8Q6O

X. laevis CMG dimer bound to dimeric DONSON - without ATPase

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000228	cellular_component	nuclear chromosome
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0000785	cellular_component	chromatin
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003682	molecular_function	chromatin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005694	cellular_component	chromosome
2	0006260	biological_process	DNA replication
2	0006261	biological_process	DNA-templated DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006279	biological_process	premeiotic DNA replication
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0030174	biological_process	regulation of DNA-templated DNA replication initiation
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0044786	biological_process	cell cycle DNA replication
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000785	cellular_component	chromatin
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005694	cellular_component	chromosome
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030174	biological_process	regulation of DNA-templated DNA replication initiation
3	0042555	cellular_component	MCM complex
3	0044786	biological_process	cell cycle DNA replication
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0000785	cellular_component	chromatin
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003682	molecular_function	chromatin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005694	cellular_component	chromosome
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0030174	biological_process	regulation of DNA-templated DNA replication initiation
4	0042555	cellular_component	MCM complex
4	0044786	biological_process	cell cycle DNA replication
4	0046872	molecular_function	metal ion binding
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000785	cellular_component	chromatin
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003682	molecular_function	chromatin binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005694	cellular_component	chromosome
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0044786	biological_process	cell cycle DNA replication
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0000785	cellular_component	chromatin
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003682	molecular_function	chromatin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005694	cellular_component	chromosome
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0008270	molecular_function	zinc ion binding
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0030174	biological_process	regulation of DNA-templated DNA replication initiation
6	0042555	cellular_component	MCM complex
6	0044786	biological_process	cell cycle DNA replication
6	0046872	molecular_function	metal ion binding
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000785	cellular_component	chromatin
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005694	cellular_component	chromosome
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0008270	molecular_function	zinc ion binding
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030174	biological_process	regulation of DNA-templated DNA replication initiation
7	0042555	cellular_component	MCM complex
7	0046872	molecular_function	metal ion binding
7	0071162	cellular_component	CMG complex
A	0000166	molecular_function	nucleotide binding
A	0000228	cellular_component	nuclear chromosome
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003682	molecular_function	chromatin binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006270	biological_process	DNA replication initiation
A	0006279	biological_process	premeiotic DNA replication
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0042555	cellular_component	MCM complex
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0044786	biological_process	cell cycle DNA replication
A	0046872	molecular_function	metal ion binding
A	0071162	cellular_component	CMG complex
A	1902975	biological_process	mitotic DNA replication initiation
B	0000166	molecular_function	nucleotide binding
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003682	molecular_function	chromatin binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006260	biological_process	DNA replication
B	0006270	biological_process	DNA replication initiation
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006279	biological_process	premeiotic DNA replication
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017116	molecular_function	single-stranded DNA helicase activity
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0042555	cellular_component	MCM complex
B	0044786	biological_process	cell cycle DNA replication
B	0071162	cellular_component	CMG complex
B	1902975	biological_process	mitotic DNA replication initiation
C	0000166	molecular_function	nucleotide binding
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003682	molecular_function	chromatin binding
C	0003697	molecular_function	single-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006270	biological_process	DNA replication initiation
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006279	biological_process	premeiotic DNA replication
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017116	molecular_function	single-stranded DNA helicase activity
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0042555	cellular_component	MCM complex
C	0044786	biological_process	cell cycle DNA replication
C	0046872	molecular_function	metal ion binding
C	0071162	cellular_component	CMG complex
C	1902975	biological_process	mitotic DNA replication initiation
D	0000166	molecular_function	nucleotide binding
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0003682	molecular_function	chromatin binding
D	0003688	molecular_function	DNA replication origin binding
D	0003697	molecular_function	single-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0006279	biological_process	premeiotic DNA replication
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017116	molecular_function	single-stranded DNA helicase activity
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0042555	cellular_component	MCM complex
D	0043138	molecular_function	3'-5' DNA helicase activity
D	0044786	biological_process	cell cycle DNA replication
D	0071162	cellular_component	CMG complex
E	0000166	molecular_function	nucleotide binding
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000785	cellular_component	chromatin
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003682	molecular_function	chromatin binding
