8Q7T
Tau - AD-MIA11
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0015631 | molecular_function | tubulin binding |
| B | 0008017 | molecular_function | microtubule binding |
| B | 0015631 | molecular_function | tubulin binding |
| C | 0008017 | molecular_function | microtubule binding |
| C | 0015631 | molecular_function | tubulin binding |
| D | 0008017 | molecular_function | microtubule binding |
| D | 0015631 | molecular_function | tubulin binding |
| E | 0008017 | molecular_function | microtubule binding |
| E | 0015631 | molecular_function | tubulin binding |
| F | 0008017 | molecular_function | microtubule binding |
| F | 0015631 | molecular_function | tubulin binding |
| G | 0008017 | molecular_function | microtubule binding |
| G | 0015631 | molecular_function | tubulin binding |
| H | 0008017 | molecular_function | microtubule binding |
| H | 0015631 | molecular_function | tubulin binding |
| I | 0008017 | molecular_function | microtubule binding |
| I | 0015631 | molecular_function | tubulin binding |
Functional Information from PROSITE/UniProt
| site_id | PS00229 |
| Number of Residues | 13 |
| Details | TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG |
| Chain | Residue | Details |
| B | GLY261-GLY273 | |
| B | GLY292-GLY304 | |
| B | GLY323-GLY335 | |
| B | GLY355-GLY367 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 252 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| B | LYS83 | |
| B | LYS103 | |
| B | ARG126 | |
| B | GLY440 | |
| B | LYS148 | |
| B | LYS180 | |
| B | LYS190 | |
| B | LYS240 | |
| B | LYS254 | |
| B | LYS257 | |
| B | LYS267 | |
| B | LYS274 | |
| B | LYS290 | |
| B | LYS294 | |
| B | LYS311 | |
| B | LYS317 | |
| B | LYS321 | |
| B | LYS331 | |
| B | LYS383 | |
| B | LYS385 | |
| B | LYS395 | |
| B | LYS438 | |
| D | LYS83 | |
| D | LYS103 | |
| D | ARG126 | |
| D | GLY440 | |
| D | LYS148 | |
| D | LYS180 | |
| D | LYS190 | |
| D | LYS224 | |
| D | LYS240 | |
| D | LYS254 | |
| D | LYS257 | |
| D | LYS267 | |
| D | LYS274 | |
| D | LYS290 | |
| D | LYS294 | |
| D | LYS298 | |
| D | LYS311 | |
| D | LYS317 | |
| D | LYS321 | |
| D | LYS331 | |
| D | LYS340 | |
| D | LYS343 | |
| D | LYS370 | |
| D | LYS375 | |
| D | LYS383 | |
| D | LYS385 | |
| D | LYS395 | |
| D | LYS438 | |
| F | LYS83 | |
| F | LYS103 | |
| F | ARG126 | |
| F | GLY440 | |
| F | LYS148 | |
| F | LYS180 | |
| F | LYS190 | |
| F | LYS224 | |
| F | LYS240 | |
| F | LYS254 | |
| F | LYS257 | |
| F | LYS267 | |
| F | LYS274 | |
| F | LYS290 | |
| F | LYS294 | |
| F | LYS298 | |
| F | LYS311 | |
| F | LYS317 | |
| F | LYS321 | |
| F | LYS331 | |
| F | LYS340 | |
| F | LYS343 | |
| F | LYS370 | |
| F | LYS375 | |
| F | LYS383 | |
| F | LYS385 | |
| F | LYS395 | |
| F | LYS438 | |
| C | LYS83 | |
| C | LYS103 | |
| C | ARG126 | |
| C | GLY440 | |
| C | LYS148 | |
| C | LYS180 | |
| C | LYS190 | |
| C | LYS224 | |
| C | LYS240 | |
