8Q7E

Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007088	biological_process	regulation of mitotic nuclear division
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031461	cellular_component	cullin-RING ubiquitin ligase complex
A	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0046872	molecular_function	metal ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007088	biological_process	regulation of mitotic nuclear division
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0046872	molecular_function	metal ion binding
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000109	cellular_component	nucleotide-excision repair complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000165	biological_process	MAPK cascade
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006283	biological_process	transcription-coupled nucleotide-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006974	biological_process	DNA damage response
C	0007283	biological_process	spermatogenesis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0008270	molecular_function	zinc ion binding
C	0008283	biological_process	cell population proliferation
C	0010506	biological_process	regulation of autophagy
C	0010564	biological_process	regulation of cell cycle process
C	0010824	biological_process	regulation of centrosome duplication
C	0014033	biological_process	neural crest cell differentiation
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0019788	molecular_function	NEDD8 transferase activity
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0030510	biological_process	regulation of BMP signaling pathway
C	0030891	cellular_component	VCB complex
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031297	biological_process	replication fork processing
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032006	biological_process	regulation of TOR signaling
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032480	biological_process	negative regulation of type I interferon production
C	0032814	biological_process	regulation of natural killer cell activation
C	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0034644	biological_process	cellular response to UV
C	0040029	biological_process	epigenetic regulation of gene expression
C	0042110	biological_process	T cell activation
C	0042127	biological_process	regulation of cell population proliferation
C	0042752	biological_process	regulation of circadian rhythm
C	0042770	biological_process	signal transduction in response to DNA damage
C	0042981	biological_process	regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043687	biological_process	post-translational protein modification
C	0044314	biological_process	protein K27-linked ubiquitination
C	0044877	molecular_function	protein-containing complex binding
C	0045116	biological_process	protein neddylation
C	0045732	biological_process	positive regulation of protein catabolic process
C	0045995	biological_process	regulation of embryonic development
C	0046627	biological_process	negative regulation of insulin receptor signaling pathway
C	0046872	molecular_function	metal ion binding
C	0050727	biological_process	regulation of inflammatory response
C	0051298	biological_process	centrosome duplication
C	0051726	biological_process	regulation of cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0060173	biological_process	limb development
C	0060271	biological_process	cilium assembly
C	0060964	biological_process	regulation of miRNA-mediated gene silencing
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061663	molecular_function	NEDD8 ligase activity
C	0062197	biological_process	cellular response to chemical stress
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
C	0080135	biological_process	regulation of cellular response to stress
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0090734	cellular_component	site of DNA damage
C	0097602	molecular_function	cullin family protein binding
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	0160276	biological_process	negative regulation of beige fat cell differentiation
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1901524	biological_process	regulation of mitophagy
C	1901525	biological_process	negative regulation of mitophagy
C	1901987	biological_process	regulation of cell cycle phase transition
C	1902412	biological_process	regulation of mitotic cytokinesis
C	1902499	biological_process	positive regulation of protein autoubiquitination
C	1902883	biological_process	negative regulation of response to oxidative stress
C	1904178	biological_process	negative regulation of adipose tissue development
C	1904263	biological_process	positive regulation of TORC1 signaling
C	1904415	biological_process	regulation of xenophagy
C	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
C	2000001	biological_process	regulation of DNA damage checkpoint
C	2000036	biological_process	regulation of stem cell population maintenance
C	2000104	biological_process	negative regulation of DNA-templated DNA replication
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000109	cellular_component	nucleotide-excision repair complex
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008270	molecular_function	zinc ion binding
D	0008283	biological_process	cell population proliferation
D	0010506	biological_process	regulation of autophagy
