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8P2Y

Structure of human SIT1:ACE2 complex (closed PD conformation)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001817biological_processregulation of cytokine production
A0002003biological_processangiotensin maturation
A0003051biological_processangiotensin-mediated drinking behavior
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0004175molecular_functionendopeptidase activity
A0004180molecular_functioncarboxypeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008241molecular_functionpeptidyl-dipeptidase activity
A0008270molecular_functionzinc ion binding
A0009986cellular_componentcell surface
A0015827biological_processtryptophan transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019058biological_processviral life cycle
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019229biological_processregulation of vasoconstriction
A0022898biological_processregulation of transmembrane transporter activity
A0030666cellular_componentendocytic vesicle membrane
A0031526cellular_componentbrush border membrane
A0042127biological_processregulation of cell population proliferation
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0045121cellular_componentmembrane raft
A0046718biological_processsymbiont entry into host cell
A0046813biological_processreceptor-mediated virion attachment to host cell
A0046872molecular_functionmetal ion binding
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050727biological_processregulation of inflammatory response
A0051957biological_processpositive regulation of amino acid transport
A0060135biological_processmaternal process involved in female pregnancy
A0060452biological_processpositive regulation of cardiac muscle contraction
A0061025biological_processmembrane fusion
A0070062cellular_componentextracellular exosome
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0097746biological_processblood vessel diameter maintenance
A0098670biological_processentry receptor-mediated virion attachment to host cell
A1903598biological_processpositive regulation of gap junction assembly
A1903779biological_processregulation of cardiac conduction
A1905737biological_processpositive regulation of L-proline import across plasma membrane
A2000272biological_processnegative regulation of signaling receptor activity
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0001618molecular_functionvirus receptor activity
B0001817biological_processregulation of cytokine production
B0002003biological_processangiotensin maturation
B0003051biological_processangiotensin-mediated drinking behavior
B0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
B0004175molecular_functionendopeptidase activity
B0004180molecular_functioncarboxypeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008241molecular_functionpeptidyl-dipeptidase activity
B0008270molecular_functionzinc ion binding
B0009986cellular_componentcell surface
B0015827biological_processtryptophan transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0019058biological_processviral life cycle
B0019065biological_processreceptor-mediated endocytosis of virus by host cell
B0019229biological_processregulation of vasoconstriction
B0022898biological_processregulation of transmembrane transporter activity
B0030666cellular_componentendocytic vesicle membrane
B0031526cellular_componentbrush border membrane
B0042127biological_processregulation of cell population proliferation
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0045121cellular_componentmembrane raft
B0046718biological_processsymbiont entry into host cell
B0046813biological_processreceptor-mediated virion attachment to host cell
B0046872molecular_functionmetal ion binding
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050727biological_processregulation of inflammatory response
B0051957biological_processpositive regulation of amino acid transport
B0060135biological_processmaternal process involved in female pregnancy
B0060452biological_processpositive regulation of cardiac muscle contraction
B0061025biological_processmembrane fusion
B0070062cellular_componentextracellular exosome
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0097746biological_processblood vessel diameter maintenance
B0098670biological_processentry receptor-mediated virion attachment to host cell
B1903598biological_processpositive regulation of gap junction assembly
B1903779biological_processregulation of cardiac conduction
B1905737biological_processpositive regulation of L-proline import across plasma membrane
B2000272biological_processnegative regulation of signaling receptor activity
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0005298molecular_functionproline:sodium symporter activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006865biological_processamino acid transport
C0015171molecular_functionamino acid transmembrane transporter activity
C0015175molecular_functionneutral L-amino acid transmembrane transporter activity
C0015188molecular_functionL-isoleucine transmembrane transporter activity
C0015193molecular_functionL-proline transmembrane transporter activity
C0015199molecular_functionamino-acid betaine transmembrane transporter activity
C0015293molecular_functionsymporter activity
C0015370molecular_functionsolute:sodium symporter activity
C0015816biological_processglycine transport
C0015824biological_processproline transport
C0015838biological_processamino-acid betaine transport
C0016324cellular_componentapical plasma membrane
C0022857molecular_functiontransmembrane transporter activity
C0035725biological_processsodium ion transmembrane transport
C0089718biological_processamino acid import across plasma membrane
C0150104biological_processtransport across blood-brain barrier
C1903804biological_processglycine import across plasma membrane
C1903806biological_processL-isoleucine import across plasma membrane
C1904271biological_processL-proline import across plasma membrane
C1905647biological_processproline import across plasma membrane
D0005298molecular_functionproline:sodium symporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006865biological_processamino acid transport
D0015171molecular_functionamino acid transmembrane transporter activity
D0015175molecular_functionneutral L-amino acid transmembrane transporter activity
D0015188molecular_functionL-isoleucine transmembrane transporter activity
D0015193molecular_functionL-proline transmembrane transporter activity
D0015199molecular_functionamino-acid betaine transmembrane transporter activity
D0015293molecular_functionsymporter activity
D0015370molecular_functionsolute:sodium symporter activity
D0015816biological_processglycine transport
D0015824biological_processproline transport
D0015838biological_processamino-acid betaine transport
D0016324cellular_componentapical plasma membrane
D0022857molecular_functiontransmembrane transporter activity
D0035725biological_processsodium ion transmembrane transport
D0089718biological_processamino acid import across plasma membrane
D0150104biological_processtransport across blood-brain barrier
D1903804biological_processglycine import across plasma membrane
D1903806biological_processL-isoleucine import across plasma membrane
D1904271biological_processL-proline import across plasma membrane
D1905647biological_processproline import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
ATHR371-GLN380