| C | LYS254 | |
| C | LYS257 | |
| C | LYS267 | |
| C | LYS274 | |
| C | LYS290 | |
| C | LYS294 | |
| C | LYS298 | |
| C | LYS311 | |
| C | LYS317 | |
| C | LYS321 | |
| C | LYS331 | |
| C | LYS340 | |
| C | LYS343 | |
| C | LYS370 | |
| C | LYS375 | |
| C | LYS383 | |
| C | LYS385 | |
| C | LYS395 | |
| C | LYS438 | |
| A | LYS83 | |
| A | LYS103 | |
| A | ARG126 | |
| A | GLY440 | |
| A | LYS148 | |
| A | LYS180 | |
| A | LYS190 | |
| A | LYS224 | |
| A | LYS240 | |
| A | LYS254 | |
| A | LYS257 | |
| A | LYS267 | |
| A | LYS274 | |
| A | LYS290 | |
| A | LYS294 | |
| A | LYS298 | |
| A | LYS311 | |
| A | LYS317 | |
| A | LYS321 | |
| A | LYS331 | |
| A | LYS340 | |
| A | LYS343 | |
| A | LYS370 | |
| A | LYS375 | |
| A | LYS383 | |
| A | LYS385 | |
| A | LYS395 | |
| A | LYS438 | |
| E | LYS83 | |
| E | LYS103 | |
| E | ARG126 | |
| E | GLY440 | |
| E | LYS148 | |
| E | LYS180 | |
| E | LYS190 | |
| E | LYS224 | |
| E | LYS240 | |
| E | LYS254 | |
| E | LYS257 | |
| E | LYS267 | |
| E | LYS274 | |
| E | LYS290 | |
| E | LYS294 | |
| E | LYS298 | |
| E | LYS311 | |
| E | LYS317 | |
| E | LYS321 | |
| E | LYS331 | |
| E | LYS340 | |
| E | LYS343 | |
| E | LYS370 | |
| E | LYS375 | |
| E | LYS383 | |
| E | LYS385 | |
| E | LYS395 | |
| E | LYS438 | |
| G | LYS83 | |
| G | LYS103 | |
| G | ARG126 | |
| G | GLY440 | |
| G | LYS148 | |
| G | LYS180 | |
| G | LYS190 | |
| G | LYS224 | |
| G | LYS240 | |
| G | LYS254 | |
| G | LYS257 | |
| G | LYS267 | |
| G | LYS274 | |
| G | LYS290 | |
| G | LYS294 | |
| G | LYS298 | |
| G | LYS311 | |
| G | LYS317 | |
| G | LYS321 | |
| G | LYS331 | |
| G | LYS340 | |
| G | LYS343 | |
| G | LYS370 | |
| G | LYS375 | |
| G | LYS383 | |
| G | LYS385 | |
| G | LYS395 | |
| G | LYS438 | |
| H | LYS83 | |
| H | LYS103 | |
| H | ARG126 | |
| H | GLY440 | |
| H | LYS148 | |
| H | LYS180 | |
| H | LYS190 | |
| H | LYS224 | |
| H | LYS240 | |
| H | LYS254 | |
| H | LYS257 | |
| H | LYS267 | |
| H | LYS274 | |
| H | LYS290 | |
| H | LYS294 | |
| H | LYS298 | |
| H | LYS311 | |
| H | LYS317 | |
| H | LYS321 | |
| H | LYS331 | |
| H | LYS340 | |
| H | LYS343 | |
| H | LYS370 | |
| H | LYS375 | |
| H | LYS383 | |
| H | LYS385 | |
| H | LYS395 | |
| H | LYS438 | |
| I | LYS83 | |
| I | LYS103 | |
| I | ARG126 | |
| I | GLY440 | |
| I | LYS148 | |
| I | LYS180 | |
| I | LYS190 | |
| I | LYS224 | |
| I | LYS240 | |
| I | LYS254 | |
| I | LYS257 | |
| I | LYS267 | |
| I | LYS274 | |
| I | LYS290 | |
| I | LYS294 | |
| I | LYS298 | |
| I | LYS311 | |
| I | LYS317 | |
| I | LYS321 | |
| I | LYS331 | |
| I | LYS340 | |
| I | LYS343 | |
| I | LYS370 | |
| I | LYS375 | |
| I | LYS383 | |
| I | LYS385 | |
| I | LYS395 | |
| I | LYS438 | |
| B | LYS224 | |
| B | LYS298 | |
| B | LYS340 | |
| B | LYS343 | |
| B | LYS370 | |
| B | LYS375 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244 |
| Chain | Residue | Details |
| B | ALA61 | |
| D | ALA61 | |