D	0010564	biological_process	regulation of cell cycle process
D	0010824	biological_process	regulation of centrosome duplication
D	0014033	biological_process	neural crest cell differentiation
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019788	molecular_function	NEDD8 transferase activity
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0030510	biological_process	regulation of BMP signaling pathway
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031297	biological_process	replication fork processing
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032006	biological_process	regulation of TOR signaling
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0032814	biological_process	regulation of natural killer cell activation
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0040029	biological_process	epigenetic regulation of gene expression
D	0042110	biological_process	T cell activation
D	0042127	biological_process	regulation of cell population proliferation
D	0042752	biological_process	regulation of circadian rhythm
D	0042770	biological_process	signal transduction in response to DNA damage
D	0042981	biological_process	regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044314	biological_process	protein K27-linked ubiquitination
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045995	biological_process	regulation of embryonic development
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0050727	biological_process	regulation of inflammatory response
D	0051298	biological_process	centrosome duplication
D	0051726	biological_process	regulation of cell cycle
D	0060090	molecular_function	molecular adaptor activity
D	0060173	biological_process	limb development
D	0060271	biological_process	cilium assembly
D	0060964	biological_process	regulation of miRNA-mediated gene silencing
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0080135	biological_process	regulation of cellular response to stress
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0160276	biological_process	negative regulation of beige fat cell differentiation
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901524	biological_process	regulation of mitophagy
D	1901525	biological_process	negative regulation of mitophagy
D	1901987	biological_process	regulation of cell cycle phase transition
D	1902412	biological_process	regulation of mitotic cytokinesis
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904178	biological_process	negative regulation of adipose tissue development
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1904415	biological_process	regulation of xenophagy
D	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
D	2000001	biological_process	regulation of DNA damage checkpoint
D	2000036	biological_process	regulation of stem cell population maintenance
D	2000104	biological_process	negative regulation of DNA-templated DNA replication
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0007088	biological_process	regulation of mitotic nuclear division
E	0008270	molecular_function	zinc ion binding
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0046872	molecular_function	metal ion binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0007088	biological_process	regulation of mitotic nuclear division
F	0008270	molecular_function	zinc ion binding
F	0016567	biological_process	protein ubiquitination
F	0016740	molecular_function	transferase activity
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0046872	molecular_function	metal ion binding
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
G	0000082	biological_process	G1/S transition of mitotic cell cycle
G	0000109	cellular_component	nucleotide-excision repair complex
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000165	biological_process	MAPK cascade
G	0000209	biological_process	protein polyubiquitination
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005794	cellular_component	Golgi apparatus
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006283	biological_process	transcription-coupled nucleotide-excision repair
G	0006289	biological_process	nucleotide-excision repair
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006513	biological_process	protein monoubiquitination
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006974	biological_process	DNA damage response
G	0007283	biological_process	spermatogenesis
G	0007346	biological_process	regulation of mitotic cell cycle
G	0008270	molecular_function	zinc ion binding
G	0008283	biological_process	cell population proliferation
G	0010506	biological_process	regulation of autophagy
G	0010564	biological_process	regulation of cell cycle process
G	0010824	biological_process	regulation of centrosome duplication
G	0014033	biological_process	neural crest cell differentiation
G	0016567	biological_process	protein ubiquitination
G	0016740	molecular_function	transferase activity
G	0019005	cellular_component	SCF ubiquitin ligase complex
G	0019788	molecular_function	NEDD8 transferase activity
G	0030174	biological_process	regulation of DNA-templated DNA replication initiation
G	0030510	biological_process	regulation of BMP signaling pathway
G	0030891	cellular_component	VCB complex
G	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
G	0031297	biological_process	replication fork processing
