Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8Q7E

Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007088	biological_process	regulation of mitotic nuclear division
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031461	cellular_component	cullin-RING ubiquitin ligase complex
A	0046872	molecular_function	metal ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
B	0000226	biological_process	microtubule cytoskeleton organization
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007088	biological_process	regulation of mitotic nuclear division
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0046872	molecular_function	metal ion binding
B	0061630	molecular_function	ubiquitin protein ligase activity
C	0000165	biological_process	MAPK cascade
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006974	biological_process	DNA damage response
C	0007283	biological_process	spermatogenesis
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0019788	molecular_function	NEDD8 transferase activity
C	0030163	biological_process	protein catabolic process
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032480	biological_process	negative regulation of type I interferon production
C	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
C	0034644	biological_process	cellular response to UV
C	0042110	biological_process	T cell activation
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043687	biological_process	post-translational protein modification
C	0045116	biological_process	protein neddylation
C	0045732	biological_process	positive regulation of protein catabolic process
C	0046872	molecular_function	metal ion binding
C	0060090	molecular_function	molecular adaptor activity
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061663	molecular_function	NEDD8 ligase activity
C	0062197	biological_process	cellular response to chemical stress
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0097602	molecular_function	cullin family protein binding
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1902499	biological_process	positive regulation of protein autoubiquitination
C	1902883	biological_process	negative regulation of response to oxidative stress
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034644	biological_process	cellular response to UV
D	0042110	biological_process	T cell activation
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0045116	biological_process	protein neddylation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0000226	biological_process	microtubule cytoskeleton organization
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007088	biological_process	regulation of mitotic nuclear division
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0046872	molecular_function	metal ion binding
E	0061630	molecular_function	ubiquitin protein ligase activity
F	0000226	biological_process	microtubule cytoskeleton organization
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007088	biological_process	regulation of mitotic nuclear division
F	0016567	biological_process	protein ubiquitination
F	0016740	molecular_function	transferase activity
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0046872	molecular_function	metal ion binding
F	0061630	molecular_function	ubiquitin protein ligase activity
G	0000165	biological_process	MAPK cascade
G	0000209	biological_process	protein polyubiquitination
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006513	biological_process	protein monoubiquitination
G	0006974	biological_process	DNA damage response
G	0007283	biological_process	spermatogenesis
G	0016567	biological_process	protein ubiquitination
G	0016740	molecular_function	transferase activity
G	0019005	cellular_component	SCF ubiquitin ligase complex
G	0019788	molecular_function	NEDD8 transferase activity
G	0030163	biological_process	protein catabolic process
G	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
G	0031461	cellular_component	cullin-RING ubiquitin ligase complex
G	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
G	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
G	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
G	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
G	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
G	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0032480	biological_process	negative regulation of type I interferon production
G	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
G	0034644	biological_process	cellular response to UV
G	0042110	biological_process	T cell activation
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043687	biological_process	post-translational protein modification
G	0045116	biological_process	protein neddylation
G	0045732	biological_process	positive regulation of protein catabolic process
G	0046872	molecular_function	metal ion binding
G	0060090	molecular_function	molecular adaptor activity
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0061663	molecular_function	NEDD8 ligase activity
G	0062197	biological_process	cellular response to chemical stress
G	0070936	biological_process	protein K48-linked ubiquitination
G	0071230	biological_process	cellular response to amino acid stimulus
G	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
G	0097602	molecular_function	cullin family protein binding
G	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
G	1900076	biological_process	regulation of cellular response to insulin stimulus
G	1902499	biological_process	positive regulation of protein autoubiquitination
G	1902883	biological_process	negative regulation of response to oxidative stress
G	1904263	biological_process	positive regulation of TORC1 signaling
H	0000165	biological_process	MAPK cascade
H	0000209	biological_process	protein polyubiquitination
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006281	biological_process	DNA repair
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006974	biological_process	DNA damage response
H	0007283	biological_process	spermatogenesis
H	0016567	biological_process	protein ubiquitination
H	0016740	molecular_function	transferase activity
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019788	molecular_function	NEDD8 transferase activity
H	0030163	biological_process	protein catabolic process
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
H	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0032480	biological_process	negative regulation of type I interferon production