| F | ALA61 | |
| C | ALA61 | |
| A | ALA61 | |
| E | ALA61 | |
| G | ALA61 | |
| H | ALA61 | |
| I | ALA61 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081 |
| Chain | Residue | Details |
| B | TYR77 | |
| D | TYR77 | |
| F | TYR77 | |
| C | TYR77 | |
| A | TYR77 | |
| E | TYR77 | |
| G | TYR77 | |
| H | TYR77 | |
| I | TYR77 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | TYR88 | |
| D | TYR88 | |
| F | TYR88 | |
| C | TYR88 | |
| A | TYR88 | |
| A | TYR394 | |
| E | TYR88 | |
| E | TYR394 | |
| G | TYR88 | |
| G | TYR394 | |
| H | TYR88 | |
| H | TYR394 | |
| I | TYR88 | |
| I | TYR394 | |
| B | TYR394 | |
| D | TYR394 | |
| F | TYR394 | |
| C | TYR394 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332 |
| Chain | Residue | Details |
| B | GLU105 | |
| B | GLY120 | |
| D | GLU105 | |
| D | GLY120 | |
| F | GLU105 | |
| F | GLY120 | |
| C | GLU105 | |
| C | GLY120 | |
| A | GLU105 | |
| A | GLY120 | |
| E | GLU105 | |
| E | GLY120 | |
| G | GLU105 | |
| G | GLY120 | |
| H | GLU105 | |
| H | GLY120 | |
| I | GLU105 | |
| I | GLY120 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 45 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | VAL128 | |
| B | ARG170 | |
| B | THR175 | |
| D | ARG170 | |
| D | THR169 | |
| D | THR175 | |
| F | THR169 | |
| F | THR175 | |
| F | THR403 | |
| C | VAL128 | |
| C | ARG170 | |
| C | THR169 | |
| C | THR175 | |
| C | THR403 | |
| A | VAL128 | |
| A | ARG170 | |
| A | THR169 | |
| A | THR175 | |
| A | THR403 | |
| E | VAL128 | |
| E | ARG170 | |
| E | THR169 | |
| E | THR175 | |
| E | THR403 | |
| G | VAL128 | |
| G | ARG170 | |
| G | THR169 | |
| G | THR175 | |
| G | THR403 | |
| H | VAL128 | |
| H | ARG170 | |
| H | THR169 | |
| H | THR175 | |
| H | THR403 | |
| I | VAL128 | |
| I | ARG170 | |
| I | THR169 | |
| I | THR175 | |
| I | THR403 | |
| B | THR169 | |
| B | THR403 | |
| D | VAL128 | |
| D | THR403 | |
| F | VAL128 | |
| F | ARG170 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332 |
| Chain | Residue | Details |
| B | LYS130 | |
| D | LYS130 | |
| F | LYS130 | |
| C | LYS130 | |
| A | LYS130 | |
| E | LYS130 | |
| G | LYS130 | |
| H | LYS130 | |
| I | LYS130 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696 |
| Chain | Residue | Details |
| B | GLY273 | |
| D | GLY273 | |
| F | GLY273 | |
| C | GLY273 | |
| A | GLY273 | |
| E | GLY273 | |
| G | GLY273 | |
| H | GLY273 | |
| I | GLY273 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| F | THR153 | |
| G | THR153 | |
| D | THR153 | |
| C | THR153 | |
| E | THR153 | |
| H | THR153 | |
| B | THR153 | |
| A | THR153 | |
| I | THR153 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| D | ARG155 | |
| C | ARG155 | |
| G | ARG155 | |
| H | ARG155 | |
| I | ARG155 | |
| B | ARG349 | |
| D | ARG349 | |
| F | ARG349 | |
| C | ARG349 | |
| A | ARG349 | |
| E | ARG349 | |
| G | ARG349 | |
| H | ARG349 | |
| I | ARG349 | |
