8PIA

DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>T)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001889	biological_process	liver development
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0030073	biological_process	insulin secretion
A	0031016	biological_process	pancreas development
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0001889	biological_process	liver development
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0030073	biological_process	insulin secretion
B	0031016	biological_process	pancreas development
B	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. GLgsNlVTevRVYNWFaNrrkeeA

Chain	Residue	Details
A	GLY253-ALA276

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	DNA_BIND: Homeobox; HNF1-type => ECO:0000255|PROSITE-ProRule:PRU00108

Chain	Residue	Details
A	GLY199-HIS279
B	GLY199-HIS279

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER93
A	SER247
B	SER93
B	SER247

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:38018242

Chain	Residue	Details
A	LYS117
B	LYS117

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