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8Q5H

Human KMN network (outer kinetochore)

Functional Information from GO Data
ChainGOidnamespacecontents
50007059biological_processchromosome segregation
50031262cellular_componentNdc80 complex
A0000070biological_processmitotic sister chromatid segregation
A0000278biological_processmitotic cell cycle
A0000444cellular_componentMIS12/MIND type complex
A0000775cellular_componentchromosome, centromeric region
A0000776cellular_componentkinetochore
A0000922cellular_componentspindle pole
A0000940cellular_componentouter kinetochore
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0007059biological_processchromosome segregation
A0008608biological_processattachment of spindle microtubules to kinetochore
A0051301biological_processcell division
A0051315biological_processattachment of mitotic spindle microtubules to kinetochore
A0051382biological_processkinetochore assembly
B0000444cellular_componentMIS12/MIND type complex
B0000775cellular_componentchromosome, centromeric region
B0000776cellular_componentkinetochore
B0000922cellular_componentspindle pole
B0000940cellular_componentouter kinetochore
B0003713molecular_functiontranscription coactivator activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005667cellular_componenttranscription regulator complex
B0005694cellular_componentchromosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006366biological_processtranscription by RNA polymerase II
B0007059biological_processchromosome segregation
B0008608biological_processattachment of spindle microtubules to kinetochore
B0043231cellular_componentintracellular membrane-bounded organelle
B0043522molecular_functionleucine zipper domain binding
B0045893biological_processpositive regulation of DNA-templated transcription
B0051301biological_processcell division
D0000444cellular_componentMIS12/MIND type complex
D0000775cellular_componentchromosome, centromeric region
D0000776cellular_componentkinetochore
D0000922cellular_componentspindle pole
D0000940cellular_componentouter kinetochore
D0001650cellular_componentfibrillar center
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005730cellular_componentnucleolus
D0005829cellular_componentcytosol
D0007059biological_processchromosome segregation
D0008608biological_processattachment of spindle microtubules to kinetochore
D0014841biological_processskeletal muscle satellite cell proliferation
D0016604cellular_componentnuclear body
D0035578cellular_componentazurophil granule lumen
D0051301biological_processcell division
K0008608biological_processattachment of spindle microtubules to kinetochore
K0034501biological_processprotein localization to kinetochore
N0000070biological_processmitotic sister chromatid segregation
N0000444cellular_componentMIS12/MIND type complex
N0000775cellular_componentchromosome, centromeric region
N0000776cellular_componentkinetochore
N0000922cellular_componentspindle pole
N0000940cellular_componentouter kinetochore
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005694cellular_componentchromosome
N0005829cellular_componentcytosol
N0007059biological_processchromosome segregation
N0008608biological_processattachment of spindle microtubules to kinetochore
N0016607cellular_componentnuclear speck
N0051301biological_processcell division
Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. VVLDPPW
ChainResidueDetails
NVAL8-TRP14

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
NSER4

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
NTHR244

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
DSER58

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER77

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER81

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER109
DSER125
DSER331

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS253

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PDB entries from 2024-07-17

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