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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8PIU

60-meric complex of dihydrolipoamide acetyltransferase (E2) of the human pyruvate dehydrogenase complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
A0006086biological_processpyruvate decarboxylation to acetyl-CoA
A0006090biological_processpyruvate metabolic process
A0016746molecular_functionacyltransferase activity
A0045254cellular_componentpyruvate dehydrogenase complex
AA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
AA0006086biological_processpyruvate decarboxylation to acetyl-CoA
AA0006090biological_processpyruvate metabolic process
AA0016746molecular_functionacyltransferase activity
AA0045254cellular_componentpyruvate dehydrogenase complex
AB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
AB0006086biological_processpyruvate decarboxylation to acetyl-CoA
AB0006090biological_processpyruvate metabolic process
AB0016746molecular_functionacyltransferase activity
AB0045254cellular_componentpyruvate dehydrogenase complex
B0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
B0006086biological_processpyruvate decarboxylation to acetyl-CoA
B0006090biological_processpyruvate metabolic process
B0016746molecular_functionacyltransferase activity
B0045254cellular_componentpyruvate dehydrogenase complex
BA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
BA0006086biological_processpyruvate decarboxylation to acetyl-CoA
BA0006090biological_processpyruvate metabolic process
BA0016746molecular_functionacyltransferase activity
BA0045254cellular_componentpyruvate dehydrogenase complex
BB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
BB0006086biological_processpyruvate decarboxylation to acetyl-CoA
BB0006090biological_processpyruvate metabolic process
BB0016746molecular_functionacyltransferase activity
BB0045254cellular_componentpyruvate dehydrogenase complex
C0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
C0006086biological_processpyruvate decarboxylation to acetyl-CoA
C0006090biological_processpyruvate metabolic process
C0016746molecular_functionacyltransferase activity
C0045254cellular_componentpyruvate dehydrogenase complex
CA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
CA0006086biological_processpyruvate decarboxylation to acetyl-CoA
CA0006090biological_processpyruvate metabolic process
CA0016746molecular_functionacyltransferase activity
CA0045254cellular_componentpyruvate dehydrogenase complex
CB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
CB0006086biological_processpyruvate decarboxylation to acetyl-CoA
CB0006090biological_processpyruvate metabolic process
CB0016746molecular_functionacyltransferase activity
CB0045254cellular_componentpyruvate dehydrogenase complex
D0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
D0006086biological_processpyruvate decarboxylation to acetyl-CoA
D0006090biological_processpyruvate metabolic process
D0016746molecular_functionacyltransferase activity
D0045254cellular_componentpyruvate dehydrogenase complex
DA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
DA0006086biological_processpyruvate decarboxylation to acetyl-CoA
DA0006090biological_processpyruvate metabolic process
DA0016746molecular_functionacyltransferase activity
DA0045254cellular_componentpyruvate dehydrogenase complex
DB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
DB0006086biological_processpyruvate decarboxylation to acetyl-CoA
DB0006090biological_processpyruvate metabolic process
DB0016746molecular_functionacyltransferase activity
DB0045254cellular_componentpyruvate dehydrogenase complex
E0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
E0006086biological_processpyruvate decarboxylation to acetyl-CoA
E0006090biological_processpyruvate metabolic process
E0016746molecular_functionacyltransferase activity
E0045254cellular_componentpyruvate dehydrogenase complex
EA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
EA0006086biological_processpyruvate decarboxylation to acetyl-CoA
EA0006090biological_processpyruvate metabolic process
EA0016746molecular_functionacyltransferase activity
EA0045254cellular_componentpyruvate dehydrogenase complex
EB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
EB0006086biological_processpyruvate decarboxylation to acetyl-CoA
EB0006090biological_processpyruvate metabolic process
EB0016746molecular_functionacyltransferase activity
EB0045254cellular_componentpyruvate dehydrogenase complex
F0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
