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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8OR3

CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006511biological_processubiquitin-dependent protein catabolic process
A0006879biological_processintracellular iron ion homeostasis
A0007346biological_processregulation of mitotic cell cycle
A0010564biological_processregulation of cell cycle process
A0010824biological_processregulation of centrosome duplication
A0014033biological_processneural crest cell differentiation
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030510biological_processregulation of BMP signaling pathway
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0032006biological_processregulation of TOR signaling
A0034599biological_processcellular response to oxidative stress
A0042752biological_processregulation of circadian rhythm
A0042981biological_processregulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0050727biological_processregulation of inflammatory response
A0051298biological_processcentrosome duplication
A0051726biological_processregulation of cell cycle
A0060173biological_processlimb development
A0060271biological_processcilium assembly
A0070936biological_processprotein K48-linked ubiquitination
A0097193biological_processintrinsic apoptotic signaling pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1901524biological_processregulation of mitophagy
A1904415biological_processregulation of xenophagy
A1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
A2000001biological_processregulation of DNA damage checkpoint
B0000082biological_processG1/S transition of mitotic cell cycle
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000165biological_processMAPK cascade
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006355biological_processregulation of DNA-templated transcription
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0006879biological_processintracellular iron ion homeostasis
B0006974biological_processDNA damage response
B0007283biological_processspermatogenesis
B0007346biological_processregulation of mitotic cell cycle
B0008270molecular_functionzinc ion binding
B0008283biological_processcell population proliferation
B0010506biological_processregulation of autophagy
B0010564biological_processregulation of cell cycle process
B0010824biological_processregulation of centrosome duplication
B0014033biological_processneural crest cell differentiation
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019005cellular_componentSCF ubiquitin ligase complex
B0019788molecular_functionNEDD8 transferase activity
B0030174biological_processregulation of DNA-templated DNA replication initiation
B0030510biological_processregulation of BMP signaling pathway
B0030891cellular_componentVCB complex
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031297biological_processreplication fork processing
B0031461cellular_componentcullin-RING ubiquitin ligase complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031463cellular_componentCul3-RING ubiquitin ligase complex
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0031466cellular_componentCul5-RING ubiquitin ligase complex
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0032006biological_processregulation of TOR signaling
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032480biological_processnegative regulation of type I interferon production
B0032814biological_processregulation of natural killer cell activation
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0034599biological_processcellular response to oxidative stress
B0034644biological_processcellular response to UV
B0040029biological_processepigenetic regulation of gene expression
B0042110biological_processT cell activation
B0042127biological_processregulation of cell population proliferation
B0042752biological_processregulation of circadian rhythm
B0042770biological_processsignal transduction in response to DNA damage
B0042981biological_processregulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043687biological_processpost-translational protein modification
B0044314biological_processprotein K27-linked ubiquitination
B0044877molecular_functionprotein-containing complex binding
B0045116biological_processprotein neddylation
B0045732biological_processpositive regulation of protein catabolic process
B0045995biological_processregulation of embryonic development
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046872molecular_functionmetal ion binding
B0050727biological_processregulation of inflammatory response
B0051298biological_processcentrosome duplication
B0051726biological_processregulation of cell cycle
B0060090molecular_functionmolecular adaptor activity
B0060173biological_processlimb development
B0060271biological_processcilium assembly
B0060964biological_processregulation of miRNA-mediated gene silencing
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061630molecular_functionubiquitin protein ligase activity
B0061663molecular_functionNEDD8 ligase activity
B0062197biological_processcellular response to chemical stress
B0070936biological_processprotein K48-linked ubiquitination
B0071230biological_processcellular response to amino acid stimulus
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
B0080135biological_processregulation of cellular response to stress
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090734cellular_componentsite of DNA damage
B0097602molecular_functioncullin family protein binding
B0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B0160240biological_processRNA polymerase II transcription initiation surveillance
B0160276biological_processnegative regulation of beige fat cell differentiation
B1900076biological_processregulation of cellular response to insulin stimulus
B1901524biological_processregulation of mitophagy
B1901525biological_processnegative regulation of mitophagy
B1901987biological_processregulation of cell cycle phase transition
B1902412biological_processregulation of mitotic cytokinesis
B1902499biological_processpositive regulation of protein autoubiquitination
B1902883biological_processnegative regulation of response to oxidative stress
B1904178biological_processnegative regulation of adipose tissue development
B1904263biological_processpositive regulation of TORC1 signaling
B1904415biological_processregulation of xenophagy
B1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
B2000001biological_processregulation of DNA damage checkpoint
B2000036biological_processregulation of stem cell population maintenance
B2000104biological_processnegative regulation of DNA-templated DNA replication
C0000151cellular_componentubiquitin ligase complex
