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8P6V

Cryo-EM structure of CAK in complex with inhibitor ICEC0942

Functional Information from GO Data
ChainGOidnamespacecontents
I0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
I0000439cellular_componenttranscription factor TFIIH core complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005675cellular_componenttranscription factor TFIIH holo complex
I0006351biological_processDNA-templated transcription
I0006357biological_processregulation of transcription by RNA polymerase II
I0006367biological_processtranscription initiation at RNA polymerase II promoter
I0016251molecular_functionRNA polymerase II general transcription initiation factor activity
I0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
I0050821biological_processprotein stabilization
I0070516cellular_componentCAK-ERCC2 complex
I0070985cellular_componenttranscription factor TFIIK complex
I2000045biological_processregulation of G1/S transition of mitotic cell cycle
J0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
J0000439cellular_componenttranscription factor TFIIH core complex
J0001650cellular_componentfibrillar center
J0001673cellular_componentmale germ cell nucleus
J0004672molecular_functionprotein kinase activity
J0004674molecular_functionprotein serine/threonine kinase activity
J0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005675cellular_componenttranscription factor TFIIH holo complex
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006281biological_processDNA repair
J0006366biological_processtranscription by RNA polymerase II
J0006367biological_processtranscription initiation at RNA polymerase II promoter
J0006468biological_processprotein phosphorylation
J0008094molecular_functionATP-dependent activity, acting on DNA
J0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
J0016301molecular_functionkinase activity
J0042795biological_processsnRNA transcription by RNA polymerase II
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0048471cellular_componentperinuclear region of cytoplasm
J0050821biological_processprotein stabilization
J0051301biological_processcell division
J0051726biological_processregulation of cell cycle
J0070516cellular_componentCAK-ERCC2 complex
J0070985cellular_componenttranscription factor TFIIK complex
J0106310molecular_functionprotein serine kinase activity
J0140833molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 kinase activity
J0140834molecular_functionRNA polymerase II CTD heptapeptide repeat S2 kinase activity
J0140835molecular_functionRNA polymerase II CTD heptapeptide repeat T4 kinase activity
J0140836molecular_functionRNA polymerase II CTD heptapeptide repeat S5 kinase activity
J0140837molecular_functionRNA polymerase II CTD heptapeptide repeat S7 kinase activity
J2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK
ChainResidueDetails
JLEU18-LYS42

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL
ChainResidueDetails
JILE133-LEU145

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:15530371
ChainResidueDetails
JASP137
ISER304

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:15530371
ChainResidueDetails
JLEU18
JLYS41

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
JALA2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976
ChainResidueDetails
JSER7

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 and CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163
ChainResidueDetails
JSER164

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
JTHR170

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231
ChainResidueDetails
JSER321

227344

PDB entries from 2024-11-13

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