H	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
H	0034644	biological_process	cellular response to UV
H	0042110	biological_process	T cell activation
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043687	biological_process	post-translational protein modification
H	0045116	biological_process	protein neddylation
H	0045732	biological_process	positive regulation of protein catabolic process
H	0046872	molecular_function	metal ion binding
H	0060090	molecular_function	molecular adaptor activity
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0061663	molecular_function	NEDD8 ligase activity
H	0062197	biological_process	cellular response to chemical stress
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071230	biological_process	cellular response to amino acid stimulus
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0097602	molecular_function	cullin family protein binding
H	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
H	1900076	biological_process	regulation of cellular response to insulin stimulus
H	1902499	biological_process	positive regulation of protein autoubiquitination
H	1902883	biological_process	negative regulation of response to oxidative stress
H	1904263	biological_process	positive regulation of TORC1 signaling
I	0000226	biological_process	microtubule cytoskeleton organization
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0007088	biological_process	regulation of mitotic nuclear division
I	0016567	biological_process	protein ubiquitination
I	0016740	molecular_function	transferase activity
I	0031461	cellular_component	cullin-RING ubiquitin ligase complex
I	0046872	molecular_function	metal ion binding
I	0061630	molecular_function	ubiquitin protein ligase activity
J	0000226	biological_process	microtubule cytoskeleton organization
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0007088	biological_process	regulation of mitotic nuclear division
J	0016567	biological_process	protein ubiquitination
J	0016740	molecular_function	transferase activity
J	0031461	cellular_component	cullin-RING ubiquitin ligase complex
J	0046872	molecular_function	metal ion binding
J	0061630	molecular_function	ubiquitin protein ligase activity
K	0000165	biological_process	MAPK cascade
K	0000209	biological_process	protein polyubiquitination
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006513	biological_process	protein monoubiquitination
K	0006974	biological_process	DNA damage response
K	0007283	biological_process	spermatogenesis
K	0016567	biological_process	protein ubiquitination
K	0016740	molecular_function	transferase activity
K	0019005	cellular_component	SCF ubiquitin ligase complex
K	0019788	molecular_function	NEDD8 transferase activity
K	0030163	biological_process	protein catabolic process
K	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
K	0031461	cellular_component	cullin-RING ubiquitin ligase complex
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
K	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
K	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
K	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0032480	biological_process	negative regulation of type I interferon production
K	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
K	0034644	biological_process	cellular response to UV
K	0042110	biological_process	T cell activation
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043687	biological_process	post-translational protein modification
K	0045116	biological_process	protein neddylation
K	0045732	biological_process	positive regulation of protein catabolic process
K	0046872	molecular_function	metal ion binding
K	0060090	molecular_function	molecular adaptor activity
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0061663	molecular_function	NEDD8 ligase activity
K	0062197	biological_process	cellular response to chemical stress
K	0070936	biological_process	protein K48-linked ubiquitination
K	0071230	biological_process	cellular response to amino acid stimulus
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0097602	molecular_function	cullin family protein binding
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	1900076	biological_process	regulation of cellular response to insulin stimulus
K	1902499	biological_process	positive regulation of protein autoubiquitination
K	1902883	biological_process	negative regulation of response to oxidative stress
K	1904263	biological_process	positive regulation of TORC1 signaling
L	0000165	biological_process	MAPK cascade
L	0000209	biological_process	protein polyubiquitination
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006974	biological_process	DNA damage response
L	0007283	biological_process	spermatogenesis
L	0016567	biological_process	protein ubiquitination
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019788	molecular_function	NEDD8 transferase activity
L	0030163	biological_process	protein catabolic process
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
L	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032480	biological_process	negative regulation of type I interferon production
L	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
L	0034644	biological_process	cellular response to UV
L	0042110	biological_process	T cell activation
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043687	biological_process	post-translational protein modification
L	0045116	biological_process	protein neddylation
L	0045732	biological_process	positive regulation of protein catabolic process
L	0046872	molecular_function	metal ion binding
L	0060090	molecular_function	molecular adaptor activity
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061663	molecular_function	NEDD8 ligase activity
L	0062197	biological_process	cellular response to chemical stress
L	0070936	biological_process	protein K48-linked ubiquitination
L	0071230	biological_process	cellular response to amino acid stimulus
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0097602	molecular_function	cullin family protein binding
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	1900076	biological_process	regulation of cellular response to insulin stimulus
L	1902499	biological_process	positive regulation of protein autoubiquitination
L	1902883	biological_process	negative regulation of response to oxidative stress
L	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgDSTSCIG

Chain	Residue	Details
A	PHE1237-GLY1246

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CnHgFCwrCL

Chain	Residue	Details
A	CYS2257-LEU2266

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. VLscIlhLLGQgYVkRrddrpqiLmYaA

Chain	Residue	Details
A	VAL1926-ALA1953

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	270
Details	ZN_FING: RING-type => ECO:0000255\|PROSITE-ProRule:PRU00175

Chain	Residue	Details
C	CYS53-ASN98
D	CYS53-ASN98
G	CYS53-ASN98
H	CYS53-ASN98
K	CYS53-ASN98
L	CYS53-ASN98

site_id	SWS_FT_FI2
Number of Residues	66
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DPL, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O

Chain	Residue	Details
C	CYS42
C	CYS94
C	ASP97
D	CYS42
D	CYS45
D	CYS53
D	CYS56
D	CYS68
D	CYS75
D	HIS77
D	HIS80
C	CYS45
D	HIS82
D	CYS94
D	ASP97
G	CYS42
G	CYS45
G	CYS53
G	CYS56
G	CYS68
G	CYS75
G	HIS77
C	CYS53
G	HIS80
G	HIS82
G	CYS94
G	ASP97
H	CYS42
H	CYS45
H	CYS53
H	CYS56
H	CYS68
H	CYS75
C	CYS56
H	HIS77
H	HIS80
H	HIS82
H	CYS94
H	ASP97
K	CYS42
K	CYS45
K	CYS53
K	CYS56
K	CYS68
C	CYS68
K	CYS75
K	HIS77
K	HIS80
K	HIS82
K	CYS94
K	ASP97
L	CYS42
L	CYS45
L	CYS53
L	CYS56
C	CYS75
L	CYS68
L	CYS75
L	HIS77
L	HIS80
L	HIS82
L	CYS94
L	ASP97
C	HIS77
C	HIS80
C	HIS82

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O

Chain	Residue	Details
C	CYS83
D	CYS83
G	CYS83
H	CYS83
K	CYS83
L	CYS83

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
C	MET1
D	MET1
G	MET1
H	MET1
K	MET1
L	MET1

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed => ECO:0000269\|Ref.8, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
C	ALA2
D	ALA2
G	ALA2
H	ALA2
K	ALA2
L	ALA2

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	THR9
A	CYS2166
I	HIS2090
I	CYS2093
I	CYS2096
I	CYS2115
I	CYS2120
I	CYS2160
I	CYS2166
I	CYS2181
I	CYS2184
I	CYS2189
A	CYS2181
I	CYS2192
I	HIS2198
I	CYS2203
I	CYS2236
I	CYS2239
I	CYS2254
I	CYS2257
I	CYS2262
I	CYS2265
I	HIS2273
A	CYS2184
I	CYS2279
J	CYS2070
J	CYS2073
J	CYS2088
J	HIS2090
J	CYS2093
J	CYS2096
J	CYS2115
J	CYS2120
J	CYS2160
A	CYS2189
J	CYS2166
J	CYS2181
J	CYS2184
J	CYS2189
J	CYS2192
J	HIS2198
J	CYS2203
J	CYS2236
J	CYS2239
J	CYS2254
A	CYS2192
J	CYS2257
J	CYS2262
J	CYS2265
J	HIS2273
J	CYS2279
A	HIS2198
A	CYS2203
A	CYS2236
A	CYS2239
A	CYS2254
D	THR9
A	CYS2257
A	CYS2262
A	CYS2265
A	HIS2273
A	CYS2279
B	CYS2070
B	CYS2073
B	CYS2088
B	HIS2090
B	CYS2093
G	THR9
B	CYS2096
B	CYS2115
B	CYS2120
B	CYS2160
B	CYS2166
B	CYS2181
B	CYS2184
B	CYS2189
B	CYS2192
B	HIS2198
H	THR9
B	CYS2203
B	CYS2236
B	CYS2239
B	CYS2254
B	CYS2257
B	CYS2262
B	CYS2265
B	HIS2273
B	CYS2279
E	CYS2070
K	THR9
E	CYS2073
E	CYS2088
E	HIS2090
E	CYS2093
E	CYS2096
E	CYS2115
E	CYS2120
E	CYS2160
E	CYS2166
E	CYS2181
L	THR9
E	CYS2184
E	CYS2189
E	CYS2192
E	HIS2198
E	CYS2203
E	CYS2236
E	CYS2239
E	CYS2254
E	CYS2257
E	CYS2262
A	CYS2115
E	CYS2265
E	HIS2273
E	CYS2279
F	CYS2070
F	CYS2073
F	CYS2088
F	HIS2090
F	CYS2093
F	CYS2096
F	CYS2115
A	CYS2120
F	CYS2120
F	CYS2160
F	CYS2166
F	CYS2181
F	CYS2184
F	CYS2189
F	CYS2192
F	HIS2198
F	CYS2203
F	CYS2236
A	CYS2160
F	CYS2239
F	CYS2254
F	CYS2257
F	CYS2262
F	CYS2265
F	HIS2273
F	CYS2279
I	CYS2070
I	CYS2073
I	CYS2088

site_id	SWS_FT_FI7
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER976
F	SER976
F	SER1457
F	SER2436
I	SER976
I	SER1457
I	SER2436
J	SER976
J	SER1457
J	SER2436
A	SER1457
A	SER2436
B	SER976
B	SER1457
B	SER2436
E	SER976
E	SER1457
E	SER2436

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)