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8Q7X

Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000244biological_processspliceosomal tri-snRNP complex assembly
A0000375biological_processRNA splicing, via transesterification reactions
A0000398biological_processmRNA splicing, via spliceosome
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005682cellular_componentU5 snRNP
A0006397biological_processmRNA processing
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008380biological_processRNA splicing
A0016020cellular_componentmembrane
A0016607cellular_componentnuclear speck
A0017070molecular_functionU6 snRNA binding
A0030532cellular_componentsmall nuclear ribonucleoprotein complex
A0030619molecular_functionU1 snRNA binding
A0030620molecular_functionU2 snRNA binding
A0030623molecular_functionU5 snRNA binding
A0046540cellular_componentU4/U6 x U5 tri-snRNP complex
A0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
A0071005cellular_componentU2-type precatalytic spliceosome
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071007cellular_componentU2-type catalytic step 2 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0071222biological_processcellular response to lipopolysaccharide
A0071356biological_processcellular response to tumor necrosis factor
A0097157molecular_functionpre-mRNA intronic binding
A0140492molecular_functionmetal-dependent deubiquitinase activity
B0000354biological_processcis assembly of pre-catalytic spliceosome
B0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B0000398biological_processmRNA splicing, via spliceosome
B0001649biological_processosteoblast differentiation
B0003676molecular_functionnucleic acid binding
B0003689molecular_functionDNA clamp loader activity
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005682cellular_componentU5 snRNP
B0006338biological_processchromatin remodeling
B0006397biological_processmRNA processing
B0008380biological_processRNA splicing
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0042802molecular_functionidentical protein binding
B0046540cellular_componentU4/U6 x U5 tri-snRNP complex
B0061775molecular_functioncohesin loader activity
B0071005cellular_componentU2-type precatalytic spliceosome
B0071006cellular_componentU2-type catalytic step 1 spliceosome
B0071013cellular_componentcatalytic step 2 spliceosome
B0140584molecular_functionchromatin extrusion motor activity
B0140588biological_processchromatin looping
B0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
B0140849molecular_functionATP-dependent H2AZ histone chaperone activity
C0000398biological_processmRNA splicing, via spliceosome
C0003723molecular_functionRNA binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0005829cellular_componentcytosol
C0006397biological_processmRNA processing
C0008380biological_processRNA splicing
C0015030cellular_componentCajal body
C0016020cellular_componentmembrane
C0016607cellular_componentnuclear speck
C0030623molecular_functionU5 snRNA binding
C0042220biological_processresponse to cocaine
C0043231cellular_componentintracellular membrane-bounded organelle
C0046540cellular_componentU4/U6 x U5 tri-snRNP complex
C0071005cellular_componentU2-type precatalytic spliceosome
C0071007cellular_componentU2-type catalytic step 2 spliceosome
C0071013cellular_componentcatalytic step 2 spliceosome
C0071466biological_processcellular response to xenobiotic stimulus
D0000375biological_processRNA splicing, via transesterification reactions
D0000398biological_processmRNA splicing, via spliceosome
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005681cellular_componentspliceosomal complex
D0005682cellular_componentU5 snRNP
D0005732cellular_componentsno(s)RNA-containing ribonucleoprotein complex
D0005829cellular_componentcytosol
D0006396biological_processRNA processing
D0006397biological_processmRNA processing
D0008380biological_processRNA splicing
D0016607cellular_componentnuclear speck
D0046540cellular_componentU4/U6 x U5 tri-snRNP complex
D0071007cellular_componentU2-type catalytic step 2 spliceosome
D0071013cellular_componentcatalytic step 2 spliceosome
E0000354biological_processcis assembly of pre-catalytic spliceosome
E0000375biological_processRNA splicing, via transesterification reactions
E0000398biological_processmRNA splicing, via spliceosome
E0000785cellular_componentchromatin
E0003676molecular_functionnucleic acid binding
E0003689molecular_functionDNA clamp loader activity
E0003723molecular_functionRNA binding
E0003724molecular_functionRNA helicase activity
E0003729molecular_functionmRNA binding
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005681cellular_componentspliceosomal complex
