8PIU
60-meric complex of dihydrolipoamide acetyltransferase (E2) of the human pyruvate dehydrogenase complex
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PalSPtMTMGTV |
| Chain | Residue | Details |
| B | PRO224-VAL235 |
| site_id | PS00189 |
| Number of Residues | 30 |
| Details | LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdkInegDLIaeVETdKATvgFesleeCyM |
| Chain | Residue | Details |
| B | GLY116-MET145 | |
| B | GLY243-LEU272 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q9N0F1 |
| Chain | Residue | Details |
| B | HIS620 | |
| B | ASP624 | |
| AB | HIS620 | |
| AB | ASP624 | |
| A | HIS620 | |
| A | ASP624 | |
| BB | HIS620 | |
| BB | ASP624 | |
| CB | HIS620 | |
| CB | ASP624 | |
| DB | HIS620 | |
| DB | ASP624 | |
| EB | HIS620 | |
| EB | ASP624 | |
| FB | HIS620 | |
| FB | ASP624 | |
| GB | HIS620 | |
| GB | ASP624 | |
| HB | HIS620 | |
| HB | ASP624 | |
| IB | HIS620 | |
| IB | ASP624 | |
| C | HIS620 | |
| C | ASP624 | |
| D | HIS620 | |
| D | ASP624 | |
| E | HIS620 | |
| E | ASP624 | |
| F | HIS620 | |
| F | ASP624 | |
| G | HIS620 | |
| G | ASP624 | |
| H | HIS620 | |
| H | ASP624 | |
| I | HIS620 | |
| I | ASP624 | |
| J | HIS620 | |
| J | ASP624 | |
| K | HIS620 | |
| K | ASP624 | |
| L | HIS620 | |
| L | ASP624 | |
| M | HIS620 | |
| M | ASP624 | |
| N | HIS620 | |
| N | ASP624 | |
| O | HIS620 | |
| O | ASP624 | |
| P | HIS620 | |
| P | ASP624 | |
| Q | HIS620 | |
| Q | ASP624 | |
| R | HIS620 | |
| R | ASP624 | |
| BA | HIS620 | |
| BA | ASP624 | |
| S | HIS620 | |
| S | ASP624 | |
| T | HIS620 | |
| T | ASP624 | |
| V | HIS620 | |
| V | ASP624 | |
| W | HIS620 | |
| W | ASP624 | |
| X | HIS620 | |
| X | ASP624 | |
| Y | HIS620 | |
| Y | ASP624 | |
| Z | HIS620 | |
| Z | ASP624 | |
| AA | HIS620 | |
| AA | ASP624 | |
| CA | HIS620 | |
| CA | ASP624 | |
| DA | HIS620 | |
| DA | ASP624 | |
| EA | HIS620 | |
| EA | ASP624 | |
| FA | HIS620 | |
| FA | ASP624 | |
| GA | HIS620 | |
| GA | ASP624 | |
| HA | HIS620 | |
| HA | ASP624 | |
| IA | HIS620 | |
| IA | ASP624 | |
| JA | HIS620 | |
| JA | ASP624 | |
| KA | HIS620 | |
| KA | ASP624 | |
| LA | HIS620 | |
| LA | ASP624 | |
| MA | HIS620 | |
| MA | ASP624 | |
| NA | HIS620 | |
| NA | ASP624 | |
| OA | HIS620 | |
| OA | ASP624 | |
| PA | HIS620 | |
| PA | ASP624 | |
| QA | HIS620 | |
| QA | ASP624 | |
| RA | HIS620 | |
| RA | ASP624 | |
| SA | HIS620 | |
| SA | ASP624 | |
| TA | HIS620 | |
| TA | ASP624 | |
| UA | HIS620 | |
| UA | ASP624 | |
| VA | HIS620 | |
| VA | ASP624 | |
| WA | HIS620 | |