G	0031461	cellular_component	cullin-RING ubiquitin ligase complex
G	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
G	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
G	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
G	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
G	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
G	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032006	biological_process	regulation of TOR signaling
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0032480	biological_process	negative regulation of type I interferon production
G	0032814	biological_process	regulation of natural killer cell activation
G	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
G	0034599	biological_process	cellular response to oxidative stress
G	0034644	biological_process	cellular response to UV
G	0040029	biological_process	epigenetic regulation of gene expression
G	0042110	biological_process	T cell activation
G	0042127	biological_process	regulation of cell population proliferation
G	0042752	biological_process	regulation of circadian rhythm
G	0042770	biological_process	signal transduction in response to DNA damage
G	0042981	biological_process	regulation of apoptotic process
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043687	biological_process	post-translational protein modification
G	0044314	biological_process	protein K27-linked ubiquitination
G	0044877	molecular_function	protein-containing complex binding
G	0045116	biological_process	protein neddylation
G	0045732	biological_process	positive regulation of protein catabolic process
G	0045995	biological_process	regulation of embryonic development
G	0046627	biological_process	negative regulation of insulin receptor signaling pathway
G	0046872	molecular_function	metal ion binding
G	0050727	biological_process	regulation of inflammatory response
G	0051298	biological_process	centrosome duplication
G	0051726	biological_process	regulation of cell cycle
G	0060090	molecular_function	molecular adaptor activity
G	0060173	biological_process	limb development
G	0060271	biological_process	cilium assembly
G	0060964	biological_process	regulation of miRNA-mediated gene silencing
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0061663	molecular_function	NEDD8 ligase activity
G	0062197	biological_process	cellular response to chemical stress
G	0070936	biological_process	protein K48-linked ubiquitination
G	0071230	biological_process	cellular response to amino acid stimulus
G	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
G	0080135	biological_process	regulation of cellular response to stress
G	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
G	0090734	cellular_component	site of DNA damage
G	0097602	molecular_function	cullin family protein binding
G	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
G	0160240	biological_process	RNA polymerase II transcription initiation surveillance
G	0160276	biological_process	negative regulation of beige fat cell differentiation
G	1900076	biological_process	regulation of cellular response to insulin stimulus
G	1901524	biological_process	regulation of mitophagy
G	1901525	biological_process	negative regulation of mitophagy
G	1901987	biological_process	regulation of cell cycle phase transition
G	1902412	biological_process	regulation of mitotic cytokinesis
G	1902499	biological_process	positive regulation of protein autoubiquitination
G	1902883	biological_process	negative regulation of response to oxidative stress
G	1904178	biological_process	negative regulation of adipose tissue development
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1904415	biological_process	regulation of xenophagy
G	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
G	2000001	biological_process	regulation of DNA damage checkpoint
G	2000036	biological_process	regulation of stem cell population maintenance
G	2000104	biological_process	negative regulation of DNA-templated DNA replication
H	0000082	biological_process	G1/S transition of mitotic cell cycle
H	0000109	cellular_component	nucleotide-excision repair complex
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000165	biological_process	MAPK cascade
H	0000209	biological_process	protein polyubiquitination
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0006281	biological_process	DNA repair
H	0006283	biological_process	transcription-coupled nucleotide-excision repair
H	0006289	biological_process	nucleotide-excision repair
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006974	biological_process	DNA damage response
H	0007283	biological_process	spermatogenesis
H	0007346	biological_process	regulation of mitotic cell cycle
H	0008270	molecular_function	zinc ion binding
H	0008283	biological_process	cell population proliferation
H	0010506	biological_process	regulation of autophagy
H	0010564	biological_process	regulation of cell cycle process
H	0010824	biological_process	regulation of centrosome duplication
H	0014033	biological_process	neural crest cell differentiation
H	0016567	biological_process	protein ubiquitination
H	0016740	molecular_function	transferase activity
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019788	molecular_function	NEDD8 transferase activity
H	0030174	biological_process	regulation of DNA-templated DNA replication initiation
H	0030510	biological_process	regulation of BMP signaling pathway