| B | ARG155 | |
| F | ARG155 | |
| A | ARG155 | |
| E | ARG155 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 99 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | LYS163 | |
| B | LYS281 | |
| B | LYS298 | |
| B | LYS311 | |
| B | LYS317 | |
| B | LYS321 | |
| B | LYS331 | |
| B | LYS343 | |
| B | LYS347 | |
| B | LYS369 | |
| B | LYS385 | |
| D | LYS163 | |
| D | LYS281 | |
| D | LYS298 | |
| D | LYS311 | |
| D | LYS317 | |
| D | LYS321 | |
| D | LYS331 | |
| D | LYS343 | |
| D | LYS347 | |
| D | LYS369 | |
| D | LYS385 | |
| F | LYS163 | |
| F | LYS281 | |
| F | LYS298 | |
| F | LYS311 | |
| F | LYS317 | |
| F | LYS321 | |
| F | LYS331 | |
| F | LYS343 | |
| F | LYS347 | |
| F | LYS369 | |
| F | LYS385 | |
| C | LYS163 | |
| C | LYS281 | |
| C | LYS298 | |
| C | LYS311 | |
| C | LYS317 | |
| C | LYS321 | |
| C | LYS331 | |
| C | LYS343 | |
| C | LYS347 | |
| C | LYS369 | |
| C | LYS385 | |
| A | LYS163 | |
| A | LYS281 | |
| A | LYS298 | |
| A | LYS311 | |
| A | LYS317 | |
| A | LYS321 | |
| A | LYS331 | |
| A | LYS343 | |
| A | LYS347 | |
| A | LYS369 | |
| A | LYS385 | |
| E | LYS163 | |
| E | LYS281 | |
| E | LYS298 | |
| E | LYS311 | |
| E | LYS317 | |
| E | LYS321 | |
| E | LYS331 | |
| E | LYS343 | |
| E | LYS347 | |
| E | LYS369 | |
| E | LYS385 | |
| G | LYS163 | |
| G | LYS281 | |
| G | LYS298 | |
| G | LYS311 | |
| G | LYS317 | |
| G | LYS321 | |
| G | LYS331 | |
| G | LYS343 | |
| G | LYS347 | |
| G | LYS369 | |
| G | LYS385 | |
| H | LYS163 | |
| H | LYS281 | |
| H | LYS298 | |
| H | LYS311 | |
| H | LYS317 | |
| H | LYS321 | |
| H | LYS331 | |
| H | LYS343 | |
| H | LYS347 | |
| H | LYS369 | |
| H | LYS385 | |
| I | LYS163 | |
| I | LYS281 | |
| I | LYS298 | |
| I | LYS311 | |
| I | LYS317 | |
| I | LYS321 | |
| I | LYS331 | |
| I | LYS343 | |
| I | LYS347 | |
| I | LYS369 | |
| I | LYS385 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | MOD_RES: Deamidated asparagine; in tau and PHF-tau; partial => ECO:0000269|PubMed:1512244 |
| Chain | Residue | Details |
| B | ASN167 | |
| B | ASN279 | |
| D | ASN167 | |
| D | ASN279 | |
| F | ASN167 | |
| F | ASN279 | |
| C | ASN167 | |
| C | ASN279 | |
| A | ASN167 | |
| A | ASN279 | |
| E | ASN167 | |
| E | ASN279 | |
| G | ASN167 | |
| G | ASN279 | |
| H | ASN167 | |
| H | ASN279 | |
| I | ASN167 | |
| I | ASN279 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:15546861 |
| Chain | Residue | Details |
| B | THR181 | |
| D | THR181 | |
| F | THR181 | |
| C | THR181 | |
| A | THR181 | |
| E | THR181 | |
| G | THR181 | |
| H | THR181 | |
| I | THR181 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 27 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | SER185 | |
| B | SER191 | |
| B | SER195 | |
| D | SER185 | |
| D | SER191 | |
| D | SER195 | |
| F | SER185 | |
| F | SER191 | |
| F | SER195 | |
| C | SER185 | |
| C | SER191 | |
| C | SER195 | |
| A | SER185 | |
| A | SER191 | |
