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8OQQ

Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-79

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
A0004300molecular_functionenoyl-CoA hydratase activity
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006631biological_processfatty acid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0009274cellular_componentpeptidoglycan-based cell wall
A0016042biological_processlipid catabolic process
A0016491molecular_functionoxidoreductase activity
A0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0016829molecular_functionlyase activity
A0070403molecular_functionNAD+ binding
B0000166molecular_functionnucleotide binding
B0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
B0004300molecular_functionenoyl-CoA hydratase activity
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0009274cellular_componentpeptidoglycan-based cell wall
B0016042biological_processlipid catabolic process
B0016491molecular_functionoxidoreductase activity
B0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0016829molecular_functionlyase activity
B0070403molecular_functionNAD+ binding
C0003985molecular_functionacetyl-CoA C-acetyltransferase activity
C0005886cellular_componentplasma membrane
C0009274cellular_componentpeptidoglycan-based cell wall
C0016746molecular_functionacyltransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
D0003985molecular_functionacetyl-CoA C-acetyltransferase activity
D0005886cellular_componentplasma membrane
D0009274cellular_componentpeptidoglycan-based cell wall
D0016746molecular_functionacyltransferase activity
D0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
Functional Information from PROSITE/UniProt
site_idPS00098
Number of Residues19
DetailsTHIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNRfCASGLeAVntaaqkV
ChainResidueDetails
CLEU88-VAL106

site_idPS00099
Number of Residues14
DetailsTHIOLASE_3 Thiolases active site. ALITLCIGgGmGvA
ChainResidueDetails
CALA384-ALA397

site_idPS00737
Number of Residues17
DetailsTHIOLASE_2 Thiolases signature 2. NvnGGaIAmGHPlGaTG
ChainResidueDetails
CASN349-GLY365

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Acyl-thioester intermediate => ECO:0000250
ChainResidueDetails
CCYS92
DCYS92

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020
ChainResidueDetails
CHIS359
CCYS389
DHIS359
DCYS389

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036
ChainResidueDetails
CLYS189
DLYS189

227344

PDB entries from 2024-11-13

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