H	0030891	cellular_component	VCB complex
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031297	biological_process	replication fork processing
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
H	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032006	biological_process	regulation of TOR signaling
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0032480	biological_process	negative regulation of type I interferon production
H	0032814	biological_process	regulation of natural killer cell activation
H	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
H	0034599	biological_process	cellular response to oxidative stress
H	0034644	biological_process	cellular response to UV
H	0040029	biological_process	epigenetic regulation of gene expression
H	0042110	biological_process	T cell activation
H	0042127	biological_process	regulation of cell population proliferation
H	0042752	biological_process	regulation of circadian rhythm
H	0042770	biological_process	signal transduction in response to DNA damage
H	0042981	biological_process	regulation of apoptotic process
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043687	biological_process	post-translational protein modification
H	0044314	biological_process	protein K27-linked ubiquitination
H	0044877	molecular_function	protein-containing complex binding
H	0045116	biological_process	protein neddylation
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045995	biological_process	regulation of embryonic development
H	0046627	biological_process	negative regulation of insulin receptor signaling pathway
H	0046872	molecular_function	metal ion binding
H	0050727	biological_process	regulation of inflammatory response
H	0051298	biological_process	centrosome duplication
H	0051726	biological_process	regulation of cell cycle
H	0060090	molecular_function	molecular adaptor activity
H	0060173	biological_process	limb development
H	0060271	biological_process	cilium assembly
H	0060964	biological_process	regulation of miRNA-mediated gene silencing
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0061663	molecular_function	NEDD8 ligase activity
H	0062197	biological_process	cellular response to chemical stress
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071230	biological_process	cellular response to amino acid stimulus
H	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
H	0080135	biological_process	regulation of cellular response to stress
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090734	cellular_component	site of DNA damage
H	0097602	molecular_function	cullin family protein binding
H	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
H	0160240	biological_process	RNA polymerase II transcription initiation surveillance
H	0160276	biological_process	negative regulation of beige fat cell differentiation
H	1900076	biological_process	regulation of cellular response to insulin stimulus
H	1901524	biological_process	regulation of mitophagy
H	1901525	biological_process	negative regulation of mitophagy
H	1901987	biological_process	regulation of cell cycle phase transition
H	1902412	biological_process	regulation of mitotic cytokinesis
H	1902499	biological_process	positive regulation of protein autoubiquitination
H	1902883	biological_process	negative regulation of response to oxidative stress
H	1904178	biological_process	negative regulation of adipose tissue development
H	1904263	biological_process	positive regulation of TORC1 signaling
H	1904415	biological_process	regulation of xenophagy
H	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
H	2000001	biological_process	regulation of DNA damage checkpoint
H	2000036	biological_process	regulation of stem cell population maintenance
H	2000104	biological_process	negative regulation of DNA-templated DNA replication
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0007088	biological_process	regulation of mitotic nuclear division
I	0008270	molecular_function	zinc ion binding
I	0016567	biological_process	protein ubiquitination
I	0016740	molecular_function	transferase activity
I	0031461	cellular_component	cullin-RING ubiquitin ligase complex
I	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0046872	molecular_function	metal ion binding
I	0061630	molecular_function	ubiquitin protein ligase activity
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0007088	biological_process	regulation of mitotic nuclear division
J	0008270	molecular_function	zinc ion binding
J	0016567	biological_process	protein ubiquitination
J	0016740	molecular_function	transferase activity
J	0031461	cellular_component	cullin-RING ubiquitin ligase complex
J	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0046872	molecular_function	metal ion binding
J	0061630	molecular_function	ubiquitin protein ligase activity
J	0160072	molecular_function	ubiquitin ligase complex scaffold activity
K	0000082	biological_process	G1/S transition of mitotic cell cycle
K	0000109	cellular_component	nucleotide-excision repair complex
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000165	biological_process	MAPK cascade
K	0000209	biological_process	protein polyubiquitination
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005794	cellular_component	Golgi apparatus
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006283	biological_process	transcription-coupled nucleotide-excision repair
