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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8PS2

Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam sample)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003824molecular_functioncatalytic activity
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0004321molecular_functionfatty-acyl-CoA synthase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005835cellular_componentfatty acid synthase complex
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0042759biological_processlong-chain fatty acid biosynthetic process
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0003824molecular_functioncatalytic activity
B0004312molecular_functionfatty acid synthase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0004321molecular_functionfatty-acyl-CoA synthase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005835cellular_componentfatty acid synthase complex
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0042759biological_processlong-chain fatty acid biosynthetic process
B0046872molecular_functionmetal ion binding
G0003824molecular_functioncatalytic activity
G0004312molecular_functionfatty acid synthase activity
G0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
G0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
G0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
G0004321molecular_functionfatty-acyl-CoA synthase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005811cellular_componentlipid droplet
G0005829cellular_componentcytosol
G0005835cellular_componentfatty acid synthase complex
G0006629biological_processlipid metabolic process
G0006631biological_processfatty acid metabolic process
G0006633biological_processfatty acid biosynthetic process
G0016297molecular_functionfatty acyl-[ACP] hydrolase activity
G0016409molecular_functionpalmitoyltransferase activity
G0016491molecular_functionoxidoreductase activity
G0016740molecular_functiontransferase activity
G0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
G0016787molecular_functionhydrolase activity
G0016829molecular_functionlyase activity
G0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G0042759biological_processlong-chain fatty acid biosynthetic process
G0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL
ChainResidueDetails
ALEU175-LEU190
site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV
ChainResidueDetails
AGLY1296-VAL1312
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues534
DetailsDomain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues199
DetailsRegion: {"description":"Beta-ketoacyl reductase"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsActive site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues22
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19679086","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues75
DetailsDomain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17431182","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues125
DetailsDomain: {"description":"MaoC-like"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues388
DetailsRegion: {"description":"Enoyl reductase"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues482
DetailsRegion: {"description":"Dehydratase"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues218
DetailsRegion: {"description":"Malonyl/palmitoyl transferase"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsActive site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsActive site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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