8Q4G

Thin filament from FIB milled relaxed left ventricular mouse myofibrils

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0007015	biological_process	actin filament organization
A	0009410	biological_process	response to xenobiotic stimulus
A	0010628	biological_process	positive regulation of gene expression
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0017022	molecular_function	myosin binding
A	0030017	cellular_component	sarcomere
A	0030027	cellular_component	lamellipodium
A	0030048	biological_process	actin filament-based movement
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031032	biological_process	actomyosin structure organization
A	0031674	cellular_component	I band
A	0033275	biological_process	actin-myosin filament sliding
A	0043066	biological_process	negative regulation of apoptotic process
A	0044297	cellular_component	cell body
A	0045202	cellular_component	synapse
A	0045471	biological_process	response to ethanol
A	0055003	biological_process	cardiac myofibril assembly
A	0055008	biological_process	cardiac muscle tissue morphogenesis
A	0060047	biological_process	heart contraction
A	0060048	biological_process	cardiac muscle contraction
A	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
A	0090131	biological_process	mesenchyme migration
A	0098978	cellular_component	glutamatergic synapse
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0007015	biological_process	actin filament organization
B	0009410	biological_process	response to xenobiotic stimulus
B	0010628	biological_process	positive regulation of gene expression
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0017022	molecular_function	myosin binding
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030048	biological_process	actin filament-based movement
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031032	biological_process	actomyosin structure organization
B	0031674	cellular_component	I band
B	0033275	biological_process	actin-myosin filament sliding
B	0043066	biological_process	negative regulation of apoptotic process
B	0044297	cellular_component	cell body
B	0045202	cellular_component	synapse
B	0045471	biological_process	response to ethanol
B	0055003	biological_process	cardiac myofibril assembly
B	0055008	biological_process	cardiac muscle tissue morphogenesis
B	0060047	biological_process	heart contraction
B	0060048	biological_process	cardiac muscle contraction
B	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
B	0090131	biological_process	mesenchyme migration
B	0098978	cellular_component	glutamatergic synapse
C	0000146	molecular_function	microfilament motor activity
C	0000166	molecular_function	nucleotide binding
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0007015	biological_process	actin filament organization
C	0009410	biological_process	response to xenobiotic stimulus
C	0010628	biological_process	positive regulation of gene expression
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0017022	molecular_function	myosin binding
C	0030017	cellular_component	sarcomere
C	0030027	cellular_component	lamellipodium
C	0030048	biological_process	actin filament-based movement
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031032	biological_process	actomyosin structure organization
C	0031674	cellular_component	I band
C	0033275	biological_process	actin-myosin filament sliding
C	0043066	biological_process	negative regulation of apoptotic process
C	0044297	cellular_component	cell body
C	0045202	cellular_component	synapse
C	0045471	biological_process	response to ethanol
C	0055003	biological_process	cardiac myofibril assembly
C	0055008	biological_process	cardiac muscle tissue morphogenesis
C	0060047	biological_process	heart contraction
C	0060048	biological_process	cardiac muscle contraction
C	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
C	0090131	biological_process	mesenchyme migration
C	0098978	cellular_component	glutamatergic synapse
D	0000146	molecular_function	microfilament motor activity
D	0000166	molecular_function	nucleotide binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0007015	biological_process	actin filament organization
D	0009410	biological_process	response to xenobiotic stimulus
D	0010628	biological_process	positive regulation of gene expression
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0017022	molecular_function	myosin binding
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030048	biological_process	actin filament-based movement
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031032	biological_process	actomyosin structure organization
D	0031674	cellular_component	I band
D	0033275	biological_process	actin-myosin filament sliding
D	0043066	biological_process	negative regulation of apoptotic process
D	0044297	cellular_component	cell body
D	0045202	cellular_component	synapse
D	0045471	biological_process	response to ethanol
D	0055003	biological_process	cardiac myofibril assembly
D	0055008	biological_process	cardiac muscle tissue morphogenesis