K	0006289	biological_process	nucleotide-excision repair
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006513	biological_process	protein monoubiquitination
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006974	biological_process	DNA damage response
K	0007283	biological_process	spermatogenesis
K	0007346	biological_process	regulation of mitotic cell cycle
K	0008270	molecular_function	zinc ion binding
K	0008283	biological_process	cell population proliferation
K	0010506	biological_process	regulation of autophagy
K	0010564	biological_process	regulation of cell cycle process
K	0010824	biological_process	regulation of centrosome duplication
K	0014033	biological_process	neural crest cell differentiation
K	0016567	biological_process	protein ubiquitination
K	0016740	molecular_function	transferase activity
K	0019005	cellular_component	SCF ubiquitin ligase complex
K	0019788	molecular_function	NEDD8 transferase activity
K	0030174	biological_process	regulation of DNA-templated DNA replication initiation
K	0030510	biological_process	regulation of BMP signaling pathway
K	0030891	cellular_component	VCB complex
K	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
K	0031297	biological_process	replication fork processing
K	0031461	cellular_component	cullin-RING ubiquitin ligase complex
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
K	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
K	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
K	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032006	biological_process	regulation of TOR signaling
K	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0032480	biological_process	negative regulation of type I interferon production
K	0032814	biological_process	regulation of natural killer cell activation
K	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
K	0034599	biological_process	cellular response to oxidative stress
K	0034644	biological_process	cellular response to UV
K	0040029	biological_process	epigenetic regulation of gene expression
K	0042110	biological_process	T cell activation
K	0042127	biological_process	regulation of cell population proliferation
K	0042752	biological_process	regulation of circadian rhythm
K	0042770	biological_process	signal transduction in response to DNA damage
K	0042981	biological_process	regulation of apoptotic process
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043687	biological_process	post-translational protein modification
K	0044314	biological_process	protein K27-linked ubiquitination
K	0044877	molecular_function	protein-containing complex binding
K	0045116	biological_process	protein neddylation
K	0045732	biological_process	positive regulation of protein catabolic process
K	0045995	biological_process	regulation of embryonic development
K	0046627	biological_process	negative regulation of insulin receptor signaling pathway
K	0046872	molecular_function	metal ion binding
K	0050727	biological_process	regulation of inflammatory response
K	0051298	biological_process	centrosome duplication
K	0051726	biological_process	regulation of cell cycle
K	0060090	molecular_function	molecular adaptor activity
K	0060173	biological_process	limb development
K	0060271	biological_process	cilium assembly
K	0060964	biological_process	regulation of miRNA-mediated gene silencing
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0061663	molecular_function	NEDD8 ligase activity
K	0062197	biological_process	cellular response to chemical stress
K	0070936	biological_process	protein K48-linked ubiquitination
K	0071230	biological_process	cellular response to amino acid stimulus
K	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
K	0080135	biological_process	regulation of cellular response to stress
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0090734	cellular_component	site of DNA damage
K	0097602	molecular_function	cullin family protein binding
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	0160240	biological_process	RNA polymerase II transcription initiation surveillance
K	0160276	biological_process	negative regulation of beige fat cell differentiation
K	1900076	biological_process	regulation of cellular response to insulin stimulus
K	1901524	biological_process	regulation of mitophagy
K	1901525	biological_process	negative regulation of mitophagy
K	1901987	biological_process	regulation of cell cycle phase transition
K	1902412	biological_process	regulation of mitotic cytokinesis
K	1902499	biological_process	positive regulation of protein autoubiquitination
K	1902883	biological_process	negative regulation of response to oxidative stress
K	1904178	biological_process	negative regulation of adipose tissue development
K	1904263	biological_process	positive regulation of TORC1 signaling
K	1904415	biological_process	regulation of xenophagy
K	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
K	2000001	biological_process	regulation of DNA damage checkpoint
K	2000036	biological_process	regulation of stem cell population maintenance
K	2000104	biological_process	negative regulation of DNA-templated DNA replication
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000109	cellular_component	nucleotide-excision repair complex
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000165	biological_process	MAPK cascade
