8PF3

Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 1-(3,4-dichlorobenzyl)-4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-(3-phenylpropyl)piperazin-1-ium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0015042	molecular_function	trypanothione-disulfide reductase (NADPH) activity
A	0016491	molecular_function	oxidoreductase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0045454	biological_process	cell redox homeostasis
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000166	molecular_function	nucleotide binding
B	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0015042	molecular_function	trypanothione-disulfide reductase (NADPH) activity
B	0016491	molecular_function	oxidoreductase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0045454	biological_process	cell redox homeostasis
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0098869	biological_process	cellular oxidant detoxification
C	0000166	molecular_function	nucleotide binding
C	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006749	biological_process	glutathione metabolic process
C	0015042	molecular_function	trypanothione-disulfide reductase (NADPH) activity
C	0016491	molecular_function	oxidoreductase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0045454	biological_process	cell redox homeostasis
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0098869	biological_process	cellular oxidant detoxification
D	0000166	molecular_function	nucleotide binding
D	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006749	biological_process	glutathione metabolic process
D	0015042	molecular_function	trypanothione-disulfide reductase (NADPH) activity
D	0016491	molecular_function	oxidoreductase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0045454	biological_process	cell redox homeostasis
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP

Chain	Residue	Details
A	GLY49-PRO59

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