| A | SER195 | |
| E | SER185 | |
| E | SER191 | |
| E | SER195 | |
| G | SER185 | |
| G | SER191 | |
| G | SER195 | |
| H | SER185 | |
| H | SER191 | |
| H | SER195 | |
| I | SER185 | |
| I | SER191 | |
| I | SER195 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphotyrosine; by TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| B | TYR197 | |
| D | TYR197 | |
| F | TYR197 | |
| C | TYR197 | |
| A | TYR197 | |
| E | TYR197 | |
| G | TYR197 | |
| H | TYR197 | |
| I | TYR197 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| B | SER198 | |
| D | SER198 | |
| F | SER198 | |
| C | SER198 | |
| A | SER198 | |
| E | SER198 | |
| G | SER198 | |
| H | SER198 | |
| I | SER198 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| B | SER199 | |
| D | SER199 | |
| F | SER199 | |
| C | SER199 | |
| A | SER199 | |
| E | SER199 | |
| G | SER199 | |
| H | SER199 | |
| I | SER199 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by CK1, PDPK1 and TTBK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER202 | |
| D | SER202 | |
| F | SER202 | |
| C | SER202 | |
| A | SER202 | |
| E | SER202 | |
| G | SER202 | |
| H | SER202 | |
| I | SER202 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179 |
| Chain | Residue | Details |
| B | THR205 | |
| D | THR205 | |
| F | THR205 | |
| C | THR205 | |
| A | THR205 | |
| E | THR205 | |
| G | THR205 | |
| H | THR205 | |
| I | THR205 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| B | THR212 | |
| D | THR212 | |
| F | THR212 | |
| C | THR212 | |
| A | THR212 | |
| E | THR212 | |
| G | THR212 | |
| H | THR212 | |
| I | THR212 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| B | SER214 | |
| D | SER214 | |
| F | SER214 | |
| C | SER214 | |
| A | SER214 | |
| E | SER214 | |
| G | SER214 | |
| H | SER214 | |
| I | SER214 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179 |
| Chain | Residue | Details |
| B | THR217 | |
| D | THR217 | |
| F | THR217 | |
| C | THR217 | |
| A | THR217 | |
| E | THR217 | |
| G | THR217 | |
| H | THR217 | |
| I | THR217 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | LYS225 | |
| B | LYS290 | |
| D | LYS225 | |
| D | LYS290 | |
| F | LYS225 | |
| F | LYS290 | |
| C | LYS225 | |
| C | LYS290 | |
| A | LYS225 | |
| A | LYS290 | |
| E | LYS225 | |
| E | LYS290 | |
| G | LYS225 | |
| G | LYS290 | |
| H | LYS225 | |
| H | LYS290 | |
| I | LYS225 | |
| I | LYS290 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR231 | |
| D | THR231 | |
| F | THR231 | |
| C | THR231 | |
| A | THR231 | |
| E | THR231 | |
| G | THR231 | |
| H | THR231 | |
| I | THR231 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER235 | |
| D | SER235 | |
| F | SER235 | |
| C | SER235 | |
| A | SER235 | |
| E | SER235 | |
| G | SER235 | |
| H | SER235 | |
| I | SER235 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| B | SER237 | |
| D | SER237 | |
| F | SER237 | |
| C | SER237 | |