| WA | ASP624 | |
| XA | HIS620 | |
| XA | ASP624 | |
| YA | HIS620 | |
| YA | ASP624 | |
| ZA | HIS620 | |
| ZA | ASP624 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 300 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P11181 |
| Chain | Residue | Details |
| B | ARG461 | |
| B | SER475 | |
| B | SER566 | |
| B | ASN567 | |
| B | GLY591 | |
| AB | ARG461 | |
| AB | SER475 | |
| AB | SER566 | |
| AB | ASN567 | |
| AB | GLY591 | |
| A | ARG461 | |
| A | SER475 | |
| A | SER566 | |
| A | ASN567 | |
| A | GLY591 | |
| BB | ARG461 | |
| BB | SER475 | |
| BB | SER566 | |
| BB | ASN567 | |
| BB | GLY591 | |
| CB | ARG461 | |
| CB | SER475 | |
| CB | SER566 | |
| CB | ASN567 | |
| CB | GLY591 | |
| DB | ARG461 | |
| DB | SER475 | |
| DB | SER566 | |
| DB | ASN567 | |
| DB | GLY591 | |
| EB | ARG461 | |
| EB | SER475 | |
| EB | SER566 | |
| EB | ASN567 | |
| EB | GLY591 | |
| FB | ARG461 | |
| FB | SER475 | |
| FB | SER566 | |
| FB | ASN567 | |
| FB | GLY591 | |
| GB | ARG461 | |
| GB | SER475 | |
| GB | SER566 | |
| GB | ASN567 | |
| GB | GLY591 | |
| HB | ARG461 | |
| HB | SER475 | |
| HB | SER566 | |
| HB | ASN567 | |
| HB | GLY591 | |
| IB | ARG461 | |
| IB | SER475 | |
| IB | SER566 | |
| IB | ASN567 | |
| IB | GLY591 | |
| C | ARG461 | |
| C | SER475 | |
| C | SER566 | |
| C | ASN567 | |
| C | GLY591 | |
| D | ARG461 | |
| D | SER475 | |
| D | SER566 | |
| D | ASN567 | |
| D | GLY591 | |
| E | ARG461 | |
| E | SER475 | |
| E | SER566 | |
| E | ASN567 | |
| E | GLY591 | |
| F | ARG461 | |
| F | SER475 | |
| F | SER566 | |
| F | ASN567 | |
| F | GLY591 | |
| G | ARG461 | |
| G | SER475 | |
| G | SER566 | |
| G | ASN567 | |
| G | GLY591 | |
| H | ARG461 | |
| H | SER475 | |
| H | SER566 | |
| H | ASN567 | |
| H | GLY591 | |
| I | ARG461 | |
| I | SER475 | |
| I | SER566 | |
| I | ASN567 | |
| I | GLY591 | |
| J | ARG461 | |
| J | SER475 | |
| J | SER566 | |
| J | ASN567 | |
| J | GLY591 | |
| K | ARG461 | |
| K | SER475 | |
| K | SER566 | |
| K | ASN567 | |
| K | GLY591 | |
| L | ARG461 | |
| L | SER475 | |
| L | SER566 | |
| L | ASN567 | |
| L | GLY591 | |
| M | ARG461 | |
| M | SER475 | |
| M | SER566 | |
| M | ASN567 | |
| M | GLY591 | |
| N | ARG461 | |
| N | SER475 | |
| N | SER566 | |
| N | ASN567 | |
| N | GLY591 | |
| O | ARG461 | |
| O | SER475 | |
| O | SER566 | |
| O | ASN567 | |
| O | GLY591 | |
| P | ARG461 | |
| P | SER475 | |
| P | SER566 | |
| P | ASN567 | |
| P | GLY591 | |
| Q | ARG461 | |
| Q | SER475 | |
| Q | SER566 | |
| Q | ASN567 | |
| Q | GLY591 | |
| R | ARG461 | |
