8OST

Structure of human terminal uridylyltransferase 4 (TUT4, ZCCHC11) in complex with pre-let7g miRNA and Lin28A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001556	biological_process	oocyte maturation
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0010586	biological_process	miRNA metabolic process
A	0010587	biological_process	miRNA catabolic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019827	biological_process	stem cell population maintenance
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0031054	biological_process	pre-miRNA processing
A	0031123	biological_process	RNA 3'-end processing
A	0035198	molecular_function	miRNA binding
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0046872	molecular_function	metal ion binding
A	0050265	molecular_function	RNA uridylyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	0071044	biological_process	histone mRNA catabolic process
A	0141008	biological_process	transposable element silencing by mRNA destabilization
A	1990074	biological_process	polyuridylation-dependent mRNA catabolic process
B	0000932	cellular_component	P-body
B	0002151	molecular_function	G-quadruplex RNA binding
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0010494	cellular_component	cytoplasmic stress granule
B	0010587	biological_process	miRNA catabolic process
B	0010608	biological_process	post-transcriptional regulation of gene expression
B	0017148	biological_process	negative regulation of translation
B	0019827	biological_process	stem cell population maintenance
B	0031047	biological_process	regulatory ncRNA-mediated gene silencing
B	0031054	biological_process	pre-miRNA processing
B	0031123	biological_process	RNA 3'-end processing
B	0031369	molecular_function	translation initiation factor binding
B	0032008	biological_process	positive regulation of TOR signaling
B	0035198	molecular_function	miRNA binding
B	0046872	molecular_function	metal ion binding
B	0048863	biological_process	stem cell differentiation
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0070883	molecular_function	pre-miRNA binding
B	0071333	biological_process	cellular response to glucose stimulus
B	0140517	molecular_function	protein-RNA adaptor activity
B	1901724	biological_process	positive regulation of cell proliferation involved in kidney development
B	1990825	molecular_function	sequence-specific mRNA binding
B	2000632	biological_process	negative regulation of pre-miRNA processing
B	2000767	biological_process	positive regulation of cytoplasmic translation

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Ckl..ClihIeniqgahkHikekrH

Chain	Residue	Details
A	CYS306-HIS328

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"PAP-associated 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31036859","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Zinc finger: {"description":"CCHC-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00047","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	17
Details	Zinc finger: {"description":"CCHC-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00047","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---