| A | SER237 | |
| E | SER237 | |
| G | SER237 | |
| H | SER237 | |
| I | SER237 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 9 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | LYS259 | |
| D | LYS259 | |
| F | LYS259 | |
| C | LYS259 | |
| A | LYS259 | |
| E | LYS259 | |
| G | LYS259 | |
| H | LYS259 | |
| I | LYS259 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by MARK1, MARK2, MARK3, MARK4, BRSK1, BRSK2 and PHK => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| B | SER262 | |
| D | SER262 | |
| F | SER262 | |
| C | SER262 | |
| A | SER262 | |
| E | SER262 | |
| G | SER262 | |
| H | SER262 | |
| I | SER262 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 18 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| B | SER285 | |
| B | SER352 | |
| D | SER285 | |
| D | SER352 | |
| F | SER285 | |
| F | SER352 | |
| C | SER285 | |
| C | SER352 | |
| A | SER285 | |
| A | SER352 | |
| E | SER285 | |
| E | SER352 | |
| G | SER285 | |
| G | SER352 | |
| H | SER285 | |
| H | SER352 | |
| I | SER285 | |
| I | SER352 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 27 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316 |
| Chain | Residue | Details |
| B | SER293 | |
| B | SER324 | |
| B | SER356 | |
| D | SER293 | |
| D | SER324 | |
| D | SER356 | |
| F | SER293 | |
| F | SER324 | |
| F | SER356 | |
| C | SER293 | |
| C | SER324 | |
| C | SER356 | |
| A | SER293 | |
| A | SER324 | |
| A | SER356 | |
| E | SER293 | |
| E | SER324 | |
| E | SER356 | |
| G | SER293 | |
| G | SER324 | |
| G | SER356 | |
| H | SER293 | |
| H | SER324 | |
| H | SER356 | |
| I | SER293 | |
| I | SER324 | |
| I | SER356 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| B | SER305 | |
| D | SER305 | |
| F | SER305 | |
| C | SER305 | |
| A | SER305 | |
| E | SER305 | |
| G | SER305 | |
| H | SER305 | |
| I | SER305 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER396 | |
| D | SER396 | |
| F | SER396 | |
| C | SER396 | |
| A | SER396 | |
| E | SER396 | |
| G | SER396 | |
| H | SER396 | |
| I | SER396 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | SER400 | |
| D | SER400 | |
| F | SER400 | |
| C | SER400 | |
| A | SER400 | |
| E | SER400 | |
| G | SER400 | |
| H | SER400 | |
| I | SER400 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER404 | |
| D | SER404 | |
| F | SER404 | |
| C | SER404 | |
| A | SER404 | |
| E | SER404 | |
| G | SER404 | |
| H | SER404 | |
| I | SER404 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15546861, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | SER409 | |
| D | SER409 | |
| F | SER409 | |
| C | SER409 | |
| A | SER409 | |
| E | SER409 | |
| G | SER409 | |
| H | SER409 | |
| I | SER409 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by CaMK2 and TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| B | SER416 | |
| D | SER416 | |
| F | SER416 | |
| C | SER416 | |
| A | SER416 | |
