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8Q2L

Tau - AD-MIA4

Functional Information from GO Data
ChainGOidnamespacecontents
A0008017molecular_functionmicrotubule binding
A0015631molecular_functiontubulin binding
B0008017molecular_functionmicrotubule binding
B0015631molecular_functiontubulin binding
C0008017molecular_functionmicrotubule binding
C0015631molecular_functiontubulin binding
D0008017molecular_functionmicrotubule binding
D0015631molecular_functiontubulin binding
E0008017molecular_functionmicrotubule binding
E0015631molecular_functiontubulin binding
F0008017molecular_functionmicrotubule binding
F0015631molecular_functiontubulin binding
Functional Information from PROSITE/UniProt
site_idPS00229
Number of Residues13
DetailsTAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG
ChainResidueDetails
AGLY261-GLY273
AGLY292-GLY304
AGLY323-GLY335
AGLY355-GLY367

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues168
DetailsSITE: Not glycated => ECO:0000269|PubMed:9326300
ChainResidueDetails
ALYS83
ALYS254
BLYS298
BLYS311
BLYS317
BLYS321
BLYS331
BLYS340
BLYS343
BLYS370
BLYS375
BLYS383
ALYS257
BLYS385
BLYS395
BLYS438
ELYS83
ELYS103
EARG126
EGLY440
ELYS148
ELYS180
ELYS190
ALYS267
ELYS224
ELYS240
ELYS254
ELYS257
ELYS267
ELYS274
ELYS290
ELYS294
ELYS298
ELYS311
ALYS274
ELYS317
ELYS321
ELYS331
ELYS340
ELYS343
ELYS370
ELYS375
ELYS383
ELYS385
ELYS395
ALYS290
ELYS438
FLYS83
FLYS103
FARG126
FGLY440
FLYS148
FLYS180
FLYS190
FLYS224
FLYS240
ALYS294
FLYS254
FLYS257
FLYS267
FLYS274
FLYS290
FLYS294
FLYS298
FLYS311
FLYS317
FLYS321
ALYS298
FLYS331
FLYS340
FLYS343
FLYS370
FLYS375
FLYS383
FLYS385
FLYS395
FLYS438
ALYS311
ALYS317
ALYS321
ALYS103
ALYS331
ALYS340
ALYS343
ALYS370
ALYS375
ALYS383
ALYS385
ALYS395
ALYS438
DLYS83
AARG126
DLYS103
DARG126
DGLY440
DLYS148
DLYS180
DLYS190
DLYS224
DLYS240
DLYS254
DLYS257
AGLY440
DLYS267
DLYS274
DLYS290
DLYS294
DLYS298
DLYS311
DLYS317
DLYS321
DLYS331
DLYS340
ALYS148
DLYS343
DLYS370
DLYS375
DLYS383
DLYS385
DLYS395
DLYS438
CLYS83
CLYS103
CARG126
ALYS180
CGLY440
CLYS148
CLYS180
CLYS190
CLYS224
CLYS240
CLYS254
CLYS257
CLYS267
CLYS274
ALYS190
CLYS290
CLYS294
CLYS298
CLYS311
CLYS317
CLYS321
CLYS331
CLYS340
CLYS343
CLYS370
ALYS224
CLYS375
CLYS383
CLYS385
CLYS395
CLYS438
BLYS83
BLYS103
BARG126
BGLY440
BLYS148
ALYS240
BLYS180
BLYS190
BLYS224
BLYS240
BLYS254
BLYS257
BLYS267
BLYS274
BLYS290
BLYS294

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244
ChainResidueDetails
AALA61
DALA61
CALA61
BALA61
EALA61
FALA61

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081
ChainResidueDetails
ATYR77
DTYR77
CTYR77
BTYR77
ETYR77
FTYR77

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ATYR88
ETYR394
FTYR88
FTYR394
ATYR394
DTYR88
DTYR394
CTYR88
CTYR394
BTYR88
BTYR394
ETYR88

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332
ChainResidueDetails
AGLU105
EGLY120
FGLU105
FGLY120
AGLY120
DGLU105
DGLY120
CGLU105
CGLY120
BGLU105
BGLY120
EGLU105

site_idSWS_FT_FI6
Number of Residues30
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
AVAL128
DTHR403
CVAL128
CARG170
CTHR169
CTHR175
CTHR403
BVAL128
BARG170
BTHR169
BTHR175
AARG170
BTHR403
EVAL128
EARG170
ETHR169
ETHR175
ETHR403
FVAL128
FARG170
FTHR169
FTHR175
ATHR169
FTHR403
ATHR175
ATHR403
DVAL128
DARG170
DTHR169
DTHR175

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332
ChainResidueDetails
ALYS130
DLYS130
CLYS130
BLYS130
ELYS130
FLYS130

