8PTS

human GUK1 in complex with compound AT8001

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001917	cellular_component	photoreceptor inner segment
A	0004385	molecular_function	guanylate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006163	biological_process	purine nucleotide metabolic process
A	0006185	biological_process	dGDP biosynthetic process
A	0006805	biological_process	xenobiotic metabolic process
A	0015949	biological_process	nucleobase-containing small molecule interconversion
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0019673	biological_process	GDP-mannose metabolic process
A	0034436	biological_process	glycoprotein transport
A	0046037	biological_process	GMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046060	biological_process	dATP metabolic process
A	0046711	biological_process	GDP biosynthetic process
B	0001917	cellular_component	photoreceptor inner segment
B	0004385	molecular_function	guanylate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006163	biological_process	purine nucleotide metabolic process
B	0006185	biological_process	dGDP biosynthetic process
B	0006805	biological_process	xenobiotic metabolic process
B	0015949	biological_process	nucleobase-containing small molecule interconversion
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0019673	biological_process	GDP-mannose metabolic process
B	0034436	biological_process	glycoprotein transport
B	0046037	biological_process	GMP metabolic process
B	0046054	biological_process	dGMP metabolic process
B	0046060	biological_process	dATP metabolic process
B	0046711	biological_process	GDP biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00856
Number of Residues	18
Details	GUANYLATE_KINASE_1 Guanylate kinase-like signature. TTRnpRpgEenGkdYyFV

Chain	Residue	Details
A	THR39-VAL56

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q64520

Chain	Residue	Details
A	ARG44
A	ARG137
A	ARG148
B	ARG44
B	ARG137
B	ARG148

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q64520

Chain	Residue	Details
A	GLY14
A	SER37
A	ARG137
A	ASN171
B	GLY14
B	SER37
B	ARG137
B	ASN171

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	SER2
B	SER2

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