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8OR3

CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006511biological_processubiquitin-dependent protein catabolic process
A0006513biological_processprotein monoubiquitination
A0006915biological_processapoptotic process
A0008283biological_processcell population proliferation
A0009887biological_processanimal organ morphogenesis
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0070936biological_processprotein K48-linked ubiquitination
A0097193biological_processintrinsic apoptotic signaling pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
B0000165biological_processMAPK cascade
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0006974biological_processDNA damage response
B0007283biological_processspermatogenesis
B0008270molecular_functionzinc ion binding
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019005cellular_componentSCF ubiquitin ligase complex
B0019788molecular_functionNEDD8 transferase activity
B0030163biological_processprotein catabolic process
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031461cellular_componentcullin-RING ubiquitin ligase complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031463cellular_componentCul3-RING ubiquitin ligase complex
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0031466cellular_componentCul5-RING ubiquitin ligase complex
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032480biological_processnegative regulation of type I interferon production
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0034644biological_processcellular response to UV
B0042110biological_processT cell activation
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043687biological_processpost-translational protein modification
B0045116biological_processprotein neddylation
B0045732biological_processpositive regulation of protein catabolic process
B0046872molecular_functionmetal ion binding
B0060090molecular_functionmolecular adaptor activity
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061630molecular_functionubiquitin protein ligase activity
B0061663molecular_functionNEDD8 ligase activity
B0062197biological_processcellular response to chemical stress
B0070936biological_processprotein K48-linked ubiquitination
B0071230biological_processcellular response to amino acid stimulus
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0097602molecular_functioncullin family protein binding
B0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B1900076biological_processregulation of cellular response to insulin stimulus
B1902499biological_processpositive regulation of protein autoubiquitination
B1902883biological_processnegative regulation of response to oxidative stress
B1904263biological_processpositive regulation of TORC1 signaling
C0000151cellular_componentubiquitin ligase complex
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0010265biological_processSCF complex assembly
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0017025molecular_functionTBP-class protein binding
C0030154biological_processcell differentiation
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0034774cellular_componentsecretory granule lumen
C0043086biological_processnegative regulation of catalytic activity
C0045893biological_processpositive regulation of DNA-templated transcription
C0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
C0070062cellular_componentextracellular exosome
C1904813cellular_componentficolin-1-rich granule lumen
D0000209biological_processprotein polyubiquitination
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0008013molecular_functionbeta-catenin binding
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019904molecular_functionprotein domain specific binding
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031519cellular_componentPcG protein complex
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051457biological_processmaintenance of protein location in nucleus
D0070936biological_processprotein K48-linked ubiquitination
D0097602molecular_functioncullin family protein binding
D0140677molecular_functionmolecular function activator activity
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1904668biological_processpositive regulation of ubiquitin protein ligase activity
D1990444molecular_functionF-box domain binding
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
E0000082biological_processG1/S transition of mitotic cell cycle
E0000086biological_processG2/M transition of mitotic cell cycle
E0000209biological_processprotein polyubiquitination
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006511biological_processubiquitin-dependent protein catabolic process
E0016567biological_processprotein ubiquitination
E0019005cellular_componentSCF ubiquitin ligase complex
E0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E0033148biological_processpositive regulation of intracellular estrogen receptor signaling pathway
E0042802molecular_functionidentical protein binding
E0042981biological_processregulation of apoptotic process
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0045087biological_processinnate immune response
E0051607biological_processdefense response to virus
E0051726biological_processregulation of cell cycle
E0070534biological_processprotein K63-linked ubiquitination
E0070936biological_processprotein K48-linked ubiquitination
E1902916biological_processpositive regulation of protein polyubiquitination
E1905168biological_processpositive regulation of double-strand break repair via homologous recombination
E1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F0000151cellular_componentubiquitin ligase complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0031396biological_processregulation of protein ubiquitination
F0031624molecular_functionubiquitin conjugating enzyme binding
F0032182molecular_functionubiquitin-like protein binding
F0045116biological_processprotein neddylation
F0097602molecular_functioncullin family protein binding
F2000434biological_processregulation of protein neddylation
F2000436biological_processpositive regulation of protein neddylation
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA
ChainResidueDetails
AILE749-ALA776

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Essential for interaction with UBE2M => ECO:0000269|PubMed:28581483
ChainResidueDetails
FCYS115

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
FMET1
BCYS94
BASP97
ELYS71
BCYS53
BCYS56
BCYS68
BCYS75
BHIS77
BHIS80
BHIS82

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER72
ESER75

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER179

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
BALA2

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR9

225399

PDB entries from 2024-09-25

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