8PEM
Zika Methyltransferase in complex with AT-9010 and SAH
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
| Chain | Residue | Details |
| A | LYS67 | |
| A | ASP152 | |
| A | LYS188 | |
| A | GLU224 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS19 | |
| A | ARG219 | |
| A | SER221 | |
| A | TYR226 | |
| A | LEU22 | |
| A | ASN23 | |
| A | MET25 | |
| A | PHE30 | |
| A | LYS34 | |
| A | THR110 | |
| A | ILE153 | |
| A | SER156 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345656 |
| Chain | Residue | Details |
| A | SER62 | |
| A | ASP137 | |
| A | VAL138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:28291746 |
| Chain | Residue | Details |
| A | GLY92 | |
| A | TRP93 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27386922, ECO:0000269|PubMed:27399257, ECO:0000269|PubMed:29080786 |
| Chain | Residue | Details |
| A | LYS111 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28345656 |
| Chain | Residue | Details |
| A | HIS116 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:A0A024B7W1 |
| Chain | Residue | Details |
| A | GLU117 | |
| A | GLU155 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28291746, ECO:0000269|PubMed:28345656 |
| Chain | Residue | Details |
| A | ASP152 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS67 | |
| A | LYS188 | |
| A | GLU224 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | ASP152 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
| Chain | Residue | Details |
| A | SER62 |
