8PD9
cAMP-bound SpSLC9C1 in lipid nanodiscs, protomer state 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 110 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | SER30-LYS76 | |
| A | VAL120-PRO135 | |
| A | PHE189-ASN194 | |
| A | LYS250-THR260 | |
| A | GLU320-SER322 | |
| A | VAL378-LYS382 | |
| A | GLY447-VAL450 | |
| A | SER709-SER724 | |
| A | LEU785-SER795 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | VAL77-LYS96 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 733 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | LYS97-PRO101 | |
| A | ALA153-SER162 | |
| A | GLY221-SER223 | |
| A | ILE293-ASP296 | |
| A | GLU337-PRO343 | |
| A | ILE413-THR418 | |
| A | GLY482-HIS677 | |
| A | GLY753-VAL760 | |
| A | LEU823-VAL1325 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | TYR102-ASN119 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | HIS136-PHE152 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | PHE163-LEU188 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM5 => ECO:0000269|PubMed:37880360, ECO:0000305|PubMed:37880361 |
| Chain | Residue | Details |
| A | PHE195-LEU220 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=TM6 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | LYS224-MET249 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 31 |
| Details | TRANSMEM: Helical; Name=TM7, linker => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | VAL261-HIS292 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=TM8 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | ALA297-LEU319 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 13 |
| Details | TRANSMEM: Helical; Name=TM9 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | GLY323-ALA336 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 33 |
| Details | TRANSMEM: Helical; Name=TM10 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | GLU344-LEU377 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=TM11 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | MET383-ARG412 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=TM12 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | TRP419-ALA446 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=TM13 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | ILE451-LEU481 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | MET678-VAL708 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | LEU725-LEU752 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | SER761-LEU784 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:37880361 |
| Chain | Residue | Details |
| A | ILE796-ILE822 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37880360 |
| Chain | Residue | Details |
| A | HIS73 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PDV |
| Chain | Residue | Details |
| A | GLY1043 | |
| A | GLU1044 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PDU |
| Chain | Residue | Details |
| A | MET1045 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PD9 |
| Chain | Residue | Details |
| A | GLY1046 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PDU, ECO:0007744|PDB:8PDV |
| Chain | Residue | Details |
| A | ARG1053 | |
| A | ASN1054 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | SITE: Contributes one equivalent gating charge => ECO:0000269|PubMed:30022052 |
| Chain | Residue | Details |
| A | ARG803 |
