8PIS

Crystal structure of Ser33 in complex with L-Serine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004617	molecular_function	phosphoglycerate dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006564	biological_process	L-serine biosynthetic process
A	0006979	biological_process	response to oxidative stress
A	0009070	biological_process	serine family amino acid biosynthetic process
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042802	molecular_function	identical protein binding
A	0051287	molecular_function	NAD binding
A	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
A	1902494	cellular_component	catalytic complex
B	0004617	molecular_function	phosphoglycerate dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006564	biological_process	L-serine biosynthetic process
B	0006979	biological_process	response to oxidative stress
B	0009070	biological_process	serine family amino acid biosynthetic process
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0040029	biological_process	epigenetic regulation of gene expression
B	0042802	molecular_function	identical protein binding
B	0051287	molecular_function	NAD binding
B	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
B	1902494	cellular_component	catalytic complex
C	0004617	molecular_function	phosphoglycerate dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006564	biological_process	L-serine biosynthetic process
C	0006979	biological_process	response to oxidative stress
C	0009070	biological_process	serine family amino acid biosynthetic process
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0040029	biological_process	epigenetic regulation of gene expression
C	0042802	molecular_function	identical protein binding
C	0051287	molecular_function	NAD binding
C	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
C	1902494	cellular_component	catalytic complex
D	0004617	molecular_function	phosphoglycerate dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006564	biological_process	L-serine biosynthetic process
D	0006979	biological_process	response to oxidative stress
D	0009070	biological_process	serine family amino acid biosynthetic process
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0040029	biological_process	epigenetic regulation of gene expression
D	0042802	molecular_function	identical protein binding
D	0051287	molecular_function	NAD binding
D	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
D	1902494	cellular_component	catalytic complex
E	0004617	molecular_function	phosphoglycerate dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006564	biological_process	L-serine biosynthetic process
E	0006979	biological_process	response to oxidative stress
E	0009070	biological_process	serine family amino acid biosynthetic process
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042802	molecular_function	identical protein binding
E	0051287	molecular_function	NAD binding
E	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
E	1902494	cellular_component	catalytic complex
F	0004617	molecular_function	phosphoglycerate dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006564	biological_process	L-serine biosynthetic process
F	0006979	biological_process	response to oxidative stress
F	0009070	biological_process	serine family amino acid biosynthetic process
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0040029	biological_process	epigenetic regulation of gene expression
F	0042802	molecular_function	identical protein binding
F	0051287	molecular_function	NAD binding
F	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
F	1902494	cellular_component	catalytic complex
G	0004617	molecular_function	phosphoglycerate dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006564	biological_process	L-serine biosynthetic process
G	0006979	biological_process	response to oxidative stress
G	0009070	biological_process	serine family amino acid biosynthetic process
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0040029	biological_process	epigenetic regulation of gene expression
G	0042802	molecular_function	identical protein binding
G	0051287	molecular_function	NAD binding
G	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
G	1902494	cellular_component	catalytic complex
H	0004617	molecular_function	phosphoglycerate dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006564	biological_process	L-serine biosynthetic process
H	0006979	biological_process	response to oxidative stress
H	0009070	biological_process	serine family amino acid biosynthetic process
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0040029	biological_process	epigenetic regulation of gene expression
H	0042802	molecular_function	identical protein binding
H	0051287	molecular_function	NAD binding
H	0120568	molecular_function	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
H	1902494	cellular_component	catalytic complex

Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	28
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGyGHIGsqlsvlaeamglh.VLyYD

Chain	Residue	Details
A	LEU201-ASP228

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site_id	PS00670
Number of Residues	23
Details	D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. LLnkSDFVtLHvPatpeTekMlS

Chain	Residue	Details
A	LEU247-SER269

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site_id	PS00671
Number of Residues	17
Details	D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKdGaYVINaSRGtVVD

Chain	Residue	Details
A	MET276-ASP292

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	Domain: {"description":"ACT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A9T0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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