| R | SER475 | |
| R | SER566 | |
| R | ASN567 | |
| R | GLY591 | |
| BA | ARG461 | |
| BA | SER475 | |
| BA | SER566 | |
| BA | ASN567 | |
| BA | GLY591 | |
| S | ARG461 | |
| S | SER475 | |
| S | SER566 | |
| S | ASN567 | |
| S | GLY591 | |
| T | ARG461 | |
| T | SER475 | |
| T | SER566 | |
| T | ASN567 | |
| T | GLY591 | |
| V | ARG461 | |
| V | SER475 | |
| V | SER566 | |
| V | ASN567 | |
| V | GLY591 | |
| W | ARG461 | |
| W | SER475 | |
| W | SER566 | |
| W | ASN567 | |
| W | GLY591 | |
| X | ARG461 | |
| X | SER475 | |
| X | SER566 | |
| X | ASN567 | |
| X | GLY591 | |
| Y | ARG461 | |
| Y | SER475 | |
| Y | SER566 | |
| Y | ASN567 | |
| Y | GLY591 | |
| Z | ARG461 | |
| Z | SER475 | |
| Z | SER566 | |
| Z | ASN567 | |
| Z | GLY591 | |
| AA | ARG461 | |
| AA | SER475 | |
| AA | SER566 | |
| AA | ASN567 | |
| AA | GLY591 | |
| CA | ARG461 | |
| CA | SER475 | |
| CA | SER566 | |
| CA | ASN567 | |
| CA | GLY591 | |
| DA | ARG461 | |
| DA | SER475 | |
| DA | SER566 | |
| DA | ASN567 | |
| DA | GLY591 | |
| EA | ARG461 | |
| EA | SER475 | |
| EA | SER566 | |
| EA | ASN567 | |
| EA | GLY591 | |
| FA | ARG461 | |
| FA | SER475 | |
| FA | SER566 | |
| FA | ASN567 | |
| FA | GLY591 | |
| GA | ARG461 | |
| GA | SER475 | |
| GA | SER566 | |
| GA | ASN567 | |
| GA | GLY591 | |
| HA | ARG461 | |
| HA | SER475 | |
| HA | SER566 | |
| HA | ASN567 | |
| HA | GLY591 | |
| IA | ARG461 | |
| IA | SER475 | |
| IA | SER566 | |
| IA | ASN567 | |
| IA | GLY591 | |
| JA | ARG461 | |
| JA | SER475 | |
| JA | SER566 | |
| JA | ASN567 | |
| JA | GLY591 | |
| KA | ARG461 | |
| KA | SER475 | |
| KA | SER566 | |
| KA | ASN567 | |
| KA | GLY591 | |
| LA | ARG461 | |
| LA | SER475 | |
| LA | SER566 | |
| LA | ASN567 | |
| LA | GLY591 | |
| MA | ARG461 | |
| MA | SER475 | |
| MA | SER566 | |
| MA | ASN567 | |
| MA | GLY591 | |
| NA | ARG461 | |
| NA | SER475 | |
| NA | SER566 | |
| NA | ASN567 | |
| NA | GLY591 | |
| OA | ARG461 | |
| OA | SER475 | |
| OA | SER566 | |
| OA | ASN567 | |
| OA | GLY591 | |
| PA | ARG461 | |
| PA | SER475 | |
| PA | SER566 | |
| PA | ASN567 | |
| PA | GLY591 | |
| QA | ARG461 | |
| QA | SER475 | |
| QA | SER566 | |
| QA | ASN567 | |
| QA | GLY591 | |
| RA | ARG461 | |
| RA | SER475 | |
| RA | SER566 | |
| RA | ASN567 | |
| RA | GLY591 | |
| SA | ARG461 | |
| SA | SER475 | |
| SA | SER566 | |
| SA | ASN567 | |
| SA | GLY591 | |
| TA | ARG461 | |
| TA | SER475 | |
| TA | SER566 | |
| TA | ASN567 | |
| TA | GLY591 | |
| UA | ARG461 | |
| UA | SER475 | |
| UA | SER566 | |
| UA | ASN567 | |
