Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8OQ3

Structure of methylamine treated human complement C3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001798biological_processpositive regulation of type IIa hypersensitivity
A0001934biological_processpositive regulation of protein phosphorylation
A0001970biological_processpositive regulation of activation of membrane attack complex
A0002376biological_processimmune system process
A0002430biological_processcomplement receptor mediated signaling pathway
A0004866molecular_functionendopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0009617biological_processresponse to bacterium
A0009986cellular_componentcell surface
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010828biological_processpositive regulation of D-glucose transmembrane transport
A0010866biological_processregulation of triglyceride biosynthetic process
A0010884biological_processpositive regulation of lipid storage
A0016322biological_processneuron remodeling
A0031715molecular_functionC5L2 anaphylatoxin chemotactic receptor binding
A0032991cellular_componentprotein-containing complex
A0034774cellular_componentsecretory granule lumen
A0035578cellular_componentazurophil granule lumen
A0035846biological_processoviduct epithelium development
A0042113biological_processB cell activation
A0045087biological_processinnate immune response
A0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
A0045766biological_processpositive regulation of angiogenesis
A0048018molecular_functionreceptor ligand activity
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050766biological_processpositive regulation of phagocytosis
A0060100biological_processpositive regulation of phagocytosis, engulfment
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0097242biological_processamyloid-beta clearance
A0097278biological_processcomplement-dependent cytotoxicity
A0150062biological_processcomplement-mediated synapse pruning
A0150064biological_processvertebrate eye-specific patterning
A0160257biological_processcomplement activation, GZMK pathway
A2000427biological_processpositive regulation of apoptotic cell clearance
D0001798biological_processpositive regulation of type IIa hypersensitivity
D0001934biological_processpositive regulation of protein phosphorylation
D0001970biological_processpositive regulation of activation of membrane attack complex
D0002376biological_processimmune system process
D0002430biological_processcomplement receptor mediated signaling pathway
D0004866molecular_functionendopeptidase inhibitor activity
D0005102molecular_functionsignaling receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005788cellular_componentendoplasmic reticulum lumen
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0006958biological_processcomplement activation, classical pathway
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0009617biological_processresponse to bacterium
D0009986cellular_componentcell surface
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010828biological_processpositive regulation of D-glucose transmembrane transport
D0010866biological_processregulation of triglyceride biosynthetic process
D0010884biological_processpositive regulation of lipid storage
D0016322biological_processneuron remodeling
D0031715molecular_functionC5L2 anaphylatoxin chemotactic receptor binding
D0032991cellular_componentprotein-containing complex
D0034774cellular_componentsecretory granule lumen
D0035578cellular_componentazurophil granule lumen
D0035846biological_processoviduct epithelium development
D0042113biological_processB cell activation
D0045087biological_processinnate immune response
D0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
D0045766biological_processpositive regulation of angiogenesis
D0048018molecular_functionreceptor ligand activity
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0050766biological_processpositive regulation of phagocytosis
D0060100biological_processpositive regulation of phagocytosis, engulfment
D0070062cellular_componentextracellular exosome
D0072562cellular_componentblood microparticle
D0097242biological_processamyloid-beta clearance
D0097278biological_processcomplement-dependent cytotoxicity
D0150062biological_processcomplement-mediated synapse pruning
D0150064biological_processvertebrate eye-specific patterning
D0160257biological_processcomplement activation, GZMK pathway
D2000427biological_processpositive regulation of apoptotic cell clearance
Functional Information from PROSITE/UniProt
site_idPS00477
Number of Residues9
DetailsALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM
ChainResidueDetails
APRO1007-MET1015
site_idPS01177
Number of Residues36
DetailsANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCedGmrenpmrfSCQrrtrfisl.GeaCkkvfld.CC
ChainResidueDetails
ACYS693-CYS728
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsPeptide: {"description":"Complement C3f fragment","featureId":"PRO_0000005916","evidences":[{"source":"PubMed","id":"8376604","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues286
DetailsDomain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues38
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues50
DetailsRegion: {"description":"Interaction with CFP/properdin","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Cleavage; by S.pyogenes SpeB","evidences":[{"source":"PubMed","id":"18160402","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsSite: {"description":"Cleavage; by factor I","evidences":[{"source":"PubMed","id":"28671664","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"Coordinates Mg(2+) for interaction with Complement factor B Bb fragment (CFB)","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues14
DetailsModified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17051150","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17684013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2579379","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17051150","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsCross-link: {"description":"Isoglutamyl cysteine thioester (Cys-Gln)","evidences":[{"source":"PubMed","id":"1577777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6175959","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

PDB statisticsPDBj update infoContact PDBjnumon