8PM6

Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005768	cellular_component	endosome
A	0005886	cellular_component	plasma membrane
A	0006631	biological_process	fatty acid metabolic process
A	0006699	biological_process	bile acid biosynthetic process
A	0006805	biological_process	xenobiotic metabolic process
A	0006855	biological_process	xenobiotic transmembrane transport
A	0006869	biological_process	lipid transport
A	0008206	biological_process	bile acid metabolic process
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0009986	cellular_component	cell surface
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015126	molecular_function	canalicular bile acid transmembrane transporter activity
A	0015432	molecular_function	ABC-type bile acid transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015722	biological_process	canalicular bile acid transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016567	biological_process	protein ubiquitination
A	0016887	molecular_function	ATP hydrolysis activity
A	0031998	biological_process	regulation of fatty acid beta-oxidation
A	0042632	biological_process	cholesterol homeostasis
A	0045177	cellular_component	apical part of cell
A	0046581	cellular_component	intercellular canaliculus
A	0046618	biological_process	xenobiotic export from cell
A	0046691	cellular_component	intracellular canaliculus
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0055085	biological_process	transmembrane transport
A	0055088	biological_process	lipid homeostasis
A	0055091	biological_process	phospholipid homeostasis
A	0070062	cellular_component	extracellular exosome
A	0120189	biological_process	positive regulation of bile acid secretion
A	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. MSGGQKQRVAIARAL

Chain	Residue	Details
A	MET559-LEU573

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	42
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	110
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"Mediates internalization from the plasma membrane","evidences":[{"source":"PubMed","id":"22262466","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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