| UA | GLY591 | |
| VA | ARG461 | |
| VA | SER475 | |
| VA | SER566 | |
| VA | ASN567 | |
| VA | GLY591 | |
| WA | ARG461 | |
| WA | SER475 | |
| WA | SER566 | |
| WA | ASN567 | |
| WA | GLY591 | |
| XA | ARG461 | |
| XA | SER475 | |
| XA | SER566 | |
| XA | ASN567 | |
| XA | GLY591 | |
| YA | ARG461 | |
| YA | SER475 | |
| YA | SER566 | |
| YA | ASN567 | |
| YA | GLY591 | |
| ZA | ARG461 | |
| ZA | SER475 | |
| ZA | SER566 | |
| ZA | ASN567 | |
| ZA | GLY591 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER100 | |
| AB | SER100 | |
| A | SER100 | |
| BB | SER100 | |
| CB | SER100 | |
| DB | SER100 | |
| EB | SER100 | |
| FB | SER100 | |
| GB | SER100 | |
| HB | SER100 | |
| IB | SER100 | |
| C | SER100 | |
| D | SER100 | |
| E | SER100 | |
| F | SER100 | |
| G | SER100 | |
| H | SER100 | |
| I | SER100 | |
| J | SER100 | |
| K | SER100 | |
| L | SER100 | |
| M | SER100 | |
| N | SER100 | |
| O | SER100 | |
| P | SER100 | |
| Q | SER100 | |
| R | SER100 | |
| BA | SER100 | |
| S | SER100 | |
| T | SER100 | |
| V | SER100 | |
| W | SER100 | |
| X | SER100 | |
| Y | SER100 | |
| Z | SER100 | |
| AA | SER100 | |
| CA | SER100 | |
| DA | SER100 | |
| EA | SER100 | |
| FA | SER100 | |
| GA | SER100 | |
| HA | SER100 | |
| IA | SER100 | |
| JA | SER100 | |
| KA | SER100 | |
| LA | SER100 | |
| MA | SER100 | |
| NA | SER100 | |
| OA | SER100 | |
| PA | SER100 | |
| QA | SER100 | |
| RA | SER100 | |
| SA | SER100 | |
| TA | SER100 | |
| UA | SER100 | |
| VA | SER100 | |
| WA | SER100 | |
| XA | SER100 | |
| YA | SER100 | |
| ZA | SER100 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | MOD_RES: N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000269|PubMed:25525879 |
| Chain | Residue | Details |
| B | LYS132 | |
| AB | LYS132 | |
| A | LYS132 | |
| BB | LYS132 | |
| CB | LYS132 | |
| DB | LYS132 | |
| EB | LYS132 | |
| FB | LYS132 | |
| GB | LYS132 | |
| HB | LYS132 | |
| IB | LYS132 | |
| C | LYS132 | |
| D | LYS132 | |
| E | LYS132 | |
| F | LYS132 | |
| G | LYS132 | |
| H | LYS132 | |
| I | LYS132 | |
| J | LYS132 | |
| K | LYS132 | |
| L | LYS132 | |
| M | LYS132 | |
| N | LYS132 | |
| O | LYS132 | |
| P | LYS132 | |
| Q | LYS132 | |
| R | LYS132 | |
| BA | LYS132 | |
| S | LYS132 | |
| T | LYS132 | |
| V | LYS132 | |
| W | LYS132 | |
| X | LYS132 | |
| Y | LYS132 | |
| Z | LYS132 | |
| AA | LYS132 | |
| CA | LYS132 | |
| DA | LYS132 | |
| EA | LYS132 | |
| FA | LYS132 | |
| GA | LYS132 | |
| HA | LYS132 | |
| IA | LYS132 | |
| JA | LYS132 | |
| KA | LYS132 | |
| LA | LYS132 | |
