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8OQ3

Structure of methylamine treated human complement C3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001798biological_processpositive regulation of type IIa hypersensitivity
A0001934biological_processpositive regulation of protein phosphorylation
A0001970biological_processpositive regulation of activation of membrane attack complex
A0002430biological_processcomplement receptor mediated signaling pathway
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0006631biological_processfatty acid metabolic process
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0009617biological_processresponse to bacterium
A0009986cellular_componentcell surface
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010828biological_processpositive regulation of glucose transmembrane transport
A0010866biological_processregulation of triglyceride biosynthetic process
A0010884biological_processpositive regulation of lipid storage
A0016322biological_processneuron remodeling
A0031715molecular_functionC5L2 anaphylatoxin chemotactic receptor binding
A0032991cellular_componentprotein-containing complex
A0034774cellular_componentsecretory granule lumen
A0035578cellular_componentazurophil granule lumen
A0035846biological_processoviduct epithelium development
A0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
A0045766biological_processpositive regulation of angiogenesis
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050766biological_processpositive regulation of phagocytosis
A0060100biological_processpositive regulation of phagocytosis, engulfment
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0097242biological_processamyloid-beta clearance
A0097278biological_processcomplement-dependent cytotoxicity
A0150062biological_processcomplement-mediated synapse pruning
A0150064biological_processvertebrate eye-specific patterning
A2000427biological_processpositive regulation of apoptotic cell clearance
D0001798biological_processpositive regulation of type IIa hypersensitivity
D0001934biological_processpositive regulation of protein phosphorylation
D0001970biological_processpositive regulation of activation of membrane attack complex
D0002430biological_processcomplement receptor mediated signaling pathway
D0005102molecular_functionsignaling receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005788cellular_componentendoplasmic reticulum lumen
D0005886cellular_componentplasma membrane
D0006631biological_processfatty acid metabolic process
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0006958biological_processcomplement activation, classical pathway
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0009617biological_processresponse to bacterium
D0009986cellular_componentcell surface
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010828biological_processpositive regulation of glucose transmembrane transport
D0010866biological_processregulation of triglyceride biosynthetic process
D0010884biological_processpositive regulation of lipid storage
D0016322biological_processneuron remodeling
D0031715molecular_functionC5L2 anaphylatoxin chemotactic receptor binding
D0032991cellular_componentprotein-containing complex
D0034774cellular_componentsecretory granule lumen
D0035578cellular_componentazurophil granule lumen
D0035846biological_processoviduct epithelium development
D0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
D0045766biological_processpositive regulation of angiogenesis
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0050766biological_processpositive regulation of phagocytosis
D0060100biological_processpositive regulation of phagocytosis, engulfment
D0070062cellular_componentextracellular exosome
D0072562cellular_componentblood microparticle
D0097242biological_processamyloid-beta clearance
D0097278biological_processcomplement-dependent cytotoxicity
D0150062biological_processcomplement-mediated synapse pruning
D0150064biological_processvertebrate eye-specific patterning
D2000427biological_processpositive regulation of apoptotic cell clearance
Functional Information from PROSITE/UniProt
site_idPS00477
Number of Residues9
DetailsALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM
ChainResidueDetails
APRO1007-MET1015

site_idPS01177
Number of Residues36
DetailsANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCedGmrenpmrfSCQrrtrfisl.GeaCkkvfld.CC
ChainResidueDetails
ACYS693-CYS728

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by S.pyogenes SpeB => ECO:0000269|PubMed:18160402
ChainResidueDetails
ASER541
DSER541

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by carboxypeptidases
ChainResidueDetails
AALA747
DALA747

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by C3 convertase
ChainResidueDetails
AARG748
DARG748

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Cleavage; by factor I => ECO:0000255
ChainResidueDetails
AARG954
DARG954

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Cleavage; by factor I
ChainResidueDetails
AARG1303
AARG1320
DARG1303
DARG1320

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604
ChainResidueDetails
AASN1663
DASN1663

site_idSWS_FT_FI7
Number of Residues16
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER38
ASER70
ASER297
ASER303
ASER672
ASER968
ASER1321
ASER1573
DSER38
DSER70
DSER297
DSER303
DSER672
DSER968
DSER1321
DSER1573

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150, ECO:0000269|PubMed:17684013, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2579379
ChainResidueDetails
AASN85
DASN85

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150
ChainResidueDetails
AASN939
DASN939

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN1617
DASN1617

site_idSWS_FT_FI11
Number of Residues4
DetailsCROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)
ChainResidueDetails
ACYS1010
AGLN1013
DCYS1010
DGLN1013

221051

PDB entries from 2024-06-12

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