| E | SER416 | |
| G | SER416 | |
| H | SER416 | |
| I | SER416 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| B | SER422 | |
| D | SER422 | |
| F | SER422 | |
| C | SER422 | |
| A | SER422 | |
| E | SER422 | |
| G | SER422 | |
| H | SER422 | |
| I | SER422 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| B | THR427 | |
| D | THR427 | |
| F | THR427 | |
| C | THR427 | |
| A | THR427 | |
| E | THR427 | |
| G | THR427 | |
| H | THR427 | |
| I | THR427 |
| site_id | SWS_FT_FI39 |
| Number of Residues | 117 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| B | ASP146 | |
| B | LYS150 | |
| B | LYS163 | |
| B | LYS174 | |
| B | LYS225 | |
| B | LYS234 | |
| B | LYS259 | |
| B | LYS280 | |
| B | LYS281 | |
| B | LYS347 | |
| B | LYS353 | |
| B | LYS369 | |
| D | ASP146 | |
| D | LYS150 | |
| D | LYS163 | |
| D | LYS174 | |
| D | LYS225 | |
| D | LYS234 | |
| D | LYS259 | |
| D | LYS280 | |
| D | LYS281 | |
| D | LYS347 | |
| D | LYS353 | |
| D | LYS369 | |
| F | ASP146 | |
| F | LYS150 | |
| F | LYS163 | |
| F | LYS174 | |
| F | LYS225 | |
| F | LYS234 | |
| F | LYS259 | |
| F | LYS280 | |
| F | LYS281 | |
| F | LYS347 | |
| F | LYS353 | |
| F | LYS369 | |
| C | ASP146 | |
| C | LYS150 | |
| C | LYS163 | |
| C | LYS174 | |
| C | LYS225 | |
| C | LYS234 | |
| C | LYS259 | |
| C | LYS280 | |
| C | LYS281 | |
| C | LYS347 | |
| C | LYS353 | |
| C | LYS369 | |
| A | ASP146 | |
| A | LYS150 | |
| A | LYS163 | |
| A | LYS174 | |
| A | LYS225 | |
| A | LYS234 | |
| A | LYS259 | |
| A | LYS280 | |
| A | LYS281 | |
| A | LYS347 | |
| A | LYS353 | |
| A | LYS369 | |
| E | ASP146 | |
| E | LYS150 | |
| E | LYS163 | |
| E | LYS174 | |
| E | LYS225 | |
| E | LYS234 | |
| E | LYS259 | |
| E | LYS280 | |
| E | LYS281 | |
| E | LYS347 | |
| E | LYS353 | |
| E | LYS369 | |
| G | ASP146 | |
| G | LYS150 | |
| G | LYS163 | |
| G | LYS174 | |
| G | LYS225 | |
| G | LYS234 | |
| G | LYS259 | |
| G | LYS280 | |
| G | LYS281 | |
| G | LYS347 | |
| G | LYS353 | |
| G | LYS369 | |
| H | ASP146 | |
| H | LYS150 | |
| H | LYS163 | |
| H | LYS174 | |
| H | LYS225 | |
| H | LYS234 | |
| H | LYS259 | |
| H | LYS280 | |
| H | LYS281 | |
| H | LYS347 | |
| H | LYS353 | |
| H | LYS369 | |
| I | ASP146 | |
| I | LYS150 | |
| I | LYS163 | |
| I | LYS174 | |
| I | LYS225 | |
| I | LYS234 | |
| I | LYS259 | |
| I | LYS280 | |
| I | LYS281 | |
| I | LYS347 | |
| I | LYS353 | |
| I | LYS369 |
| site_id | SWS_FT_FI40 |
| Number of Residues | 18 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| B | SER208 | |
| B | SER238 | |
| D | SER208 | |
| D | SER238 | |
| F | SER208 | |
| F | SER238 | |
| C | SER208 | |
| C | SER238 | |
| A | SER208 | |
| A | SER238 | |
| E | SER208 | |
| E | SER238 | |
| G | SER208 | |
| G | SER238 | |
| H | SER208 | |
| H | SER238 | |
| I | SER208 | |
| I | SER238 |
| site_id | SWS_FT_FI41 |
| Number of Residues | 9 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| B | SER400 | |
