8P7D

CryoEM structure of METTL6 tRNA SerRS complex in a 1:1:2 stoichiometry

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006400	biological_process	tRNA modification
A	0008033	biological_process	tRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0019899	molecular_function	enzyme binding
A	0030488	biological_process	tRNA methylation
A	0032259	biological_process	methylation
A	0052735	molecular_function	tRNA (cytidine-3-)-methyltransferase activity
B	0000049	molecular_function	tRNA binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000166	molecular_function	nucleotide binding
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0001514	biological_process	selenocysteine incorporation
B	0002181	biological_process	cytoplasmic translation
B	0003677	molecular_function	DNA binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004828	molecular_function	serine-tRNA ligase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006400	biological_process	tRNA modification
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006434	biological_process	seryl-tRNA aminoacylation
B	0016525	biological_process	negative regulation of angiogenesis
B	0016874	molecular_function	ligase activity
B	0019899	molecular_function	enzyme binding
B	0042803	molecular_function	protein homodimerization activity
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
B	0098619	molecular_function	selenocysteine-tRNA ligase activity
B	1904046	biological_process	negative regulation of vascular endothelial growth factor production
D	0000049	molecular_function	tRNA binding
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000166	molecular_function	nucleotide binding
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0001514	biological_process	selenocysteine incorporation
D	0002181	biological_process	cytoplasmic translation
D	0003677	molecular_function	DNA binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004828	molecular_function	serine-tRNA ligase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006400	biological_process	tRNA modification
D	0006412	biological_process	translation
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006434	biological_process	seryl-tRNA aminoacylation
D	0016525	biological_process	negative regulation of angiogenesis
D	0016874	molecular_function	ligase activity
D	0019899	molecular_function	enzyme binding
D	0042803	molecular_function	protein homodimerization activity
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome
D	0098619	molecular_function	selenocysteine-tRNA ligase activity
D	1904046	biological_process	negative regulation of vascular endothelial growth factor production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34922197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F1E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34862464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EZG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Region: {"description":"Interaction with tRNA","evidences":[{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Important for serine binding","evidences":[{"source":"PubMed","id":"28236339","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---