER305
I	SER305
J	SER305
K	SER305
L	SER305

---

site_id	SWS_FT_FI32
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER396
C	SER396
E	SER396
B	SER396
D	SER396
F	SER396
G	SER396
H	SER396
I	SER396
J	SER396
K	SER396
L	SER396

---

site_id	SWS_FT_FI33
Number of Residues	12
Details	MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER400
C	SER400
E	SER400
B	SER400
D	SER400
F	SER400
G	SER400
H	SER400
I	SER400
J	SER400
K	SER400
L	SER400

---

site_id	SWS_FT_FI34
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER404
C	SER404
E	SER404
B	SER404
D	SER404
F	SER404
G	SER404
H	SER404
I	SER404
J	SER404
K	SER404
L	SER404

---

site_id	SWS_FT_FI35
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15546861, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER409
C	SER409
E	SER409
B	SER409
D	SER409
F	SER409
G	SER409
H	SER409
I	SER409
J	SER409
K	SER409
L	SER409

---

site_id	SWS_FT_FI36
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CaMK2 and TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	SER416
C	SER416
E	SER416
B	SER416
D	SER416
F	SER416
G	SER416
H	SER416
I	SER416
J	SER416
K	SER416
L	SER416

---

site_id	SWS_FT_FI37
Number of Residues	12
Details	MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER422
C	SER422
E	SER422
B	SER422
D	SER422
F	SER422
G	SER422
H	SER422
I	SER422
J	SER422
K	SER422
L	SER422

---

site_id	SWS_FT_FI38
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	THR427
C	THR427
E	THR427
B	THR427
D	THR427
F	THR427
G	THR427
H	THR427
I	THR427
J	THR427
K	THR427
L	THR427

---

site_id	SWS_FT_FI39
Number of Residues	156
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	ASP146
A	LYS150
A	LYS163
A	LYS174
A	LYS225
A	LYS234
A	LYS259
A	LYS280
A	LYS281
A	LYS347
A	LYS353
A	LYS369
C	ASP146
C	LYS150
C	LYS163
C	LYS174
C	LYS225
C	LYS234
C	LYS259
C	LYS280
C	LYS281
C	LYS347
C	LYS353
C	LYS369
E	ASP146
E	LYS150
E	LYS163
E	LYS174
E	LYS225
E	LYS234
E	LYS259
E	LYS280
E	LYS281
E	LYS347
E	LYS353
E	LYS369
B	ASP146
B	LYS150
B	LYS163
B	LYS174
B	LYS225
B	LYS234
B	LYS259
B	LYS280
B	LYS281
B	LYS347
B	LYS353
B	LYS369
D	ASP146
D	LYS150
D	LYS163
D	LYS174
D	LYS225
D	LYS234
D	LYS259
D	LYS280
D	LYS281
D	LYS347
D	LYS353
D	LYS369
F	ASP146
F	LYS150
F	LYS163
F	LYS174
F	LYS225
F	LYS234
F	LYS259
F	LYS280
F	LYS281
F	LYS347
F	LYS353
F	LYS369
G	ASP146
G	LYS150
G	LYS163
G	LYS174
G	LYS225
G	LYS234
G	LYS259
G	LYS280
G	LYS281
G	LYS347
G	LYS353
G	LYS369
H	ASP146
H	LYS150
H	LYS163
H	LYS174
H	LYS225
H	LYS234
H	LYS259
H	LYS280
H	LYS281
H	LYS347
H	LYS353
H	LYS369
I	ASP146
I	LYS150
I	LYS163
I	LYS174
I	LYS225
I	LYS234
I	LYS259
I	LYS280
I	LYS281
I	LYS347
I	LYS353
I	LYS369
J	ASP146
J	LYS150
J	LYS163
J	LYS174
J	LYS225
J	LYS234
J	LYS259
J	LYS280
J	LYS281
J	LYS347
J	LYS353
J	LYS369
K	ASP146
K	LYS150
K	LYS163
K	LYS174
K	LYS225
K	LYS234
K	LYS259
K	LYS280
K	LYS281
K	LYS347
K	LYS353
K	LYS369
L	ASP146
L	LYS150
L	LYS163
L	LYS174
L	LYS225
L	LYS234
L	LYS259
L	LYS280
L	LYS281
L	LYS347
L	LYS353
L	LYS369

