8OOS
CryoEM Structure INO80core Hexasome complex ATPase-hexasome refinement state 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| G | 0003677 | molecular_function | DNA binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0006281 | biological_process | DNA repair |
| G | 0006338 | biological_process | chromatin remodeling |
| G | 0006351 | biological_process | DNA-templated transcription |
| G | 0031011 | cellular_component | Ino80 complex |
| G | 0140658 | molecular_function | ATP-dependent chromatin remodeler activity |
| M | 0000786 | cellular_component | nucleosome |
| M | 0003677 | molecular_function | DNA binding |
| M | 0005515 | molecular_function | protein binding |
| M | 0005576 | cellular_component | extracellular region |
| M | 0005634 | cellular_component | nucleus |
| M | 0005654 | cellular_component | nucleoplasm |
| M | 0005694 | cellular_component | chromosome |
| M | 0006325 | biological_process | chromatin organization |
| M | 0006334 | biological_process | nucleosome assembly |
| M | 0010467 | biological_process | gene expression |
| M | 0016020 | cellular_component | membrane |
| M | 0030527 | molecular_function | structural constituent of chromatin |
| M | 0032200 | biological_process | telomere organization |
| M | 0032991 | cellular_component | protein-containing complex |
| M | 0040029 | biological_process | epigenetic regulation of gene expression |
| M | 0045296 | molecular_function | cadherin binding |
| M | 0046982 | molecular_function | protein heterodimerization activity |
| M | 0070062 | cellular_component | extracellular exosome |
| N | 0000781 | cellular_component | chromosome, telomeric region |
| N | 0000786 | cellular_component | nucleosome |
| N | 0003677 | molecular_function | DNA binding |
| N | 0003723 | molecular_function | RNA binding |
| N | 0005515 | molecular_function | protein binding |
| N | 0005576 | cellular_component | extracellular region |
| N | 0005634 | cellular_component | nucleus |
| N | 0005654 | cellular_component | nucleoplasm |
| N | 0005694 | cellular_component | chromosome |
| N | 0006325 | biological_process | chromatin organization |
| N | 0006334 | biological_process | nucleosome assembly |
| N | 0016020 | cellular_component | membrane |
| N | 0030527 | molecular_function | structural constituent of chromatin |
| N | 0032200 | biological_process | telomere organization |
| N | 0032991 | cellular_component | protein-containing complex |
| N | 0043505 | cellular_component | CENP-A containing nucleosome |
| N | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| N | 0046982 | molecular_function | protein heterodimerization activity |
| N | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| N | 0070062 | cellular_component | extracellular exosome |
| O | 0000786 | cellular_component | nucleosome |
| O | 0003677 | molecular_function | DNA binding |
| O | 0005515 | molecular_function | protein binding |
| O | 0005634 | cellular_component | nucleus |
| O | 0005654 | cellular_component | nucleoplasm |
| O | 0005694 | cellular_component | chromosome |
| O | 0008285 | biological_process | negative regulation of cell population proliferation |
| O | 0030527 | molecular_function | structural constituent of chromatin |
| O | 0031507 | biological_process | heterochromatin formation |
| O | 0046982 | molecular_function | protein heterodimerization activity |
| O | 0070062 | cellular_component | extracellular exosome |
| P | 0000786 | cellular_component | nucleosome |
| P | 0002227 | biological_process | innate immune response in mucosa |
| P | 0003677 | molecular_function | DNA binding |
| P | 0005515 | molecular_function | protein binding |
| P | 0005615 | cellular_component | extracellular space |
| P | 0005634 | cellular_component | nucleus |
| P | 0005654 | cellular_component | nucleoplasm |
| P | 0005694 | cellular_component | chromosome |
| P | 0005829 | cellular_component | cytosol |
| P | 0006334 | biological_process | nucleosome assembly |
| P | 0019731 | biological_process | antibacterial humoral response |
| P | 0030527 | molecular_function | structural constituent of chromatin |
| P | 0042742 | biological_process | defense response to bacterium |
| P | 0042802 | molecular_function | identical protein binding |
| P | 0046982 | molecular_function | protein heterodimerization activity |
| P | 0050830 | biological_process | defense response to Gram-positive bacterium |
| P | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| P | 0070062 | cellular_component | extracellular exosome |
| Q | 0000786 | cellular_component | nucleosome |
| Q | 0003677 | molecular_function | DNA binding |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005576 | cellular_component | extracellular region |
| Q | 0005634 | cellular_component | nucleus |
| Q | 0005654 | cellular_component | nucleoplasm |
| Q | 0005694 | cellular_component | chromosome |
| Q | 0006325 | biological_process | chromatin organization |
| Q | 0006334 | biological_process | nucleosome assembly |
| Q | 0010467 | biological_process | gene expression |
| Q | 0016020 | cellular_component | membrane |
| Q | 0030527 | molecular_function | structural constituent of chromatin |