E0005682cellular_componentU5 snRNP
E0005694cellular_componentchromosome
E0005730cellular_componentnucleolus
E0006397biological_processmRNA processing
E0008380biological_processRNA splicing
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0046540cellular_componentU4/U6 x U5 tri-snRNP complex
E0061775molecular_functioncohesin loader activity
E0062176biological_processR-loop processing
E0070062cellular_componentextracellular exosome
E0071013cellular_componentcatalytic step 2 spliceosome
E0140584molecular_functionchromatin extrusion motor activity
E0140588biological_processchromatin looping
E0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
E0140849molecular_functionATP-dependent H2AZ histone chaperone activity
F0000244biological_processspliceosomal tri-snRNP complex assembly
F0000245biological_processspliceosomal complex assembly
F0000375biological_processRNA splicing, via transesterification reactions
F0000398biological_processmRNA splicing, via spliceosome
F0003723molecular_functionRNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005681cellular_componentspliceosomal complex
F0005682cellular_componentU5 snRNP
F0006396biological_processRNA processing
F0006397biological_processmRNA processing
F0006403biological_processRNA localization
F0008380biological_processRNA splicing
F0016020cellular_componentmembrane
F0016607cellular_componentnuclear speck
F0030674molecular_functionprotein-macromolecule adaptor activity
F0042802molecular_functionidentical protein binding
F0043021molecular_functionribonucleoprotein complex binding
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046540cellular_componentU4/U6 x U5 tri-snRNP complex
F0071005cellular_componentU2-type precatalytic spliceosome
F0071013cellular_componentcatalytic step 2 spliceosome
G0000244biological_processspliceosomal tri-snRNP complex assembly
G0001650cellular_componentfibrillar center
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005682cellular_componentU5 snRNP
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006397biological_processmRNA processing
G0008380biological_processRNA splicing
G0016607cellular_componentnuclear speck
G0043021molecular_functionribonucleoprotein complex binding
G0046540cellular_componentU4/U6 x U5 tri-snRNP complex
a0000243cellular_componentcommitment complex
a0000245biological_processspliceosomal complex assembly
a0000387biological_processspliceosomal snRNP assembly
a0000398biological_processmRNA splicing, via spliceosome
a0003723molecular_functionRNA binding
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005681cellular_componentspliceosomal complex
a0005682cellular_componentU5 snRNP
a0005684cellular_componentU2-type spliceosomal complex
a0005685cellular_componentU1 snRNP
a0005686cellular_componentU2 snRNP
a0005687cellular_componentU4 snRNP
a0005689cellular_componentU12-type spliceosomal complex
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0006396biological_processRNA processing
a0006397biological_processmRNA processing
a0008380biological_processRNA splicing
a0030532cellular_componentsmall nuclear ribonucleoprotein complex
a0034709cellular_componentmethylosome
a0034715cellular_componentpICln-Sm protein complex
a0034719cellular_componentSMN-Sm protein complex
a0036261biological_process7-methylguanosine cap hypermethylation
a0046540cellular_componentU4/U6 x U5 tri-snRNP complex
a0071005cellular_componentU2-type precatalytic spliceosome
a0071007cellular_componentU2-type catalytic step 2 spliceosome
a0071011cellular_componentprecatalytic spliceosome
a0071013cellular_componentcatalytic step 2 spliceosome
a0097526cellular_componentspliceosomal tri-snRNP complex
a1903241biological_processU2-type prespliceosome assembly
a1990446molecular_functionU1 snRNP binding
b0000387biological_processspliceosomal snRNP assembly
b0000398biological_processmRNA splicing, via spliceosome
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005681cellular_componentspliceosomal complex
b0005682cellular_componentU5 snRNP
b0005683cellular_componentU7 snRNP
b0005684cellular_componentU2-type spliceosomal complex
b0005685cellular_componentU1 snRNP
b0005686cellular_componentU2 snRNP
b0005687cellular_componentU4 snRNP
b0005689cellular_componentU12-type spliceosomal complex
b0005697cellular_componenttelomerase holoenzyme complex
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0006397biological_processmRNA processing
b0006479biological_processprotein methylation
b0008380biological_processRNA splicing
b0030532cellular_componentsmall nuclear ribonucleoprotein complex
b0034709cellular_componentmethylosome
b0034719cellular_componentSMN-Sm protein complex
