8PBQ

Mutant R1810Q of the dihydroorotase domain of human CAD protein bound to the substrates

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Functional Information from PROSITE/UniProt

site_id	PS00482
Number of Residues	9
Details	DIHYDROOROTASE_1 Dihydroorotase signature 1. DVHVHLReP

Chain	Residue	Details
A	ASP1469-PRO1477

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site_id	PS00483
Number of Residues	12
Details	DIHYDROOROTASE_2 Dihydroorotase signature 2. ASDhAPHtleeK

Chain	Residue	Details
A	ALA1684-LYS1695

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For DHOase activity => ECO:0000250|UniProtKB:P05020

Chain	Residue	Details
A	ASP1686

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D

Chain	Residue	Details
A	HIS1471
A	HIS1473
A	HIS1590
A	CYS1613
A	HIS1614
A	GLU1637
A	ASP1686

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6Q

Chain	Residue	Details
A	ARG1475
A	ASN1505
A	ARG1661
A	HIS1690
A	PRO1702

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: via carbamate group => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D

Chain	Residue	Details
A	KCX1556

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:24332717

Chain	Residue	Details
A	KCX1556

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