Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8PJB

Cryo-EM structure of MLE in complex with UUC RNA and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000228	cellular_component	nuclear chromosome
A	0000785	cellular_component	chromatin
A	0000805	cellular_component	X chromosome
A	0001069	molecular_function	regulatory region RNA binding
A	0003676	molecular_function	nucleic acid binding
A	0003678	molecular_function	DNA helicase activity
A	0003682	molecular_function	chromatin binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003725	molecular_function	double-stranded RNA binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0008340	biological_process	determination of adult lifespan
A	0009047	biological_process	dosage compensation by hyperactivation of X chromosome
A	0016456	cellular_component	X chromosome located dosage compensation complex, transcription activating
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031453	biological_process	positive regulation of heterochromatin formation
A	0033679	molecular_function	3'-5' DNA/RNA helicase activity
A	0034458	molecular_function	3'-5' RNA helicase activity
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042714	biological_process	dosage compensation complex assembly
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0045433	biological_process	male courtship behavior, veined wing generated song production
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048675	biological_process	axon extension
A	0050684	biological_process	regulation of mRNA processing
A	0071168	biological_process	protein localization to chromatin
A	0072487	cellular_component	MSL complex
A	0106222	molecular_function	lncRNA binding
A	1990904	cellular_component	ribonucleoprotein complex
A	2000765	biological_process	regulation of cytoplasmic translation

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ShIIVDEIHE

Chain	Residue	Details
A	SER502-GLU511

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"DRBM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00266","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	174
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details