b0036261biological_process7-methylguanosine cap hypermethylation
b0046540cellular_componentU4/U6 x U5 tri-snRNP complex
b0070034molecular_functiontelomerase RNA binding
b0070990molecular_functionsnRNP binding
b0071004cellular_componentU2-type prespliceosome
b0071005cellular_componentU2-type precatalytic spliceosome
b0071007cellular_componentU2-type catalytic step 2 spliceosome
b0071013cellular_componentcatalytic step 2 spliceosome
b0071204cellular_componenthistone pre-mRNA 3'end processing complex
b0071208molecular_functionhistone pre-mRNA DCP binding
b1903241biological_processU2-type prespliceosome assembly
b1990446molecular_functionU1 snRNP binding
b1990447molecular_functionU2 snRNP binding
c0000245biological_processspliceosomal complex assembly
c0000387biological_processspliceosomal snRNP assembly
c0000398biological_processmRNA splicing, via spliceosome
c0003723molecular_functionRNA binding
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005681cellular_componentspliceosomal complex
c0005682cellular_componentU5 snRNP
c0005684cellular_componentU2-type spliceosomal complex
c0005685cellular_componentU1 snRNP
c0005686cellular_componentU2 snRNP
c0005687cellular_componentU4 snRNP
c0005689cellular_componentU12-type spliceosomal complex
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0006397biological_processmRNA processing
c0008380biological_processRNA splicing
c0030532cellular_componentsmall nuclear ribonucleoprotein complex
c0034709cellular_componentmethylosome
c0034715cellular_componentpICln-Sm protein complex
c0034719cellular_componentSMN-Sm protein complex
c0036261biological_process7-methylguanosine cap hypermethylation
c0046540cellular_componentU4/U6 x U5 tri-snRNP complex
c0070062cellular_componentextracellular exosome
c0071005cellular_componentU2-type precatalytic spliceosome
c0071007cellular_componentU2-type catalytic step 2 spliceosome
c0071011cellular_componentprecatalytic spliceosome
c0071013cellular_componentcatalytic step 2 spliceosome
c1903241biological_processU2-type prespliceosome assembly
d0000243cellular_componentcommitment complex
d0000387biological_processspliceosomal snRNP assembly
d0000398biological_processmRNA splicing, via spliceosome
d0003723molecular_functionRNA binding
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005681cellular_componentspliceosomal complex
d0005682cellular_componentU5 snRNP
d0005683cellular_componentU7 snRNP
d0005684cellular_componentU2-type spliceosomal complex
d0005685cellular_componentU1 snRNP
d0005686cellular_componentU2 snRNP
d0005687cellular_componentU4 snRNP
d0005689cellular_componentU12-type spliceosomal complex
d0005697cellular_componenttelomerase holoenzyme complex
d0005737cellular_componentcytoplasm
d0005829cellular_componentcytosol
d0006396biological_processRNA processing
d0006397biological_processmRNA processing
d0006479biological_processprotein methylation
d0008380biological_processRNA splicing
d0016604cellular_componentnuclear body
d0019899molecular_functionenzyme binding
d0030532cellular_componentsmall nuclear ribonucleoprotein complex
d0034709cellular_componentmethylosome
d0034715cellular_componentpICln-Sm protein complex
d0034719cellular_componentSMN-Sm protein complex
d0036261biological_process7-methylguanosine cap hypermethylation
d0046540cellular_componentU4/U6 x U5 tri-snRNP complex
d0070034molecular_functiontelomerase RNA binding
d0071005cellular_componentU2-type precatalytic spliceosome
d0071007cellular_componentU2-type catalytic step 2 spliceosome
d0071011cellular_componentprecatalytic spliceosome
d0071013cellular_componentcatalytic step 2 spliceosome
d0071208molecular_functionhistone pre-mRNA DCP binding
d0071209molecular_functionU7 snRNA binding
d0097526cellular_componentspliceosomal tri-snRNP complex
d1903241biological_processU2-type prespliceosome assembly
e0000245biological_processspliceosomal complex assembly
e0000387biological_processspliceosomal snRNP assembly
e0000398biological_processmRNA splicing, via spliceosome
e0003723molecular_functionRNA binding
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005681cellular_componentspliceosomal complex
e0005682cellular_componentU5 snRNP
e0005683cellular_componentU7 snRNP
e0005684cellular_componentU2-type spliceosomal complex
e0005685cellular_componentU1 snRNP
e0005686cellular_componentU2 snRNP
e0005687cellular_componentU4 snRNP
e0005689cellular_componentU12-type spliceosomal complex
e0005697cellular_componenttelomerase holoenzyme complex
e0005737cellular_componentcytoplasm
e0005829cellular_componentcytosol
e0006397biological_processmRNA processing
e0008380biological_processRNA splicing
