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8PRW

Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0004321molecular_functionfatty-acyl-CoA synthase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005835cellular_componentfatty acid synthase complex
A0006633biological_processfatty acid biosynthetic process
A0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0042759biological_processlong-chain fatty acid biosynthetic process
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0004312molecular_functionfatty acid synthase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0004321molecular_functionfatty-acyl-CoA synthase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005835cellular_componentfatty acid synthase complex
B0006633biological_processfatty acid biosynthetic process
B0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0042759biological_processlong-chain fatty acid biosynthetic process
B0046872molecular_functionmetal ion binding
C0000287molecular_functionmagnesium ion binding
C0004312molecular_functionfatty acid synthase activity
C0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
C0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C0004321molecular_functionfatty-acyl-CoA synthase activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005835cellular_componentfatty acid synthase complex
C0006633biological_processfatty acid biosynthetic process
C0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0042759biological_processlong-chain fatty acid biosynthetic process
C0046872molecular_functionmetal ion binding
D0000287molecular_functionmagnesium ion binding
D0004312molecular_functionfatty acid synthase activity
D0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
D0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D0004321molecular_functionfatty-acyl-CoA synthase activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005835cellular_componentfatty acid synthase complex
D0006633biological_processfatty acid biosynthetic process
D0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
D0016491molecular_functionoxidoreductase activity
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0042759biological_processlong-chain fatty acid biosynthetic process
D0046872molecular_functionmetal ion binding
E0000287molecular_functionmagnesium ion binding
E0004312molecular_functionfatty acid synthase activity
E0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
E0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E0004321molecular_functionfatty-acyl-CoA synthase activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0005835cellular_componentfatty acid synthase complex
E0006633biological_processfatty acid biosynthetic process
E0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
E0016491molecular_functionoxidoreductase activity
E0016740molecular_functiontransferase activity
E0016746molecular_functionacyltransferase activity
E0042759biological_processlong-chain fatty acid biosynthetic process
E0046872molecular_functionmetal ion binding
F0000287molecular_functionmagnesium ion binding
F0004312molecular_functionfatty acid synthase activity
F0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
F0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F0004321molecular_functionfatty-acyl-CoA synthase activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005835cellular_componentfatty acid synthase complex
F0006633biological_processfatty acid biosynthetic process
F0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
F0016491molecular_functionoxidoreductase activity
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0042759biological_processlong-chain fatty acid biosynthetic process
F0046872molecular_functionmetal ion binding
G0004312molecular_functionfatty acid synthase activity
G0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
G0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
G0004317molecular_function(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
G0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
G0004321molecular_functionfatty-acyl-CoA synthase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005811cellular_componentlipid droplet
G0005829cellular_componentcytosol
G0005835cellular_componentfatty acid synthase complex
G0006633biological_processfatty acid biosynthetic process
G0016297molecular_functionfatty acyl-[ACP] hydrolase activity
G0016409molecular_functionpalmitoyltransferase activity
G0016491molecular_functionoxidoreductase activity
G0016740molecular_functiontransferase activity
G0016787molecular_functionhydrolase activity
G0016829molecular_functionlyase activity
G0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G0042759biological_processlong-chain fatty acid biosynthetic process
G0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
H0004312molecular_functionfatty acid synthase activity
H0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
H0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
H0004317molecular_function(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
H0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
H0004321molecular_functionfatty-acyl-CoA synthase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005811cellular_componentlipid droplet
H0005829cellular_componentcytosol
H0005835cellular_componentfatty acid synthase complex
H0006633biological_processfatty acid biosynthetic process
H0016297molecular_functionfatty acyl-[ACP] hydrolase activity
H0016409molecular_functionpalmitoyltransferase activity
H0016491molecular_functionoxidoreductase activity
H0016740molecular_functiontransferase activity
H0016787molecular_functionhydrolase activity
H0016829molecular_functionlyase activity
H0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H0042759biological_processlong-chain fatty acid biosynthetic process
H0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
I0004312molecular_functionfatty acid synthase activity
I0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
I0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
I0004317molecular_function(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
I0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
I0004321molecular_functionfatty-acyl-CoA synthase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005811cellular_componentlipid droplet
I0005829cellular_componentcytosol
I0005835cellular_componentfatty acid synthase complex
I0006633biological_processfatty acid biosynthetic process
I0016297molecular_functionfatty acyl-[ACP] hydrolase activity
I0016409molecular_functionpalmitoyltransferase activity
I0016491molecular_functionoxidoreductase activity
I0016740molecular_functiontransferase activity
I0016787molecular_functionhydrolase activity
I0016829molecular_functionlyase activity
I0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I0042759biological_processlong-chain fatty acid biosynthetic process
I0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
J0004312molecular_functionfatty acid synthase activity
J0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
J0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
J0004317molecular_function(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
J0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
J0004321molecular_functionfatty-acyl-CoA synthase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005811cellular_componentlipid droplet
J0005829cellular_componentcytosol
J0005835cellular_componentfatty acid synthase complex
J0006633biological_processfatty acid biosynthetic process
J0016297molecular_functionfatty acyl-[ACP] hydrolase activity
J0016409molecular_functionpalmitoyltransferase activity
J0016491molecular_functionoxidoreductase activity
J0016740molecular_functiontransferase activity
J0016787molecular_functionhydrolase activity
J0016829molecular_functionlyase activity
J0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J0042759biological_processlong-chain fatty acid biosynthetic process
J0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
K0004312molecular_functionfatty acid synthase activity
K0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
K0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
K0004317molecular_function(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
K0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
K0004321molecular_functionfatty-acyl-CoA synthase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005811cellular_componentlipid droplet
K0005829cellular_componentcytosol
K0005835cellular_componentfatty acid synthase complex
K0006633biological_processfatty acid biosynthetic process
K0016297molecular_functionfatty acyl-[ACP] hydrolase activity
K0016409molecular_functionpalmitoyltransferase activity
K0016491molecular_functionoxidoreductase activity
K0016740molecular_functiontransferase activity
K0016787molecular_functionhydrolase activity
K0016829molecular_functionlyase activity
K0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
K0042759biological_processlong-chain fatty acid biosynthetic process
K0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
L0004312molecular_functionfatty acid synthase activity
L0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
L0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
L0004317molecular_function(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
L0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
L0004321molecular_functionfatty-acyl-CoA synthase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005811cellular_componentlipid droplet
L0005829cellular_componentcytosol
L0005835cellular_componentfatty acid synthase complex
L0006633biological_processfatty acid biosynthetic process
L0016297molecular_functionfatty acyl-[ACP] hydrolase activity
L0016409molecular_functionpalmitoyltransferase activity
L0016491molecular_functionoxidoreductase activity
L0016740molecular_functiontransferase activity
L0016787molecular_functionhydrolase activity
L0016829molecular_functionlyase activity
L0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L0042759biological_processlong-chain fatty acid biosynthetic process
L0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL
ChainResidueDetails
ALEU175-LEU190