F0006086biological_processpyruvate decarboxylation to acetyl-CoA
F0006090biological_processpyruvate metabolic process
F0016746molecular_functionacyltransferase activity
F0045254cellular_componentpyruvate dehydrogenase complex
FA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
FA0006086biological_processpyruvate decarboxylation to acetyl-CoA
FA0006090biological_processpyruvate metabolic process
FA0016746molecular_functionacyltransferase activity
FA0045254cellular_componentpyruvate dehydrogenase complex
FB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
FB0006086biological_processpyruvate decarboxylation to acetyl-CoA
FB0006090biological_processpyruvate metabolic process
FB0016746molecular_functionacyltransferase activity
FB0045254cellular_componentpyruvate dehydrogenase complex
G0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
G0006086biological_processpyruvate decarboxylation to acetyl-CoA
G0006090biological_processpyruvate metabolic process
G0016746molecular_functionacyltransferase activity
G0045254cellular_componentpyruvate dehydrogenase complex
GA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
GA0006086biological_processpyruvate decarboxylation to acetyl-CoA
GA0006090biological_processpyruvate metabolic process
GA0016746molecular_functionacyltransferase activity
GA0045254cellular_componentpyruvate dehydrogenase complex
GB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
GB0006086biological_processpyruvate decarboxylation to acetyl-CoA
GB0006090biological_processpyruvate metabolic process
GB0016746molecular_functionacyltransferase activity
GB0045254cellular_componentpyruvate dehydrogenase complex
H0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
H0006086biological_processpyruvate decarboxylation to acetyl-CoA
H0006090biological_processpyruvate metabolic process
H0016746molecular_functionacyltransferase activity
H0045254cellular_componentpyruvate dehydrogenase complex
HA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
HA0006086biological_processpyruvate decarboxylation to acetyl-CoA
HA0006090biological_processpyruvate metabolic process
HA0016746molecular_functionacyltransferase activity
HA0045254cellular_componentpyruvate dehydrogenase complex
HB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
HB0006086biological_processpyruvate decarboxylation to acetyl-CoA
HB0006090biological_processpyruvate metabolic process
HB0016746molecular_functionacyltransferase activity
HB0045254cellular_componentpyruvate dehydrogenase complex
I0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
I0006086biological_processpyruvate decarboxylation to acetyl-CoA
I0006090biological_processpyruvate metabolic process
I0016746molecular_functionacyltransferase activity
I0045254cellular_componentpyruvate dehydrogenase complex
IA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
IA0006086biological_processpyruvate decarboxylation to acetyl-CoA
IA0006090biological_processpyruvate metabolic process
IA0016746molecular_functionacyltransferase activity
IA0045254cellular_componentpyruvate dehydrogenase complex
IB0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
IB0006086biological_processpyruvate decarboxylation to acetyl-CoA
IB0006090biological_processpyruvate metabolic process
IB0016746molecular_functionacyltransferase activity
IB0045254cellular_componentpyruvate dehydrogenase complex
J0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
J0006086biological_processpyruvate decarboxylation to acetyl-CoA
J0006090biological_processpyruvate metabolic process
J0016746molecular_functionacyltransferase activity
J0045254cellular_componentpyruvate dehydrogenase complex
JA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
JA0006086biological_processpyruvate decarboxylation to acetyl-CoA
JA0006090biological_processpyruvate metabolic process
JA0016746molecular_functionacyltransferase activity
JA0045254cellular_componentpyruvate dehydrogenase complex
K0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
K0006086biological_processpyruvate decarboxylation to acetyl-CoA
K0006090biological_processpyruvate metabolic process
K0016746molecular_functionacyltransferase activity
K0045254cellular_componentpyruvate dehydrogenase complex
KA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
KA0006086biological_processpyruvate decarboxylation to acetyl-CoA
KA0006090biological_processpyruvate metabolic process
KA0016746molecular_functionacyltransferase activity
KA0045254cellular_componentpyruvate dehydrogenase complex
L0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
