8OTX
Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in nanodisc
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006812 | biological_process | monoatomic cation transport |
A | 0015297 | molecular_function | antiporter activity |
A | 0015385 | molecular_function | sodium:proton antiporter activity |
A | 0016020 | cellular_component | membrane |
A | 0055085 | biological_process | transmembrane transport |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0006812 | biological_process | monoatomic cation transport |
B | 0015297 | molecular_function | antiporter activity |
B | 0015385 | molecular_function | sodium:proton antiporter activity |
B | 0016020 | cellular_component | membrane |
B | 0055085 | biological_process | transmembrane transport |
B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 220 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
B | SER30-LYS76 | |
A | SER30-LYS76 | |
A | VAL120-PRO135 | |
A | PHE189-ASN194 | |
A | LYS250-THR260 | |
A | GLU320-SER322 | |
A | VAL378-LYS382 | |
A | GLY447-VAL450 | |
A | SER709-SER724 | |
A | LEU785-SER795 | |
B | VAL120-PRO135 | |
B | PHE189-ASN194 | |
B | LYS250-THR260 | |
B | GLU320-SER322 | |
B | VAL378-LYS382 | |
B | GLY447-VAL450 | |
B | SER709-SER724 | |
B | LEU785-SER795 |
site_id | SWS_FT_FI2 |
Number of Residues | 38 |
Details | TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | VAL77-LYS96 | |
A | VAL77-LYS96 |
site_id | SWS_FT_FI3 |
Number of Residues | 1466 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
B | LYS97-PRO101 | |
A | LYS97-PRO101 | |
A | ALA153-SER162 | |
A | GLY221-SER223 | |
A | ILE293-ASP296 | |
A | GLU337-PRO343 | |
A | ILE413-THR418 | |
A | GLY482-HIS677 | |
A | GLY753-VAL760 | |
A | LEU823-VAL1325 | |
B | ALA153-SER162 | |
B | GLY221-SER223 | |
B | ILE293-ASP296 | |
B | GLU337-PRO343 | |
B | ILE413-THR418 | |
B | GLY482-HIS677 | |
B | GLY753-VAL760 | |
B | LEU823-VAL1325 |
site_id | SWS_FT_FI4 |
Number of Residues | 34 |
Details | TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | TYR102-ASN119 | |
A | TYR102-ASN119 |
site_id | SWS_FT_FI5 |
Number of Residues | 32 |
Details | TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | HIS136-PHE152 | |
A | HIS136-PHE152 |
site_id | SWS_FT_FI6 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | PHE163-LEU188 | |
A | PHE163-LEU188 |
site_id | SWS_FT_FI7 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=TM5 => ECO:0000269|PubMed:37880360, ECO:0000305|PubMed:37880361 |
Chain | Residue | Details |
B | PHE195-LEU220 | |
A | PHE195-LEU220 |
site_id | SWS_FT_FI8 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=TM6 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | LYS224-MET249 | |
A | LYS224-MET249 |
site_id | SWS_FT_FI9 |
Number of Residues | 62 |
Details | TRANSMEM: Helical; Name=TM7, linker => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | VAL261-HIS292 | |
A | VAL261-HIS292 |
site_id | SWS_FT_FI10 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=TM8 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | ALA297-LEU319 | |
A | ALA297-LEU319 |
site_id | SWS_FT_FI11 |
Number of Residues | 26 |
Details | TRANSMEM: Helical; Name=TM9 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | GLY323-ALA336 | |
A | GLY323-ALA336 |
site_id | SWS_FT_FI12 |
Number of Residues | 66 |
Details | TRANSMEM: Helical; Name=TM10 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | GLU344-LEU377 | |
A | GLU344-LEU377 |
site_id | SWS_FT_FI13 |
Number of Residues | 58 |
Details | TRANSMEM: Helical; Name=TM11 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | MET383-ARG412 | |
A | MET383-ARG412 |
site_id | SWS_FT_FI14 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=TM12 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | TRP419-ALA446 | |
A | TRP419-ALA446 |
site_id | SWS_FT_FI15 |
Number of Residues | 60 |
Details | TRANSMEM: Helical; Name=TM13 => ECO:0000269|PubMed:37880360, ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | ILE451-LEU481 | |
A | ILE451-LEU481 |
site_id | SWS_FT_FI16 |
Number of Residues | 60 |
Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | MET678-VAL708 | |
A | MET678-VAL708 |
site_id | SWS_FT_FI17 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | LEU725-LEU752 | |
A | LEU725-LEU752 |
site_id | SWS_FT_FI18 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | SER761-LEU784 | |
A | SER761-LEU784 |
site_id | SWS_FT_FI19 |
Number of Residues | 52 |
Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:37880361 |
Chain | Residue | Details |
B | ILE796-ILE822 | |
A | ILE796-ILE822 |
site_id | SWS_FT_FI20 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37880360 |
Chain | Residue | Details |
B | HIS73 | |
A | HIS73 |
site_id | SWS_FT_FI21 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PDV |
Chain | Residue | Details |
B | GLY1043 | |
B | GLU1044 | |
A | GLY1043 | |
A | GLU1044 |
site_id | SWS_FT_FI22 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PDU |
Chain | Residue | Details |
B | MET1045 | |
A | MET1045 |
site_id | SWS_FT_FI23 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PD9 |
Chain | Residue | Details |
B | GLY1046 | |
A | GLY1046 |
site_id | SWS_FT_FI24 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37880361, ECO:0007744|PDB:8PDU, ECO:0007744|PDB:8PDV |
Chain | Residue | Details |
B | ARG1053 | |
B | ASN1054 | |
A | ARG1053 | |
A | ASN1054 |
site_id | SWS_FT_FI25 |
Number of Residues | 2 |
Details | SITE: Contributes one equivalent gating charge => ECO:0000269|PubMed:30022052 |
Chain | Residue | Details |
B | ARG803 | |
A | ARG803 |