8Q75

Copper-transporting ATPase HMA4 in E2P state with AlF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005507	molecular_function	copper ion binding
A	0005524	molecular_function	ATP binding
A	0005773	cellular_component	vacuole
A	0005774	cellular_component	vacuolar membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0010273	biological_process	detoxification of copper ion
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0035434	biological_process	copper ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0140581	molecular_function	P-type monovalent copper transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP641-THR647

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site_id	PS01047
Number of Residues	30
Details	HMA_1 Heavy-metal-associated domain. IkGMaCtSCsesVEraLqmvpgvkkaa.VgL

Chain	Residue	Details
A	ILE117-LEU146

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PHE280-ILE300
A	MET315-TRP335
A	MET352-LEU372
A	PHE385-VAL405
A	PHE545-GLY565
A	LEU584-ALA604
A	VAL907-PHE927
A	TRP935-LEU955

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00280

Chain	Residue	Details
A	CYS122
A	CYS125

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