E	0003697	molecular_function	single-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017116	molecular_function	single-stranded DNA helicase activity
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0042555	cellular_component	MCM complex
E	0044786	biological_process	cell cycle DNA replication
E	0046872	molecular_function	metal ion binding
E	0071162	cellular_component	CMG complex
E	1902969	biological_process	mitotic DNA replication
E	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
F	0000166	molecular_function	nucleotide binding
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003682	molecular_function	chromatin binding
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006260	biological_process	DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006271	biological_process	DNA strand elongation involved in DNA replication
F	0008270	molecular_function	zinc ion binding
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017116	molecular_function	single-stranded DNA helicase activity
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0042555	cellular_component	MCM complex
F	0046872	molecular_function	metal ion binding
F	0071162	cellular_component	CMG complex
G	0000811	cellular_component	GINS complex
G	0003682	molecular_function	chromatin binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006260	biological_process	DNA replication
G	0071162	cellular_component	CMG complex
G	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
H	0000727	biological_process	double-strand break repair via break-induced replication
H	0000811	cellular_component	GINS complex
H	0003682	molecular_function	chromatin binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0006260	biological_process	DNA replication
H	0006271	biological_process	DNA strand elongation involved in DNA replication
H	0032784	biological_process	regulation of DNA-templated transcription elongation
H	0071162	cellular_component	CMG complex
I	0000811	cellular_component	GINS complex
I	0003682	molecular_function	chromatin binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0006260	biological_process	DNA replication
I	0006270	biological_process	DNA replication initiation
I	0071162	cellular_component	CMG complex
I	1902975	biological_process	mitotic DNA replication initiation
J	0000727	biological_process	double-strand break repair via break-induced replication
J	0003682	molecular_function	chromatin binding
J	0003688	molecular_function	DNA replication origin binding
J	0003697	molecular_function	single-stranded DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0006260	biological_process	DNA replication
J	0006270	biological_process	DNA replication initiation
J	0031261	cellular_component	DNA replication preinitiation complex
J	0071162	cellular_component	CMG complex
J	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
K	0000727	biological_process	double-strand break repair via break-induced replication
K	0000811	cellular_component	GINS complex
K	0003682	molecular_function	chromatin binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0006260	biological_process	DNA replication
K	0006261	biological_process	DNA-templated DNA replication
K	0071162	cellular_component	CMG complex
L	0000077	biological_process	DNA damage checkpoint signaling
L	0005634	cellular_component	nucleus
L	0005657	cellular_component	replication fork
L	0006260	biological_process	DNA replication
L	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
L	0030894	cellular_component	replisome
L	0031297	biological_process	replication fork processing
L	0033260	biological_process	nuclear DNA replication
L	0033314	biological_process	mitotic DNA replication checkpoint signaling
L	0051301	biological_process	cell division
M	0000811	cellular_component	GINS complex
M	0003682	molecular_function	chromatin binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0006260	biological_process	DNA replication
M	0071162	cellular_component	CMG complex
M	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
N	0000727	biological_process	double-strand break repair via break-induced replication
N	0000811	cellular_component	GINS complex
N	0003682	molecular_function	chromatin binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0006260	biological_process	DNA replication
N	0006271	biological_process	DNA strand elongation involved in DNA replication
N	0032784	biological_process	regulation of DNA-templated transcription elongation
N	0071162	cellular_component	CMG complex
O	0000811	cellular_component	GINS complex
O	0003682	molecular_function	chromatin binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0006260	biological_process	DNA replication
O	0006270	biological_process	DNA replication initiation
O	0071162	cellular_component	CMG complex
O	1902975	biological_process	mitotic DNA replication initiation
P	0000727	biological_process	double-strand break repair via break-induced replication
P	0003682	molecular_function	chromatin binding
P	0003688	molecular_function	DNA replication origin binding
P	0003697	molecular_function	single-stranded DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0006260	biological_process	DNA replication
P	0006270	biological_process	DNA replication initiation
P	0031261	cellular_component	DNA replication preinitiation complex
P	0071162	cellular_component	CMG complex
P	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
Q	0000727	biological_process	double-strand break repair via break-induced replication
Q	0000811	cellular_component	GINS complex
Q	0003682	molecular_function	chromatin binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0005737	cellular_component	cytoplasm
Q	0006260	biological_process	DNA replication
Q	0006261	biological_process	DNA-templated DNA replication
Q	0071162	cellular_component	CMG complex
R	0000077	biological_process	DNA damage checkpoint signaling
R	0005634	cellular_component	nucleus
R	0005657	cellular_component	replication fork
R	0006260	biological_process	DNA replication
R	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
R	0030894	cellular_component	replisome
R	0031297	biological_process	replication fork processing
R	0033260	biological_process	nuclear DNA replication
R	0033314	biological_process	mitotic DNA replication checkpoint signaling
R	0051301	biological_process	cell division

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCCIDEFD

Chain	Residue	Details
E	GLY457-ASP465
B	GLY404-ASP412
C	GLY569-ASP577
F	GLY439-ASP447
A	GLY567-ASP575
D	GLY441-ASP449

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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