L	0000209	biological_process	protein polyubiquitination
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005794	cellular_component	Golgi apparatus
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006283	biological_process	transcription-coupled nucleotide-excision repair
L	0006289	biological_process	nucleotide-excision repair
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006974	biological_process	DNA damage response
L	0007283	biological_process	spermatogenesis
L	0007346	biological_process	regulation of mitotic cell cycle
L	0008270	molecular_function	zinc ion binding
L	0008283	biological_process	cell population proliferation
L	0010506	biological_process	regulation of autophagy
L	0010564	biological_process	regulation of cell cycle process
L	0010824	biological_process	regulation of centrosome duplication
L	0014033	biological_process	neural crest cell differentiation
L	0016567	biological_process	protein ubiquitination
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019788	molecular_function	NEDD8 transferase activity
L	0030174	biological_process	regulation of DNA-templated DNA replication initiation
L	0030510	biological_process	regulation of BMP signaling pathway
L	0030891	cellular_component	VCB complex
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031297	biological_process	replication fork processing
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
L	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032006	biological_process	regulation of TOR signaling
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032480	biological_process	negative regulation of type I interferon production
L	0032814	biological_process	regulation of natural killer cell activation
L	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
L	0034599	biological_process	cellular response to oxidative stress
L	0034644	biological_process	cellular response to UV
L	0040029	biological_process	epigenetic regulation of gene expression
L	0042110	biological_process	T cell activation
L	0042127	biological_process	regulation of cell population proliferation
L	0042752	biological_process	regulation of circadian rhythm
L	0042770	biological_process	signal transduction in response to DNA damage
L	0042981	biological_process	regulation of apoptotic process
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043687	biological_process	post-translational protein modification
L	0044314	biological_process	protein K27-linked ubiquitination
L	0044877	molecular_function	protein-containing complex binding
L	0045116	biological_process	protein neddylation
L	0045732	biological_process	positive regulation of protein catabolic process
L	0045995	biological_process	regulation of embryonic development
L	0046627	biological_process	negative regulation of insulin receptor signaling pathway
L	0046872	molecular_function	metal ion binding
L	0050727	biological_process	regulation of inflammatory response
L	0051298	biological_process	centrosome duplication
L	0051726	biological_process	regulation of cell cycle
L	0060090	molecular_function	molecular adaptor activity
L	0060173	biological_process	limb development
L	0060271	biological_process	cilium assembly
L	0060964	biological_process	regulation of miRNA-mediated gene silencing
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061663	molecular_function	NEDD8 ligase activity
L	0062197	biological_process	cellular response to chemical stress
L	0070936	biological_process	protein K48-linked ubiquitination
L	0071230	biological_process	cellular response to amino acid stimulus
L	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
L	0080135	biological_process	regulation of cellular response to stress
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090734	cellular_component	site of DNA damage
L	0097602	molecular_function	cullin family protein binding
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	0160240	biological_process	RNA polymerase II transcription initiation surveillance
L	0160276	biological_process	negative regulation of beige fat cell differentiation
L	1900076	biological_process	regulation of cellular response to insulin stimulus
L	1901524	biological_process	regulation of mitophagy
L	1901525	biological_process	negative regulation of mitophagy
L	1901987	biological_process	regulation of cell cycle phase transition
L	1902412	biological_process	regulation of mitotic cytokinesis
L	1902499	biological_process	positive regulation of protein autoubiquitination
L	1902883	biological_process	negative regulation of response to oxidative stress
L	1904178	biological_process	negative regulation of adipose tissue development
L	1904263	biological_process	positive regulation of TORC1 signaling
L	1904415	biological_process	regulation of xenophagy
L	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
L	2000001	biological_process	regulation of DNA damage checkpoint
L	2000036	biological_process	regulation of stem cell population maintenance
L	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgDSTSCIG

Chain	Residue	Details
A	PHE1237-GLY1246

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CnHgFCwrCL

Chain	Residue	Details
A	CYS2257-LEU2266

---

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. VLscIlhLLGQgYVkRrddrpqiLmYaA

Chain	Residue	Details
A	VAL1926-ALA1953

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---