site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqmYGGGsF
ChainResidueDetails
CTRP29-PHE43

site_idPS00754
Number of Residues21
DetailsNA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfhSFQdpLPWsvCplngNH
ChainResidueDetails
CTYR112-HIS132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues184
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
CMET1-ARG5
DARG187-LYS194
DALA263-ALA276
DTHR411-GLU431
DARG487-TYR504
DGLY576-ALA592
CALA64-THR79
CARG187-LYS194
CALA263-ALA276
CTHR411-GLU431
CARG487-TYR504
CGLY576-ALA592
DMET1-ARG5
DALA64-THR79

site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
CPRO6-GLY26
DPRO6-GLY26

site_idSWS_FT_FI3
Number of Residues470
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
CASN27-SER42
DTYR298-GLN389
DGLY453-ALA465
DSER526-TYR554
CTYR101-GLY165
CTHR216-TRP241
CTYR298-GLN389
CGLY453-ALA465
CSER526-TYR554
DASN27-SER42
DTYR101-GLY165
DTHR216-TRP241

site_idSWS_FT_FI4
Number of Residues40
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
CPHE43-LEU63
DPHE43-LEU63

site_idSWS_FT_FI5
Number of Residues40
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
CILE80-MET100
DILE80-MET100

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
CVAL166-LEU186
DVAL166-LEU186
ALYS481
BARG169
BTRP477
BLYS481

site_idSWS_FT_FI7
Number of Residues40
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
CVAL195-LEU215
DVAL195-LEU215
ATYR515
BARG273
BHIS345
BTYR515

site_idSWS_FT_FI8
Number of Residues40
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
CILE242-PHE262
DILE242-PHE262
AGLU402
BHIS374
BHIS378
BGLU402

site_idSWS_FT_FI9
Number of Residues40
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
CILE277-ILE297
DILE277-ILE297

site_idSWS_FT_FI10
Number of Residues40
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255
ChainResidueDetails
CLEU390-ASN410
DLEU390-ASN410

site_idSWS_FT_FI11
Number of Residues40
DetailsTRANSMEM: Helical; Name=9 => ECO:0000255
ChainResidueDetails
CALA432-ALA452
DALA432-ALA452
BASN53
BASN322

site_idSWS_FT_FI12
Number of Residues40
DetailsTRANSMEM: Helical; Name=10 => ECO:0000255
ChainResidueDetails
CTHR466-LEU486
DTHR466-LEU486

site_idSWS_FT_FI13
Number of Residues40
DetailsTRANSMEM: Helical; Name=11 => ECO:0000255
ChainResidueDetails
CTRP505-LEU525
DTRP505-LEU525
BASN103
BASN432

site_idSWS_FT_FI14
Number of Residues40
DetailsTRANSMEM: Helical; Name=12 => ECO:0000255
ChainResidueDetails
CALA555-LEU575
DALA555-LEU575

site_idSWS_FT_FI15
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN131
CASN357
DASN131
DASN357

site_idSWS_FT_FI16
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523
ChainResidueDetails
ALYS788
BLYS788

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PDB entries from 2024-07-24

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