D	0060047	biological_process	heart contraction
D	0060048	biological_process	cardiac muscle contraction
D	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
D	0090131	biological_process	mesenchyme migration
D	0098978	cellular_component	glutamatergic synapse
E	0000146	molecular_function	microfilament motor activity
E	0000166	molecular_function	nucleotide binding
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005884	cellular_component	actin filament
E	0007015	biological_process	actin filament organization
E	0009410	biological_process	response to xenobiotic stimulus
E	0010628	biological_process	positive regulation of gene expression
E	0015629	cellular_component	actin cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0017022	molecular_function	myosin binding
E	0030017	cellular_component	sarcomere
E	0030027	cellular_component	lamellipodium
E	0030048	biological_process	actin filament-based movement
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031032	biological_process	actomyosin structure organization
E	0031674	cellular_component	I band
E	0033275	biological_process	actin-myosin filament sliding
E	0043066	biological_process	negative regulation of apoptotic process
E	0044297	cellular_component	cell body
E	0045202	cellular_component	synapse
E	0045471	biological_process	response to ethanol
E	0055003	biological_process	cardiac myofibril assembly
E	0055008	biological_process	cardiac muscle tissue morphogenesis
E	0060047	biological_process	heart contraction
E	0060048	biological_process	cardiac muscle contraction
E	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
E	0090131	biological_process	mesenchyme migration
E	0098978	cellular_component	glutamatergic synapse
F	0000146	molecular_function	microfilament motor activity
F	0000166	molecular_function	nucleotide binding
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005884	cellular_component	actin filament
F	0007015	biological_process	actin filament organization
F	0009410	biological_process	response to xenobiotic stimulus
F	0010628	biological_process	positive regulation of gene expression
F	0015629	cellular_component	actin cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0017022	molecular_function	myosin binding
F	0030017	cellular_component	sarcomere
F	0030027	cellular_component	lamellipodium
F	0030048	biological_process	actin filament-based movement
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031032	biological_process	actomyosin structure organization
F	0031674	cellular_component	I band
F	0033275	biological_process	actin-myosin filament sliding
F	0043066	biological_process	negative regulation of apoptotic process
F	0044297	cellular_component	cell body
F	0045202	cellular_component	synapse
F	0045471	biological_process	response to ethanol
F	0055003	biological_process	cardiac myofibril assembly
F	0055008	biological_process	cardiac muscle tissue morphogenesis
F	0060047	biological_process	heart contraction
F	0060048	biological_process	cardiac muscle contraction
F	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
F	0090131	biological_process	mesenchyme migration
F	0098978	cellular_component	glutamatergic synapse
I	0000146	molecular_function	microfilament motor activity
I	0000166	molecular_function	nucleotide binding
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0007015	biological_process	actin filament organization
I	0009410	biological_process	response to xenobiotic stimulus
I	0010628	biological_process	positive regulation of gene expression
I	0015629	cellular_component	actin cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0017022	molecular_function	myosin binding
I	0030017	cellular_component	sarcomere
I	0030027	cellular_component	lamellipodium
I	0030048	biological_process	actin filament-based movement
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0031032	biological_process	actomyosin structure organization
I	0031674	cellular_component	I band
I	0033275	biological_process	actin-myosin filament sliding
I	0043066	biological_process	negative regulation of apoptotic process
I	0044297	cellular_component	cell body
I	0045202	cellular_component	synapse
I	0045471	biological_process	response to ethanol
I	0055003	biological_process	cardiac myofibril assembly
I	0055008	biological_process	cardiac muscle tissue morphogenesis
I	0060047	biological_process	heart contraction
I	0060048	biological_process	cardiac muscle contraction
I	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
I	0090131	biological_process	mesenchyme migration
I	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
G	LEU232-GLU240

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR55-GLY65

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP358-GLU366

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU106-ARG118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"PubMed","id":"23911929","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P62739","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68032","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---