---

site_id	SWS_FT_FI40
Number of Residues	24
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254

Chain	Residue	Details
A	SER208
A	SER238
C	SER208
C	SER238
E	SER208
E	SER238
B	SER208
B	SER238
D	SER208
D	SER238
F	SER208
F	SER238
G	SER208
G	SER238
H	SER208
H	SER238
I	SER208
I	SER238
J	SER208
J	SER238
K	SER208
K	SER238
L	SER208
L	SER238

---

site_id	SWS_FT_FI41
Number of Residues	12
Details	CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254

Chain	Residue	Details
A	SER400
C	SER400
E	SER400
B	SER400
D	SER400
F	SER400
G	SER400
H	SER400
I	SER400
J	SER400
K	SER400
L	SER400

---

site_id	SWS_FT_FI42
Number of Residues	36
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS103
A	LYS267
A	LYS375
C	LYS103
C	LYS267
C	LYS375
E	LYS103
E	LYS267
E	LYS375
B	LYS103
B	LYS267
B	LYS375
D	LYS103
D	LYS267
D	LYS375
F	LYS103
F	LYS267
F	LYS375
G	LYS103
G	LYS267
G	LYS375
H	LYS103
H	LYS267
H	LYS375
I	LYS103
I	LYS267
I	LYS375
J	LYS103
J	LYS267
J	LYS375
K	LYS103
K	LYS267
K	LYS375
L	LYS103
L	LYS267
L	LYS375

---

site_id	SWS_FT_FI43
Number of Residues	132
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS259
A	LYS281
A	LYS298
A	LYS317
A	LYS321
A	LYS331
A	LYS343
A	LYS347
A	LYS369
A	LYS385
C	LYS259
C	LYS281
C	LYS298
C	LYS317
C	LYS321
C	LYS331
C	LYS343
C	LYS347
C	LYS369
C	LYS385
E	LYS259
E	LYS281
E	LYS298
E	LYS317
E	LYS321
E	LYS331
E	LYS343
E	LYS347
E	LYS369
E	LYS385
B	LYS259
B	LYS281
B	LYS298
B	LYS317
B	LYS321
B	LYS331
B	LYS343
B	LYS347
B	LYS369
B	LYS385
D	LYS259
D	LYS281
D	LYS298
D	LYS317
D	LYS321
D	LYS331
D	LYS343
D	LYS347
D	LYS369
D	LYS385
F	LYS259
F	LYS281
F	LYS298
F	LYS317
F	LYS321
F	LYS331
F	LYS343
F	LYS347
F	LYS369
F	LYS385
G	LYS259
G	LYS281
G	LYS298
G	LYS317
G	LYS321
G	LYS331
G	LYS343
G	LYS347
G	LYS369
G	LYS385
H	LYS259
H	LYS281
H	LYS298
H	LYS317
H	LYS321
H	LYS331
H	LYS343
H	LYS347
H	LYS369
H	LYS385
I	LYS259
I	LYS281
I	LYS298
I	LYS317
I	LYS321
I	LYS331
I	LYS343
I	LYS347
I	LYS369
I	LYS385
J	LYS259
J	LYS281
J	LYS298
J	LYS317
J	LYS321
J	LYS331
J	LYS343
J	LYS347
J	LYS369
J	LYS385
K	LYS259
K	LYS281
K	LYS298
K	LYS317
K	LYS321
K	LYS331
K	LYS343
K	LYS347
K	LYS369
K	LYS385
L	LYS259
L	LYS281
L	LYS298
L	LYS317
L	LYS321
L	LYS331
L	LYS343
L	LYS347
L	LYS369
L	LYS385

---

site_id	SWS_FT_FI44
Number of Residues	36
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS254
A	LYS311
A	LYS353
C	LYS254
C	LYS311
C	LYS353
E	LYS254
E	LYS311
E	LYS353
B	LYS254
B	LYS311
B	LYS353
D	LYS254
D	LYS311
D	LYS353
F	LYS254
F	LYS311
F	LYS353
G	LYS254
G	LYS311
G	LYS353
H	LYS254
H	LYS311
H	LYS353
I	LYS254
I	LYS311
I	LYS353
J	LYS254
J	LYS311
J	LYS353
K	LYS254
K	LYS311
K	LYS353
L	LYS254
L	LYS311
L	LYS353

---