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696
ChainResidueDetails
AGLY273
DGLY273
CGLY273
BGLY273
EGLY273
FGLY273

site_idSWS_FT_FI9
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:9614189
ChainResidueDetails
ATHR153
DTHR153
CTHR153
BTHR153
ETHR153
FTHR153

site_idSWS_FT_FI10
Number of Residues12
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
AARG155
EARG349
FARG155
FARG349
AARG349
DARG155
DARG349
CARG155
CARG349
BARG155
BARG349
EARG155

site_idSWS_FT_FI11
Number of Residues66
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ALYS163
ALYS369
ALYS385
DLYS163
DLYS281
DLYS298
DLYS311
DLYS317
DLYS321
DLYS331
DLYS343
ALYS281
DLYS347
DLYS369
DLYS385
CLYS163
CLYS281
CLYS298
CLYS311
CLYS317
CLYS321
CLYS331
ALYS298
CLYS343
CLYS347
CLYS369
CLYS385
BLYS163
BLYS281
BLYS298
BLYS311
BLYS317
BLYS321
ALYS311
BLYS331
BLYS343
BLYS347
BLYS369
BLYS385
ELYS163
ELYS281
ELYS298
ELYS311
ELYS317
ALYS317
ELYS321
ELYS331
ELYS343
ELYS347
ELYS369
ELYS385
FLYS163
FLYS281
FLYS298
FLYS311
ALYS321
FLYS317
FLYS321
FLYS331
FLYS343
FLYS347
FLYS369
FLYS385
ALYS331
ALYS343
ALYS347

site_idSWS_FT_FI12
Number of Residues12
DetailsMOD_RES: Deamidated asparagine; in tau and PHF-tau; partial => ECO:0000269|PubMed:1512244
ChainResidueDetails
AASN167
EASN279
FASN167
FASN279
AASN279
DASN167
DASN279
CASN167
CASN279
BASN167
BASN279
EASN167

site_idSWS_FT_FI13
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:15546861
ChainResidueDetails
ATHR181
DTHR181
CTHR181
BTHR181
ETHR181
FTHR181

site_idSWS_FT_FI14
Number of Residues18
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ASER185
BSER185
BSER191
BSER195
ESER185
ESER191
ESER195
FSER185
FSER191
FSER195
ASER191
ASER195
DSER185
DSER191
DSER195
CSER185
CSER191
CSER195

site_idSWS_FT_FI15
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by TTBK1 => ECO:0000269|PubMed:16923168
ChainResidueDetails
ATYR197
DTYR197
CTYR197
BTYR197
ETYR197
FTYR197

site_idSWS_FT_FI16
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16923168
ChainResidueDetails
ASER198
DSER198
CSER198
BSER198
ESER198
FSER198

site_idSWS_FT_FI17
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189
ChainResidueDetails
ASER199
DSER199
CSER199
BSER199
ESER199
FSER199

site_idSWS_FT_FI18
Number of Residues6
DetailsMOD_RES: Phosphoserine; by CK1, PDPK1 and TTBK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER202
DSER202
CSER202
BSER202
ESER202
FSER202

site_idSWS_FT_FI19
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179
ChainResidueDetails
ATHR205
DTHR205
CTHR205
BTHR205
ETHR205
FTHR205

site_idSWS_FT_FI20
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189
ChainResidueDetails
ATHR212
DTHR212
CTHR212
BTHR212
ETHR212
FTHR212

site_idSWS_FT_FI21
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189
ChainResidueDetails
ASER214
DSER214
CSER214
BSER214
ESER214
FSER214

site_idSWS_FT_FI22
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179
ChainResidueDetails
ATHR217
DTHR217
CTHR217
BTHR217
ETHR217
FTHR217

site_idSWS_FT_FI23
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ALYS225
ELYS290
FLYS225
FLYS290
ALYS290
DLYS225
DLYS290
CLYS225
CLYS290
BLYS225
BLYS290
ELYS225

site_idSWS_FT_FI24
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR231
DTHR231
CTHR231
BTHR231
ETHR231
FTHR231

site_idSWS_FT_FI25
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER235
DSER235
CSER235
BSER235
ESER235
FSER235

site_idSWS_FT_FI26
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860
ChainResidueDetails
ASER237
DSER237
CSER237
BSER237
ESER237
FSER237

site_idSWS_FT_FI27
Number of Residues6
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ALYS259
DLYS259
CLYS259
BLYS259
ELYS259
FLYS259

site_idSWS_FT_FI28
Number of Residues6
DetailsMOD_RES: Phosphoserine; by MARK1, MARK2, MARK3, MARK4, BRSK1, BRSK2 and PHK => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860, ECO:0000269|PubMed:9614189
ChainResidueDetails
ASER262
DSER262
CSER262
BSER262
ESER262
FSER262

site_idSWS_FT_FI29
Number of Residues12
DetailsMOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:8999860
ChainResidueDetails
ASER285
ESER352
FSER285
FSER352
ASER352
DSER285
DSER352
CSER285
CSER352
BSER285
BSER352
ESER285