L0006086biological_processpyruvate decarboxylation to acetyl-CoA
L0006090biological_processpyruvate metabolic process
L0016746molecular_functionacyltransferase activity
L0045254cellular_componentpyruvate dehydrogenase complex
LA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
LA0006086biological_processpyruvate decarboxylation to acetyl-CoA
LA0006090biological_processpyruvate metabolic process
LA0016746molecular_functionacyltransferase activity
LA0045254cellular_componentpyruvate dehydrogenase complex
M0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
M0006086biological_processpyruvate decarboxylation to acetyl-CoA
M0006090biological_processpyruvate metabolic process
M0016746molecular_functionacyltransferase activity
M0045254cellular_componentpyruvate dehydrogenase complex
MA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
MA0006086biological_processpyruvate decarboxylation to acetyl-CoA
MA0006090biological_processpyruvate metabolic process
MA0016746molecular_functionacyltransferase activity
MA0045254cellular_componentpyruvate dehydrogenase complex
N0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
N0006086biological_processpyruvate decarboxylation to acetyl-CoA
N0006090biological_processpyruvate metabolic process
N0016746molecular_functionacyltransferase activity
N0045254cellular_componentpyruvate dehydrogenase complex
NA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
NA0006086biological_processpyruvate decarboxylation to acetyl-CoA
NA0006090biological_processpyruvate metabolic process
NA0016746molecular_functionacyltransferase activity
NA0045254cellular_componentpyruvate dehydrogenase complex
O0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
O0006086biological_processpyruvate decarboxylation to acetyl-CoA
O0006090biological_processpyruvate metabolic process
O0016746molecular_functionacyltransferase activity
O0045254cellular_componentpyruvate dehydrogenase complex
OA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
OA0006086biological_processpyruvate decarboxylation to acetyl-CoA
OA0006090biological_processpyruvate metabolic process
OA0016746molecular_functionacyltransferase activity
OA0045254cellular_componentpyruvate dehydrogenase complex
P0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
P0006086biological_processpyruvate decarboxylation to acetyl-CoA
P0006090biological_processpyruvate metabolic process
P0016746molecular_functionacyltransferase activity
P0045254cellular_componentpyruvate dehydrogenase complex
PA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
PA0006086biological_processpyruvate decarboxylation to acetyl-CoA
PA0006090biological_processpyruvate metabolic process
PA0016746molecular_functionacyltransferase activity
PA0045254cellular_componentpyruvate dehydrogenase complex
Q0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
Q0006086biological_processpyruvate decarboxylation to acetyl-CoA
Q0006090biological_processpyruvate metabolic process
Q0016746molecular_functionacyltransferase activity
Q0045254cellular_componentpyruvate dehydrogenase complex
QA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
QA0006086biological_processpyruvate decarboxylation to acetyl-CoA
QA0006090biological_processpyruvate metabolic process
QA0016746molecular_functionacyltransferase activity
QA0045254cellular_componentpyruvate dehydrogenase complex
R0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
R0006086biological_processpyruvate decarboxylation to acetyl-CoA
R0006090biological_processpyruvate metabolic process
R0016746molecular_functionacyltransferase activity
R0045254cellular_componentpyruvate dehydrogenase complex
RA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
RA0006086biological_processpyruvate decarboxylation to acetyl-CoA
RA0006090biological_processpyruvate metabolic process
RA0016746molecular_functionacyltransferase activity
RA0045254cellular_componentpyruvate dehydrogenase complex
S0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
S0006086biological_processpyruvate decarboxylation to acetyl-CoA
S0006090biological_processpyruvate metabolic process
S0016746molecular_functionacyltransferase activity
S0045254cellular_componentpyruvate dehydrogenase complex
SA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
SA0006086biological_processpyruvate decarboxylation to acetyl-CoA
SA0006090biological_processpyruvate metabolic process
SA0016746molecular_functionacyltransferase activity
SA0045254cellular_componentpyruvate dehydrogenase complex
T0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
