8PRW

Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016746	molecular_function	acyltransferase activity
A	0019367	biological_process	fatty acid elongation, saturated fatty acid
A	0030497	biological_process	fatty acid elongation
A	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016746	molecular_function	acyltransferase activity
B	0019367	biological_process	fatty acid elongation, saturated fatty acid
B	0030497	biological_process	fatty acid elongation
B	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004312	molecular_function	fatty acid synthase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0004321	molecular_function	fatty-acyl-CoA synthase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005835	cellular_component	fatty acid synthase complex
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0016746	molecular_function	acyltransferase activity
C	0019367	biological_process	fatty acid elongation, saturated fatty acid
C	0030497	biological_process	fatty acid elongation
C	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004321	molecular_function	fatty-acyl-CoA synthase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005835	cellular_component	fatty acid synthase complex
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0016746	molecular_function	acyltransferase activity
D	0019367	biological_process	fatty acid elongation, saturated fatty acid
D	0030497	biological_process	fatty acid elongation
D	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004312	molecular_function	fatty acid synthase activity
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006633	biological_process	fatty acid biosynthetic process
E	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
E	0016746	molecular_function	acyltransferase activity
E	0019367	biological_process	fatty acid elongation, saturated fatty acid
E	0030497	biological_process	fatty acid elongation
E	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004312	molecular_function	fatty acid synthase activity
F	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
F	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0004321	molecular_function	fatty-acyl-CoA synthase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005835	cellular_component	fatty acid synthase complex
F	0006633	biological_process	fatty acid biosynthetic process
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0016746	molecular_function	acyltransferase activity
F	0019367	biological_process	fatty acid elongation, saturated fatty acid
F	0030497	biological_process	fatty acid elongation
F	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0004312	molecular_function	fatty acid synthase activity
G	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
G	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0004321	molecular_function	fatty-acyl-CoA synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0005835	cellular_component	fatty acid synthase complex
G	0006633	biological_process	fatty acid biosynthetic process
G	0008410	molecular_function	CoA-transferase activity
G	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
G	0016409	molecular_function	palmitoyltransferase activity
G	0016740	molecular_function	transferase activity
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0019367	biological_process	fatty acid elongation, saturated fatty acid
G	0030497	biological_process	fatty acid elongation
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
H	0004312	molecular_function	fatty acid synthase activity
H	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
H	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0004321	molecular_function	fatty-acyl-CoA synthase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0005835	cellular_component	fatty acid synthase complex
H	0006633	biological_process	fatty acid biosynthetic process
H	0008410	molecular_function	CoA-transferase activity
H	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
H	0016409	molecular_function	palmitoyltransferase activity
H	0016740	molecular_function	transferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H	0019367	biological_process	fatty acid elongation, saturated fatty acid
H	0030497	biological_process	fatty acid elongation
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006633	biological_process	fatty acid biosynthetic process
I	0008410	molecular_function	CoA-transferase activity
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016740	molecular_function	transferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0019367	biological_process	fatty acid elongation, saturated fatty acid
I	0030497	biological_process	fatty acid elongation
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0004312	molecular_function	fatty acid synthase activity
J	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
J	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
J	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J	0004321	molecular_function	fatty-acyl-CoA synthase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005811	cellular_component	lipid droplet
J	0005829	cellular_component	cytosol
J	0005835	cellular_component	fatty acid synthase complex
J	0006633	biological_process	fatty acid biosynthetic process
J	0008410	molecular_function	CoA-transferase activity
J	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
J	0016409	molecular_function	palmitoyltransferase activity
J	0016740	molecular_function	transferase activity
J	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
J	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J	0019367	biological_process	fatty acid elongation, saturated fatty acid
J	0030497	biological_process	fatty acid elongation
J	0042759	biological_process	long-chain fatty acid biosynthetic process
J	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0004312	molecular_function	fatty acid synthase activity
K	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
K	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
K	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K	0004321	molecular_function	fatty-acyl-CoA synthase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005811	cellular_component	lipid droplet
K	0005829	cellular_component	cytosol
K	0005835	cellular_component	fatty acid synthase complex
K	0006633	biological_process	fatty acid biosynthetic process
K	0008410	molecular_function	CoA-transferase activity
K	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
K	0016409	molecular_function	palmitoyltransferase activity
K	0016740	molecular_function	transferase activity
K	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
K	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
K	0019367	biological_process	fatty acid elongation, saturated fatty acid
K	0030497	biological_process	fatty acid elongation
K	0042759	biological_process	long-chain fatty acid biosynthetic process
K	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
L	0004312	molecular_function	fatty acid synthase activity
L	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
L	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0004321	molecular_function	fatty-acyl-CoA synthase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005811	cellular_component	lipid droplet
L	0005829	cellular_component	cytosol
L	0005835	cellular_component	fatty acid synthase complex
L	0006633	biological_process	fatty acid biosynthetic process
L	0008410	molecular_function	CoA-transferase activity
L	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
L	0016409	molecular_function	palmitoyltransferase activity
L	0016740	molecular_function	transferase activity
L	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
L	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L	0019367	biological_process	fatty acid elongation, saturated fatty acid
L	0030497	biological_process	fatty acid elongation
L	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL

Chain	Residue	Details
A	LEU175-LEU190

---

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
A	GLY1296-VAL1312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3204
Details	Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1194
Details	Region: {"description":"Beta-ketoacyl reductase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	72
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19679086","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	750
Details	Domain: {"description":"MaoC-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2328
Details	Region: {"description":"Enoyl reductase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2892
Details	Region: {"description":"Dehydratase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---