site_idSWS_FT_FI30
Number of Residues18
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316
ChainResidueDetails
ASER293
BSER293
BSER324
BSER356
ESER293
ESER324
ESER356
FSER293
FSER324
FSER356
ASER324
ASER356
DSER293
DSER324
DSER356
CSER293
CSER324
CSER356

site_idSWS_FT_FI31
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860
ChainResidueDetails
ASER305
DSER305
CSER305
BSER305
ESER305
FSER305

site_idSWS_FT_FI32
Number of Residues6
DetailsMOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER396
DSER396
CSER396
BSER396
ESER396
FSER396

site_idSWS_FT_FI33
Number of Residues6
DetailsMOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER400
DSER400
CSER400
BSER400
ESER400
FSER400

site_idSWS_FT_FI34
Number of Residues6
DetailsMOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER404
DSER404
CSER404
BSER404
ESER404
FSER404

site_idSWS_FT_FI35
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15546861, ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER409
DSER409
CSER409
BSER409
ESER409
FSER409

site_idSWS_FT_FI36
Number of Residues6
DetailsMOD_RES: Phosphoserine; by CaMK2 and TTBK1 => ECO:0000269|PubMed:16923168
ChainResidueDetails
ASER416
DSER416
CSER416
BSER416
ESER416
FSER416

site_idSWS_FT_FI37
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189
ChainResidueDetails
ASER422
DSER422
CSER422
BSER422
ESER422
FSER422

site_idSWS_FT_FI38
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by TTBK1 => ECO:0000269|PubMed:16923168
ChainResidueDetails
ATHR427
DTHR427
CTHR427
BTHR427
ETHR427
FTHR427

site_idSWS_FT_FI39
Number of Residues78
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300
ChainResidueDetails
AASP146
ALYS281
ALYS347
ALYS353
ALYS369
DASP146
DLYS150
DLYS163
DLYS174
DLYS225
DLYS234
DLYS259
DLYS280
DLYS281
DLYS347
DLYS353
DLYS369
CASP146
CLYS150
ALYS150
CLYS163
CLYS174
CLYS225
CLYS234
CLYS259
CLYS280
CLYS281
CLYS347
CLYS353
CLYS369
ALYS163
BASP146
BLYS150
BLYS163
BLYS174
BLYS225
BLYS234
BLYS259
BLYS280
BLYS281
ALYS174
BLYS347
BLYS353
BLYS369
EASP146
ELYS150
ELYS163
ELYS174
ELYS225
ELYS234
ALYS225
ELYS259
ELYS280
ELYS281
ELYS347
ELYS353
ELYS369
FASP146
FLYS150
FLYS163
ALYS234
FLYS174
FLYS225
FLYS234
FLYS259
FLYS280
FLYS281
FLYS347
FLYS353
FLYS369
ALYS259
ALYS280

site_idSWS_FT_FI40
Number of Residues12
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254
ChainResidueDetails
ASER208
ESER238
FSER208
FSER238
ASER238
DSER208
DSER238
CSER208
CSER238
BSER208
BSER238
ESER208

site_idSWS_FT_FI41
Number of Residues6
DetailsCARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254
ChainResidueDetails
ASER400
DSER400
CSER400
BSER400
ESER400
FSER400

site_idSWS_FT_FI42
Number of Residues18
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ALYS103
BLYS103
BLYS267
BLYS375
ELYS103
ELYS267
ELYS375
FLYS103
FLYS267
FLYS375
ALYS267
ALYS375
DLYS103
DLYS267
DLYS375
CLYS103
CLYS267
CLYS375

site_idSWS_FT_FI43
Number of Residues66
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637
ChainResidueDetails
ALYS369
ALYS385
DLYS259
DLYS281
DLYS298
DLYS317
DLYS321
DLYS331
DLYS343
ALYS259
DLYS347
DLYS369
DLYS385
CLYS259
CLYS281
CLYS298
CLYS317
CLYS321
CLYS331
ALYS281
CLYS343
CLYS347
CLYS369
CLYS385
BLYS259
BLYS281
BLYS298
BLYS317
BLYS321
ALYS298
BLYS331
BLYS343
BLYS347
BLYS369
BLYS385
ELYS259
ELYS281
ELYS298
ELYS317
ALYS317
ELYS321
ELYS331
ELYS343
ELYS347
ELYS369
ELYS385
FLYS259
FLYS281
FLYS298
ALYS321
FLYS317
FLYS321
FLYS331
FLYS343
FLYS347
FLYS369
FLYS385
ALYS331
ALYS343
ALYS347

site_idSWS_FT_FI44
Number of Residues18
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603
ChainResidueDetails
ALYS254
BLYS254
BLYS311
BLYS353
ELYS254
ELYS311
ELYS353
FLYS254
FLYS311
FLYS353
ALYS311
ALYS353
DLYS254
DLYS311
DLYS353
CLYS254
CLYS311
CLYS353

227111

PDB entries from 2024-11-06

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