e0030532cellular_componentsmall nuclear ribonucleoprotein complex
e0034709cellular_componentmethylosome
e0034715cellular_componentpICln-Sm protein complex
e0034719cellular_componentSMN-Sm protein complex
e0036261biological_process7-methylguanosine cap hypermethylation
e0046540cellular_componentU4/U6 x U5 tri-snRNP complex
e0071005cellular_componentU2-type precatalytic spliceosome
e0071007cellular_componentU2-type catalytic step 2 spliceosome
e0071011cellular_componentprecatalytic spliceosome
e0071013cellular_componentcatalytic step 2 spliceosome
e1903241biological_processU2-type prespliceosome assembly
f0000387biological_processspliceosomal snRNP assembly
f0000398biological_processmRNA splicing, via spliceosome
f0003723molecular_functionRNA binding
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005681cellular_componentspliceosomal complex
f0005682cellular_componentU5 snRNP
f0005683cellular_componentU7 snRNP
f0005684cellular_componentU2-type spliceosomal complex
f0005685cellular_componentU1 snRNP
f0005686cellular_componentU2 snRNP
f0005687cellular_componentU4 snRNP
f0005689cellular_componentU12-type spliceosomal complex
f0005737cellular_componentcytoplasm
f0005829cellular_componentcytosol
f0006397biological_processmRNA processing
f0008380biological_processRNA splicing
f0030532cellular_componentsmall nuclear ribonucleoprotein complex
f0034709cellular_componentmethylosome
f0034715cellular_componentpICln-Sm protein complex
f0034719cellular_componentSMN-Sm protein complex
f0036261biological_process7-methylguanosine cap hypermethylation
f0046540cellular_componentU4/U6 x U5 tri-snRNP complex
f0071005cellular_componentU2-type precatalytic spliceosome
f0071007cellular_componentU2-type catalytic step 2 spliceosome
f0071013cellular_componentcatalytic step 2 spliceosome
f0120114cellular_componentSm-like protein family complex
f1903241biological_processU2-type prespliceosome assembly
g0000245biological_processspliceosomal complex assembly
g0000387biological_processspliceosomal snRNP assembly
g0000398biological_processmRNA splicing, via spliceosome
g0003723molecular_functionRNA binding
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005654cellular_componentnucleoplasm
g0005681cellular_componentspliceosomal complex
g0005682cellular_componentU5 snRNP
g0005683cellular_componentU7 snRNP
g0005684cellular_componentU2-type spliceosomal complex
g0005685cellular_componentU1 snRNP
g0005686cellular_componentU2 snRNP
g0005687cellular_componentU4 snRNP
g0005689cellular_componentU12-type spliceosomal complex
g0005737cellular_componentcytoplasm
g0005829cellular_componentcytosol
g0006397biological_processmRNA processing
g0008380biological_processRNA splicing
g0030532cellular_componentsmall nuclear ribonucleoprotein complex
g0034709cellular_componentmethylosome
g0034719cellular_componentSMN-Sm protein complex
g0036261biological_process7-methylguanosine cap hypermethylation
g0043186cellular_componentP granule
g0046540cellular_componentU4/U6 x U5 tri-snRNP complex
g0071004cellular_componentU2-type prespliceosome
g0071005cellular_componentU2-type precatalytic spliceosome
g0071007cellular_componentU2-type catalytic step 2 spliceosome
g0071011cellular_componentprecatalytic spliceosome
g0071013cellular_componentcatalytic step 2 spliceosome
g0097526cellular_componentspliceosomal tri-snRNP complex
g1903241biological_processU2-type prespliceosome assembly
g1990446molecular_functionU1 snRNP binding
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmI
ChainResidueDetails
EVAL547-ILE555

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASAgfDrLILLWNV
ChainResidueDetails
DLEU81-VAL95
DLEU124-SER138
DVAL167-ILE181
DILE208-LEU222
DILE300-THR314

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0000269|Ref.6
ChainResidueDetails
fSER2
bARG112
CASN258

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
cSER9

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
cTHR12
DLYS270

site_idSWS_FT_FI4
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
cLYS6
GSER194
cLYS8

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER195
BTHR1428
ELYS811

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
GLYS26

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS971

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P4T2
ChainResidueDetails
BTHR1765

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER2002

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
BTHR2131

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
BSER2133
BSER2135

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS46

227111

PDB entries from 2024-11-06

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