| MA | LYS132 | |
| NA | LYS132 | |
| OA | LYS132 | |
| PA | LYS132 | |
| QA | LYS132 | |
| RA | LYS132 | |
| SA | LYS132 | |
| TA | LYS132 | |
| UA | LYS132 | |
| VA | LYS132 | |
| WA | LYS132 | |
| XA | LYS132 | |
| YA | LYS132 | |
| ZA | LYS132 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 60 |
| Details | MOD_RES: N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:17532006, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:25525879, ECO:0007744|PDB:1Y8N, ECO:0007744|PDB:1Y8O, ECO:0007744|PDB:1Y8P, ECO:0007744|PDB:2PNR, ECO:0007744|PDB:2Q8I |
| Chain | Residue | Details |
| B | LYS259 | |
| AB | LYS259 | |
| A | LYS259 | |
| BB | LYS259 | |
| CB | LYS259 | |
| DB | LYS259 | |
| EB | LYS259 | |
| FB | LYS259 | |
| GB | LYS259 | |
| HB | LYS259 | |
| IB | LYS259 | |
| C | LYS259 | |
| D | LYS259 | |
| E | LYS259 | |
| F | LYS259 | |
| G | LYS259 | |
| H | LYS259 | |
| I | LYS259 | |
| J | LYS259 | |
| K | LYS259 | |
| L | LYS259 | |
| M | LYS259 | |
| N | LYS259 | |
| O | LYS259 | |
| P | LYS259 | |
| Q | LYS259 | |
| R | LYS259 | |
| BA | LYS259 | |
| S | LYS259 | |
| T | LYS259 | |
| V | LYS259 | |
| W | LYS259 | |
| X | LYS259 | |
| Y | LYS259 | |
| Z | LYS259 | |
| AA | LYS259 | |
| CA | LYS259 | |
| DA | LYS259 | |
| EA | LYS259 | |
| FA | LYS259 | |
| GA | LYS259 | |
| HA | LYS259 | |
| IA | LYS259 | |
| JA | LYS259 | |
| KA | LYS259 | |
| LA | LYS259 | |
| MA | LYS259 | |
| NA | LYS259 | |
| OA | LYS259 | |
| PA | LYS259 | |
| QA | LYS259 | |
| RA | LYS259 | |
| SA | LYS259 | |
| TA | LYS259 | |
| UA | LYS259 | |
| VA | LYS259 | |
| WA | LYS259 | |
| XA | LYS259 | |
| YA | LYS259 | |
| ZA | LYS259 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 60 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| B | LYS466 | |
| AB | LYS466 | |
| A | LYS466 | |
| BB | LYS466 | |
| CB | LYS466 | |
| DB | LYS466 | |
| EB | LYS466 | |
| FB | LYS466 | |
| GB | LYS466 | |
| HB | LYS466 | |
| IB | LYS466 | |
| C | LYS466 | |
| D | LYS466 | |
| E | LYS466 | |
| F | LYS466 | |
| G | LYS466 | |
| H | LYS466 | |
| I | LYS466 | |
| J | LYS466 | |
| K | LYS466 | |
| L | LYS466 | |
| M | LYS466 | |
| N | LYS466 | |
| O | LYS466 | |
| P | LYS466 | |
| Q | LYS466 | |
| R | LYS466 | |
| BA | LYS466 | |
| S | LYS466 | |
| T | LYS466 | |
| V | LYS466 | |
| W | LYS466 | |
| X | LYS466 | |
| Y | LYS466 | |
| Z | LYS466 | |
| AA | LYS466 | |
| CA | LYS466 | |
| DA | LYS466 | |
| EA | LYS466 | |
| FA | LYS466 | |
| GA | LYS466 | |
| HA | LYS466 | |
| IA | LYS466 | |
| JA | LYS466 | |