T0006086biological_processpyruvate decarboxylation to acetyl-CoA
T0006090biological_processpyruvate metabolic process
T0016746molecular_functionacyltransferase activity
T0045254cellular_componentpyruvate dehydrogenase complex
TA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
TA0006086biological_processpyruvate decarboxylation to acetyl-CoA
TA0006090biological_processpyruvate metabolic process
TA0016746molecular_functionacyltransferase activity
TA0045254cellular_componentpyruvate dehydrogenase complex
UA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
UA0006086biological_processpyruvate decarboxylation to acetyl-CoA
UA0006090biological_processpyruvate metabolic process
UA0016746molecular_functionacyltransferase activity
UA0045254cellular_componentpyruvate dehydrogenase complex
V0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
V0006086biological_processpyruvate decarboxylation to acetyl-CoA
V0006090biological_processpyruvate metabolic process
V0016746molecular_functionacyltransferase activity
V0045254cellular_componentpyruvate dehydrogenase complex
VA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
VA0006086biological_processpyruvate decarboxylation to acetyl-CoA
VA0006090biological_processpyruvate metabolic process
VA0016746molecular_functionacyltransferase activity
VA0045254cellular_componentpyruvate dehydrogenase complex
W0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
W0006086biological_processpyruvate decarboxylation to acetyl-CoA
W0006090biological_processpyruvate metabolic process
W0016746molecular_functionacyltransferase activity
W0045254cellular_componentpyruvate dehydrogenase complex
WA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
WA0006086biological_processpyruvate decarboxylation to acetyl-CoA
WA0006090biological_processpyruvate metabolic process
WA0016746molecular_functionacyltransferase activity
WA0045254cellular_componentpyruvate dehydrogenase complex
X0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
X0006086biological_processpyruvate decarboxylation to acetyl-CoA
X0006090biological_processpyruvate metabolic process
X0016746molecular_functionacyltransferase activity
X0045254cellular_componentpyruvate dehydrogenase complex
XA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
XA0006086biological_processpyruvate decarboxylation to acetyl-CoA
XA0006090biological_processpyruvate metabolic process
XA0016746molecular_functionacyltransferase activity
XA0045254cellular_componentpyruvate dehydrogenase complex
Y0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
Y0006086biological_processpyruvate decarboxylation to acetyl-CoA
Y0006090biological_processpyruvate metabolic process
Y0016746molecular_functionacyltransferase activity
Y0045254cellular_componentpyruvate dehydrogenase complex
YA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
YA0006086biological_processpyruvate decarboxylation to acetyl-CoA
YA0006090biological_processpyruvate metabolic process
YA0016746molecular_functionacyltransferase activity
YA0045254cellular_componentpyruvate dehydrogenase complex
Z0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
Z0006086biological_processpyruvate decarboxylation to acetyl-CoA
Z0006090biological_processpyruvate metabolic process
Z0016746molecular_functionacyltransferase activity
Z0045254cellular_componentpyruvate dehydrogenase complex
ZA0004742molecular_functiondihydrolipoyllysine-residue acetyltransferase activity
ZA0006086biological_processpyruvate decarboxylation to acetyl-CoA
ZA0006090biological_processpyruvate metabolic process
ZA0016746molecular_functionacyltransferase activity
ZA0045254cellular_componentpyruvate dehydrogenase complex
Functional Information from PROSITE/UniProt
site_idPS00178
Number of Residues12
DetailsAA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PalSPtMTMGTV
ChainResidueDetails
BPRO224-VAL235
site_idPS00189
Number of Residues30
DetailsLIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdkInegDLIaeVETdKATvgFesleeCyM
ChainResidueDetails
BGLY116-MET145
BGLY243-LEU272
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues120
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"Q9N0F1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues300
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P11181","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues60
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues120
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BMF4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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