8Q6P

X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000228	cellular_component	nuclear chromosome
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0000785	cellular_component	chromatin
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003682	molecular_function	chromatin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005694	cellular_component	chromosome
2	0006260	biological_process	DNA replication
2	0006261	biological_process	DNA-templated DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006279	biological_process	premeiotic DNA replication
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0030174	biological_process	regulation of DNA-templated DNA replication initiation
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0044786	biological_process	cell cycle DNA replication
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000785	cellular_component	chromatin
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005694	cellular_component	chromosome
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030174	biological_process	regulation of DNA-templated DNA replication initiation
3	0042555	cellular_component	MCM complex
3	0044786	biological_process	cell cycle DNA replication
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0000785	cellular_component	chromatin
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003682	molecular_function	chromatin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005694	cellular_component	chromosome
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0030174	biological_process	regulation of DNA-templated DNA replication initiation
4	0042555	cellular_component	MCM complex
4	0044786	biological_process	cell cycle DNA replication
4	0046872	molecular_function	metal ion binding
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000785	cellular_component	chromatin
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003682	molecular_function	chromatin binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005694	cellular_component	chromosome
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0044786	biological_process	cell cycle DNA replication
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0000785	cellular_component	chromatin
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003682	molecular_function	chromatin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005694	cellular_component	chromosome
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0008270	molecular_function	zinc ion binding
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0030174	biological_process	regulation of DNA-templated DNA replication initiation
6	0042555	cellular_component	MCM complex
6	0044786	biological_process	cell cycle DNA replication
6	0046872	molecular_function	metal ion binding
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000785	cellular_component	chromatin
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005694	cellular_component	chromosome
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0008270	molecular_function	zinc ion binding
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030174	biological_process	regulation of DNA-templated DNA replication initiation
7	0042555	cellular_component	MCM complex
7	0046872	molecular_function	metal ion binding
7	0071162	cellular_component	CMG complex
L	0000077	biological_process	DNA damage checkpoint signaling
L	0005634	cellular_component	nucleus
L	0005657	cellular_component	replication fork
L	0006260	biological_process	DNA replication
L	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
L	0030894	cellular_component	replisome
L	0031297	biological_process	replication fork processing
L	0033260	biological_process	nuclear DNA replication
L	0033314	biological_process	mitotic DNA replication checkpoint signaling
L	0051301	biological_process	cell division

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCCIDEFD

Chain	Residue	Details
6	GLY457-ASP465
3	GLY404-ASP412
4	GLY569-ASP577
7	GLY439-ASP447
2	GLY567-ASP575
5	GLY441-ASP449

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	414
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P49736","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33991","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33992","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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