8OP9
CryoEM structure of human rho1 GABAA receptor in complex with GABA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0004890 | molecular_function | GABA-A receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0004890 | molecular_function | GABA-A receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0004890 | molecular_function | GABA-A receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0004890 | molecular_function | GABA-A receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0004890 | molecular_function | GABA-A receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CnMdFsrFPlDtqtC |
| Chain | Residue | Details |
| A | CYS198-CYS212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1345 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | THR22-HIS280 | |
| D | THR22-HIS280 | |
| D | MET335-ASP345 | |
| D | SER479 | |
| E | THR22-HIS280 | |
| E | MET335-ASP345 | |
| E | SER479 | |
| A | MET335-ASP345 | |
| A | SER479 | |
| B | THR22-HIS280 | |
| B | MET335-ASP345 | |
| B | SER479 | |
| C | THR22-HIS280 | |
| C | MET335-ASP345 | |
| C | SER479 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 400 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE281-VAL301 | |
| C | VAL314-SER334 | |
| C | ILE346-ASN366 | |
| C | TYR458-PHE478 | |
| D | ILE281-VAL301 | |
| D | VAL314-SER334 | |
| D | ILE346-ASN366 | |
| D | TYR458-PHE478 | |
| E | ILE281-VAL301 | |
| E | VAL314-SER334 | |
| E | ILE346-ASN366 | |
| A | VAL314-SER334 | |
| E | TYR458-PHE478 | |
| A | ILE346-ASN366 | |
| A | TYR458-PHE478 | |
| B | ILE281-VAL301 | |
| B | VAL314-SER334 | |
| B | ILE346-ASN366 | |
| B | TYR458-PHE478 | |
| C | ILE281-VAL301 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 505 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | SER302-ARG313 | |
| E | TYR367-LYS457 | |
| A | TYR367-LYS457 | |
| B | SER302-ARG313 | |
| B | TYR367-LYS457 | |
| C | SER302-ARG313 | |
| C | TYR367-LYS457 | |
| D | SER302-ARG313 | |
| D | TYR367-LYS457 | |
| E | SER302-ARG313 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:37659407, ECO:0007744|PDB:8OP9 |
| Chain | Residue | Details |
| A | ARG125 | |
| E | SER189 | |
| A | SER189 | |
| B | ARG125 | |
| B | SER189 | |
| C | ARG125 | |
| C | SER189 | |
| D | ARG125 | |
| D | SER189 | |
| E | ARG125 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:37659407, ECO:0007744|PDB:8OP9 |
| Chain | Residue | Details |
| A | GLU217 | |
| B | GLU217 | |
| C | GLU217 | |
| D | GLU217 | |
| E | GLU217 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:37659407, ECO:0007744|PDB:8OP9 |
| Chain | Residue | Details |
| A | ASN140 | |
| E | ASN234 | |
| A | ASN234 | |
| B | ASN140 | |
| B | ASN234 | |
| C | ASN140 | |
| C | ASN234 | |
| D | ASN140 | |
| D | ASN234 | |
| E | ASN140 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN274 | |
| B | ASN274 | |
| C | ASN274 | |
| D | ASN274 | |
| E | ASN274 |
