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8PIV

Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0038023molecular_functionsignaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0038023molecular_functionsignaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
E0005245molecular_functionvoltage-gated calcium channel activity
E0005246molecular_functioncalcium channel regulator activity
E0005262molecular_functioncalcium channel activity
E0005515molecular_functionprotein binding
E0005891cellular_componentvoltage-gated calcium channel complex
E0006612biological_processprotein targeting to membrane
E0006816biological_processcalcium ion transport
E0007528biological_processneuromuscular junction development
E0009986cellular_componentcell surface
E0014069cellular_componentpostsynaptic density
E0016020cellular_componentmembrane
E0016247molecular_functionchannel regulator activity
E0019226biological_processtransmission of nerve impulse
E0032281cellular_componentAMPA glutamate receptor complex
E0034702cellular_componentmonoatomic ion channel complex
E0035255molecular_functionionotropic glutamate receptor binding
E0036477cellular_componentsomatodendritic compartment
E0042391biological_processregulation of membrane potential
E0043005cellular_componentneuron projection
E0044300cellular_componentcerebellar mossy fiber
E0045202cellular_componentsynapse
E0050877biological_processnervous system process
E0051592biological_processresponse to calcium ion
E0051899biological_processmembrane depolarization
E0051968biological_processpositive regulation of synaptic transmission, glutamatergic
E0060081biological_processmembrane hyperpolarization
E0060082biological_processeye blink reflex
E0070588biological_processcalcium ion transmembrane transport
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098686cellular_componenthippocampal mossy fiber to CA3 synapse
E0098839cellular_componentpostsynaptic density membrane
E0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
E0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
E0098978cellular_componentglutamatergic synapse
E0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
E0099590biological_processneurotransmitter receptor internalization
E0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
E1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
E2000311biological_processregulation of AMPA receptor activity
F0005245molecular_functionvoltage-gated calcium channel activity
F0005246molecular_functioncalcium channel regulator activity
F0005262molecular_functioncalcium channel activity
F0005515molecular_functionprotein binding
F0005891cellular_componentvoltage-gated calcium channel complex
F0006612biological_processprotein targeting to membrane
F0006816biological_processcalcium ion transport
F0007528biological_processneuromuscular junction development
F0009986cellular_componentcell surface
F0014069cellular_componentpostsynaptic density
F0016020cellular_componentmembrane
F0016247molecular_functionchannel regulator activity
F0019226biological_processtransmission of nerve impulse
F0032281cellular_componentAMPA glutamate receptor complex
F0034702cellular_componentmonoatomic ion channel complex
F0035255molecular_functionionotropic glutamate receptor binding
F0036477cellular_componentsomatodendritic compartment
F0042391biological_processregulation of membrane potential
F0043005cellular_componentneuron projection
F0044300cellular_componentcerebellar mossy fiber
F0045202cellular_componentsynapse
F0050877biological_processnervous system process
F0051592biological_processresponse to calcium ion
F0051899biological_processmembrane depolarization
F0051968biological_processpositive regulation of synaptic transmission, glutamatergic
F0060081biological_processmembrane hyperpolarization
F0060082biological_processeye blink reflex
F0070588biological_processcalcium ion transmembrane transport
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098686cellular_componenthippocampal mossy fiber to CA3 synapse
F0098839cellular_componentpostsynaptic density membrane
F0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
F0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
F0098978cellular_componentglutamatergic synapse
F0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
F0099590biological_processneurotransmitter receptor internalization
F0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
F1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
F2000311biological_processregulation of AMPA receptor activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005246molecular_functioncalcium channel regulator activity
G0005262molecular_functioncalcium channel activity
G0005515molecular_functionprotein binding
G0005891cellular_componentvoltage-gated calcium channel complex
G0006612biological_processprotein targeting to membrane
G0006816biological_processcalcium ion transport
G0007528biological_processneuromuscular junction development
G0009986cellular_componentcell surface
G0014069cellular_componentpostsynaptic density
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0019226biological_processtransmission of nerve impulse
G0032281cellular_componentAMPA glutamate receptor complex
G0034702cellular_componentmonoatomic ion channel complex
G0035255molecular_functionionotropic glutamate receptor binding
G0036477cellular_componentsomatodendritic compartment
G0042391biological_processregulation of membrane potential
G0043005cellular_componentneuron projection
G0044300cellular_componentcerebellar mossy fiber
G0045202cellular_componentsynapse
G0050877biological_processnervous system process
G0051592biological_processresponse to calcium ion
G0051899biological_processmembrane depolarization
G0051968biological_processpositive regulation of synaptic transmission, glutamatergic
G0060081biological_processmembrane hyperpolarization
G0060082biological_processeye blink reflex
G0070588biological_processcalcium ion transmembrane transport
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098686cellular_componenthippocampal mossy fiber to CA3 synapse
G0098839cellular_componentpostsynaptic density membrane
G0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
G0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
G0098978cellular_componentglutamatergic synapse
G0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
G0099590biological_processneurotransmitter receptor internalization
G0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
G1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
G2000311biological_processregulation of AMPA receptor activity
H0005245molecular_functionvoltage-gated calcium channel activity
H0005246molecular_functioncalcium channel regulator activity
H0005262molecular_functioncalcium channel activity
H0005515molecular_functionprotein binding
H0005891cellular_componentvoltage-gated calcium channel complex
H0006612biological_processprotein targeting to membrane
H0006816biological_processcalcium ion transport
H0007528biological_processneuromuscular junction development
H0009986cellular_componentcell surface
H0014069cellular_componentpostsynaptic density
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0019226biological_processtransmission of nerve impulse
H0032281cellular_componentAMPA glutamate receptor complex
H0034702cellular_componentmonoatomic ion channel complex
H0035255molecular_functionionotropic glutamate receptor binding
H0036477cellular_componentsomatodendritic compartment
H0042391biological_processregulation of membrane potential
H0043005cellular_componentneuron projection
H0044300cellular_componentcerebellar mossy fiber
H0045202cellular_componentsynapse
H0050877biological_processnervous system process
H0051592biological_processresponse to calcium ion
H0051899biological_processmembrane depolarization
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0060081biological_processmembrane hyperpolarization
H0060082biological_processeye blink reflex
H0070588biological_processcalcium ion transmembrane transport
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098686cellular_componenthippocampal mossy fiber to CA3 synapse
H0098839cellular_componentpostsynaptic density membrane
H0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
H0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
H0098978cellular_componentglutamatergic synapse
H0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
H0099590biological_processneurotransmitter receptor internalization
H0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
H1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
H2000311biological_processregulation of AMPA receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues320
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
EMET10-THR30
GSER104-ALA124
GILE134-ILE154
GPHE182-ILE202
HMET10-THR30
HSER104-ALA124
HILE134-ILE154
HPHE182-ILE202
ESER104-ALA124
EILE134-ILE154
EPHE182-ILE202
FMET10-THR30
FSER104-ALA124
FILE134-ILE154
FPHE182-ILE202
GMET10-THR30

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ESER253
FSER253
GSER253
HSER253

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O88602
ChainResidueDetails
ETYR271
FTYR271
GTYR271
HTYR271

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by PKA => ECO:0000250|UniProtKB:O88602
ChainResidueDetails
ETHR321
FTHR321
GTHR321
HTHR321

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN48
FASN48
GASN48
HASN48

226707

PDB entries from 2024-10-30

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