Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8PCZ

Ligand-free SpSLC9C1 in lipid nanodiscs, dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006812	biological_process	monoatomic cation transport
A	0015297	molecular_function	antiporter activity
A	0015385	molecular_function	sodium:proton antiporter activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	1902600	biological_process	proton transmembrane transport
B	0006812	biological_process	monoatomic cation transport
B	0015297	molecular_function	antiporter activity
B	0015385	molecular_function	sodium:proton antiporter activity
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
B	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	72
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	78
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=TM7, linker","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	58
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=TM13","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	370
Details	Region: {"description":"Transport core domain","evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	208
Details	Region: {"description":"Interacts with the S4 segment of voltage sensor domain","evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	30
Details	Region: {"description":"Interacts with the transport core domain; can lock the transporter in the inward conformation","evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	122
Details	Region: {"description":"S4 segment of voltage sensor domain","evidences":[{"source":"PubMed","id":"30022052","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Motif: {"description":"Essential for sodium:proton exchange","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30022052","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37880360","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PDV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PDU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PD9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37880361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PDV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	2
Details	Site: {"description":"Contributes one equivalent gating charge","evidences":[{"source":"PubMed","id":"30022052","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)