| D | SER400 | |
| F | SER400 | |
| C | SER400 | |
| A | SER400 | |
| E | SER400 | |
| G | SER400 | |
| H | SER400 | |
| I | SER400 |
| site_id | SWS_FT_FI42 |
| Number of Residues | 27 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | LYS103 | |
| B | LYS267 | |
| B | LYS375 | |
| D | LYS103 | |
| D | LYS267 | |
| D | LYS375 | |
| F | LYS103 | |
| F | LYS267 | |
| F | LYS375 | |
| C | LYS103 | |
| C | LYS267 | |
| C | LYS375 | |
| A | LYS103 | |
| A | LYS267 | |
| A | LYS375 | |
| E | LYS103 | |
| E | LYS267 | |
| E | LYS375 | |
| G | LYS103 | |
| G | LYS267 | |
| G | LYS375 | |
| H | LYS103 | |
| H | LYS267 | |
| H | LYS375 | |
| I | LYS103 | |
| I | LYS267 | |
| I | LYS375 |
| site_id | SWS_FT_FI43 |
| Number of Residues | 99 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| B | LYS259 | |
| B | LYS281 | |
| B | LYS298 | |
| B | LYS317 | |
| B | LYS321 | |
| B | LYS331 | |
| B | LYS343 | |
| B | LYS347 | |
| B | LYS369 | |
| B | LYS385 | |
| D | LYS259 | |
| D | LYS281 | |
| D | LYS298 | |
| D | LYS317 | |
| D | LYS321 | |
| D | LYS331 | |
| D | LYS343 | |
| D | LYS347 | |
| D | LYS369 | |
| D | LYS385 | |
| F | LYS259 | |
| F | LYS281 | |
| F | LYS298 | |
| F | LYS317 | |
| F | LYS321 | |
| F | LYS331 | |
| F | LYS343 | |
| F | LYS347 | |
| F | LYS369 | |
| F | LYS385 | |
| C | LYS259 | |
| C | LYS281 | |
| C | LYS298 | |
| C | LYS317 | |
| C | LYS321 | |
| C | LYS331 | |
| C | LYS343 | |
| C | LYS347 | |
| C | LYS369 | |
| C | LYS385 | |
| A | LYS259 | |
| A | LYS281 | |
| A | LYS298 | |
| A | LYS317 | |
| A | LYS321 | |
| A | LYS331 | |
| A | LYS343 | |
| A | LYS347 | |
| A | LYS369 | |
| A | LYS385 | |
| E | LYS259 | |
| E | LYS281 | |
| E | LYS298 | |
| E | LYS317 | |
| E | LYS321 | |
| E | LYS331 | |
| E | LYS343 | |
| E | LYS347 | |
| E | LYS369 | |
| E | LYS385 | |
| G | LYS259 | |
| G | LYS281 | |
| G | LYS298 | |
| G | LYS317 | |
| G | LYS321 | |
| G | LYS331 | |
| G | LYS343 | |
| G | LYS347 | |
| G | LYS369 | |
| G | LYS385 | |
| H | LYS259 | |
| H | LYS281 | |
| H | LYS298 | |
| H | LYS317 | |
| H | LYS321 | |
| H | LYS331 | |
| H | LYS343 | |
| H | LYS347 | |
| H | LYS369 | |
| H | LYS385 | |
| I | LYS259 | |
| I | LYS281 | |
| I | LYS298 | |
| I | LYS317 | |
| I | LYS321 | |
| I | LYS331 | |
| I | LYS343 | |
| I | LYS347 | |
| I | LYS369 | |
| I | LYS385 |
| site_id | SWS_FT_FI44 |
| Number of Residues | 27 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| B | LYS254 | |
| B | LYS311 | |
| B | LYS353 | |
| D | LYS254 | |
| D | LYS311 | |
| D | LYS353 | |
| F | LYS254 | |
| F | LYS311 | |
| F | LYS353 | |
| C | LYS254 | |
| C | LYS311 | |
| C | LYS353 | |
| A | LYS254 | |
| A | LYS311 | |
| A | LYS353 | |
| E | LYS254 | |
| E | LYS311 | |
| E | LYS353 | |
| G | LYS254 | |
| G | LYS311 | |
| G | LYS353 | |
| H | LYS254 | |
| H | LYS311 | |
| H | LYS353 | |
| I | LYS254 | |
| I | LYS311 | |
| I | LYS353 |