| KA | LYS466 | |
| LA | LYS466 | |
| MA | LYS466 | |
| NA | LYS466 | |
| OA | LYS466 | |
| PA | LYS466 | |
| QA | LYS466 | |
| RA | LYS466 | |
| SA | LYS466 | |
| TA | LYS466 | |
| UA | LYS466 | |
| VA | LYS466 | |
| WA | LYS466 | |
| XA | LYS466 | |
| YA | LYS466 | |
| ZA | LYS466 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 120 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BMF4 |
| Chain | Residue | Details |
| B | LYS473 | |
| B | LYS547 | |
| AB | LYS473 | |
| AB | LYS547 | |
| A | LYS473 | |
| A | LYS547 | |
| BB | LYS473 | |
| BB | LYS547 | |
| CB | LYS473 | |
| CB | LYS547 | |
| DB | LYS473 | |
| DB | LYS547 | |
| EB | LYS473 | |
| EB | LYS547 | |
| FB | LYS473 | |
| FB | LYS547 | |
| GB | LYS473 | |
| GB | LYS547 | |
| HB | LYS473 | |
| HB | LYS547 | |
| IB | LYS473 | |
| IB | LYS547 | |
| C | LYS473 | |
| C | LYS547 | |
| D | LYS473 | |
| D | LYS547 | |
| E | LYS473 | |
| E | LYS547 | |
| F | LYS473 | |
| F | LYS547 | |
| G | LYS473 | |
| G | LYS547 | |
| H | LYS473 | |
| H | LYS547 | |
| I | LYS473 | |
| I | LYS547 | |
| J | LYS473 | |
| J | LYS547 | |
| K | LYS473 | |
| K | LYS547 | |
| L | LYS473 | |
| L | LYS547 | |
| M | LYS473 | |
| M | LYS547 | |
| N | LYS473 | |
| N | LYS547 | |
| O | LYS473 | |
| O | LYS547 | |
| P | LYS473 | |
| P | LYS547 | |
| Q | LYS473 | |
| Q | LYS547 | |
| R | LYS473 | |
| R | LYS547 | |
| BA | LYS473 | |
| BA | LYS547 | |
| S | LYS473 | |
| S | LYS547 | |
| T | LYS473 | |
| T | LYS547 | |
| V | LYS473 | |
| V | LYS547 | |
| W | LYS473 | |
| W | LYS547 | |
| X | LYS473 | |
| X | LYS547 | |
| Y | LYS473 | |
| Y | LYS547 | |
| Z | LYS473 | |
| Z | LYS547 | |
| AA | LYS473 | |
| AA | LYS547 | |
| CA | LYS473 | |
| CA | LYS547 | |
| DA | LYS473 | |
| DA | LYS547 | |
| EA | LYS473 | |
| EA | LYS547 | |
| FA | LYS473 | |
| FA | LYS547 | |
| GA | LYS473 | |
| GA | LYS547 | |
| HA | LYS473 | |
| HA | LYS547 | |
| IA | LYS473 | |
| IA | LYS547 | |
| JA | LYS473 | |
| JA | LYS547 | |
| KA | LYS473 | |
| KA | LYS547 | |
| LA | LYS473 | |
| LA | LYS547 | |
| MA | LYS473 | |
| MA | LYS547 | |
| NA | LYS473 | |
| NA | LYS547 | |
| OA | LYS473 | |
| OA | LYS547 | |
| PA | LYS473 | |
| PA | LYS547 | |
| QA | LYS473 | |
| QA | LYS547 | |
| RA | LYS473 | |
| RA | LYS547 | |
| SA | LYS473 | |
| SA | LYS547 | |
| TA | LYS473 | |
| TA | LYS547 | |
| UA | LYS473 | |
| UA | LYS547 | |
| VA | LYS473 | |
| VA | LYS547 | |
| WA | LYS473 | |
| WA | LYS547 | |
| XA | LYS473 | |
| XA | LYS547 | |
| YA | LYS473 | |
| YA | LYS547 | |
| ZA | LYS473 | |
| ZA | LYS547 |