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0010265biological_processSCF complex assembly
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0017025molecular_functionTBP-class protein binding
C0030154biological_processcell differentiation
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0034774cellular_componentsecretory granule lumen
C0043086biological_processnegative regulation of catalytic activity
C0045893biological_processpositive regulation of DNA-templated transcription
C0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
C0070062cellular_componentextracellular exosome
C1904813cellular_componentficolin-1-rich granule lumen
D0000082biological_processG1/S transition of mitotic cell cycle
D0000209biological_processprotein polyubiquitination
D0000785cellular_componentchromatin
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0006511biological_processubiquitin-dependent protein catabolic process
D0006879biological_processintracellular iron ion homeostasis
D0007346biological_processregulation of mitotic cell cycle
D0008013molecular_functionbeta-catenin binding
D0010564biological_processregulation of cell cycle process
D0010824biological_processregulation of centrosome duplication
D0014033biological_processneural crest cell differentiation
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019904molecular_functionprotein domain specific binding
D0030510biological_processregulation of BMP signaling pathway
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031507biological_processheterochromatin formation
D0031519cellular_componentPcG protein complex
D0032006biological_processregulation of TOR signaling
D0042752biological_processregulation of circadian rhythm
D0042981biological_processregulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045892biological_processnegative regulation of DNA-templated transcription
D0050727biological_processregulation of inflammatory response
D0051124biological_processsynaptic assembly at neuromuscular junction
D0051298biological_processcentrosome duplication
D0051457biological_processmaintenance of protein location in nucleus
D0051726biological_processregulation of cell cycle
D0060173biological_processlimb development
D0060271biological_processcilium assembly
D0070936biological_processprotein K48-linked ubiquitination
D0097602molecular_functioncullin family protein binding
D0140677molecular_functionmolecular function activator activity
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1901524biological_processregulation of mitophagy
D1904415biological_processregulation of xenophagy
D1990444molecular_functionF-box domain binding
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
D1990757molecular_functionubiquitin ligase activator activity
D2000001biological_processregulation of DNA damage checkpoint
E0000082biological_processG1/S transition of mitotic cell cycle
E0002376biological_processimmune system process
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006511biological_processubiquitin-dependent protein catabolic process
E0016567biological_processprotein ubiquitination
E0019005cellular_componentSCF ubiquitin ligase complex
E0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E0042802molecular_functionidentical protein binding
E0042981biological_processregulation of apoptotic process
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0045087biological_processinnate immune response
E0051607biological_processdefense response to virus
E0070534biological_processprotein K63-linked ubiquitination
E0070936biological_processprotein K48-linked ubiquitination
E1905168biological_processpositive regulation of double-strand break repair via homologous recombination
E1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F0000151cellular_componentubiquitin ligase complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0031396biological_processregulation of protein ubiquitination
F0031624molecular_functionubiquitin conjugating enzyme binding
F0032182molecular_functionubiquitin-like protein binding
F0045116biological_processprotein neddylation
F0097602molecular_functioncullin family protein binding
F2000434biological_processregulation of protein neddylation
F2000436biological_processpositive regulation of protein neddylation
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA
ChainResidueDetails
AILE749-ALA776
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsDomain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"10597293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18805092","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues45
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues37
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues34
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues34
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues37
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues43
DetailsRepeat: {"description":"HEAT 10"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues39
DetailsRepeat: {"description":"HEAT 11"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues37
DetailsRepeat: {"description":"HEAT 12"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues39
DetailsRepeat: {"description":"HEAT 13"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues37
DetailsRepeat: {"description":"HEAT 14"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues37
DetailsRepeat: {"description":"HEAT 15"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues37
DetailsRepeat: {"description":"HEAT 16"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues39
DetailsRepeat: {"description":"HEAT 17"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues36
DetailsRepeat: {"description":"HEAT 19"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues37
DetailsRepeat: {"description":"HEAT 20"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues37
DetailsRepeat: {"description":"HEAT 21"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues32
DetailsRepeat: {"description":"HEAT 22"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues37
DetailsRepeat: {"description":"HEAT 23"}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues37
DetailsRepeat: {"description":"HEAT 24"}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues54
DetailsRepeat: {"description":"HEAT 25"}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues34
DetailsRepeat: {"description":"HEAT 26"}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues49
DetailsRepeat: {"description":"HEAT 27"}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues1
DetailsSite: {"description":"Essential for interaction with UBE2M","evidences":[{"source":"PubMed","id":"28581483","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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