| Q | 0032200 | biological_process | telomere organization |
| Q | 0032991 | cellular_component | protein-containing complex |
| Q | 0040029 | biological_process | epigenetic regulation of gene expression |
| Q | 0045296 | molecular_function | cadherin binding |
| Q | 0046982 | molecular_function | protein heterodimerization activity |
| Q | 0070062 | cellular_component | extracellular exosome |
| R | 0000781 | cellular_component | chromosome, telomeric region |
| R | 0000786 | cellular_component | nucleosome |
| R | 0003677 | molecular_function | DNA binding |
| R | 0003723 | molecular_function | RNA binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005576 | cellular_component | extracellular region |
| R | 0005634 | cellular_component | nucleus |
| R | 0005654 | cellular_component | nucleoplasm |
| R | 0005694 | cellular_component | chromosome |
| R | 0006325 | biological_process | chromatin organization |
| R | 0006334 | biological_process | nucleosome assembly |
| R | 0016020 | cellular_component | membrane |
| R | 0030527 | molecular_function | structural constituent of chromatin |
| R | 0032200 | biological_process | telomere organization |
| R | 0032991 | cellular_component | protein-containing complex |
| R | 0043505 | cellular_component | CENP-A containing nucleosome |
| R | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| R | 0046982 | molecular_function | protein heterodimerization activity |
| R | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| R | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| O | ALA21-VAL27 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| N | GLY14-HIS18 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| M | LYS14-LEU20 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| P | ARG89-GLY111 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| M | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | DNA_BIND: |
| Chain | Residue | Details |
| N | LYS16-LYS20 | |
| R | LYS16-LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882 |
| Chain | Residue | Details |
| N | SER1 | |
| R | SER1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| N | ARG3 | |
| R | ARG3 | |
| P | LYS12 | |
| P | LYS13 | |
| P | LYS17 | |
| P | LYS20 | |
| P | LYS40 | |
| P | LYS82 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732 |
| Chain | Residue | Details |
| N | LYS5 | |
| R | LYS5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393 |
| Chain | Residue | Details |
| N | LYS8 | |
| N | LYS16 | |
| N | LYS44 | |
| R | LYS8 | |
| R | LYS16 | |
| R | LYS44 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| N | LYS12 | |
| N | LYS31 | |
| N | LYS77 | |
| N | LYS91 | |
| R | LYS12 | |
| R | LYS31 | |
| R | LYS77 | |
| R | LYS91 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793 |
| Chain | Residue | Details |
| N | LYS20 | |
| R | LYS20 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21724829, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| N | SER47 | |
| R | SER47 | |
| P | LYS117 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| N | TYR51 | |
| R | TYR51 | |
| O | LYS125 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| Chain | Residue | Details |
| N | LYS59 | |
| R | LYS59 | |
| Q | LYS14 | |
| Q | LYS56 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| N | LYS79 | |
| R | LYS79 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| N | THR80 | |
| R | THR80 | |
| Q | LYS18 | |
| Q | LYS64 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| N | TYR88 | |
| R | TYR88 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| N | LYS12 | |
| R | LYS12 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:19818714 |
| Chain | Residue | Details |
| M | LYS27 | |
| N | LYS91 | |
| R | LYS91 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| N | LYS20 | |
| N | LYS59 | |
| N | LYS79 | |
| R | LYS20 | |
| R | LYS59 | |
| R | LYS79 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146 |
| Chain | Residue | Details |
| N | LYS31 | |
| R | LYS31 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:15983376 |
| Chain | Residue | Details |
| M | LYS37 | |
| Q | LYS37 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19783980 |
| Chain | Residue | Details |
| M | TYR41 | |
| Q | TYR41 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016 |
| Chain | Residue | Details |
| M | SER57 | |
| Q | SER57 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711 |
| Chain | Residue | Details |
| M | LYS79 | |
| Q | LYS79 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016 |
| Chain | Residue | Details |
| M | THR80 | |
| Q | THR80 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| M | SER86 | |
| Q | SER86 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| M | THR107 | |
| Q | THR107 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| Chain | Residue | Details |
| M | LYS115 | |
| Q | LYS115 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229 |
| Chain | Residue | Details |
| M | LYS122 | |
| Q | LYS122 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 2 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| M | LYS18 | |
| Q | LYS18 |