site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV
ChainResidueDetails
AGLY1296-VAL1312

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: For acetyltransferase activity => ECO:0000250
ChainResidueDetails
EHIS1542
EHIS1583
FCYS1305
FHIS1542
FHIS1583
JSER274
ISER274
GSER274
DCYS1305
DHIS1542
DHIS1583
ECYS1305
HSER274
KSER274
LSER274
CCYS1305
CHIS1542
CHIS1583

site_idSWS_FT_FI2
Number of Residues6
DetailsACT_SITE: For malonyltransferase activity => ECO:0000250
ChainResidueDetails
BILE1871
BSER1872
BHIS1873
CASP1772
CVAL1773
CGLU1774
JJ8W1808
CGLU1817
CARG1841
CILE1871
CSER1872
CHIS1873
DASP1772
DVAL1773
DGLU1774
DGLU1817
DARG1841
IJ8W1808
GJ8W1808
BVAL1773
BGLU1774
BGLU1817
BARG1841
DILE1871
DSER1872
DHIS1873
EASP1772
EVAL1773
EGLU1774
EGLU1817
EARG1841
EILE1871
ESER1872
HJ8W1808
EHIS1873
FASP1772
FVAL1773
FGLU1774
FGLU1817
FARG1841
FILE1871
FSER1872
FHIS1873
KJ8W1808
LJ8W1808
ASER1872
AHIS1873
BASP1772

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
JMET1
GMET1
ESER1808
FTYR1798
FSER1808
IMET1
HMET1
KMET1
LMET1
DTYR1798
DSER1808
ETYR1798

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198
ChainResidueDetails
JTHR733
GTHR733
ITHR733
HTHR733
KTHR733
LTHR733

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
JSER1121
GSER1121
ISER1121
HSER1121
KSER1121
LSER1121

site_idSWS_FT_FI6
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
BSER523
GLYS1364
LLYS1364
JLYS1364
DSER523
ILYS1364
FSER523
HLYS1364
KLYS1364

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950
ChainResidueDetails
ASER1440
ASER958
ESER1440
FSER958
FSER1440
BSER958
BSER1440
CSER958
CSER1440
DSER958
DSER1440
ESER958

site_idSWS_FT_FI8
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ALYS37
FLYS37
BLYS37
CLYS37
DLYS37
ELYS37

221051

PDB entries from 2024-06-12

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