8OOS
CryoEM Structure INO80core Hexasome complex ATPase-hexasome refinement state 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| G | 0003677 | molecular_function | DNA binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0006281 | biological_process | DNA repair |
| G | 0006338 | biological_process | chromatin remodeling |
| G | 0006351 | biological_process | DNA-templated transcription |
| G | 0031011 | cellular_component | Ino80 complex |
| G | 0140658 | molecular_function | ATP-dependent chromatin remodeler activity |
| M | 0000786 | cellular_component | nucleosome |
| M | 0003677 | molecular_function | DNA binding |
| M | 0005515 | molecular_function | protein binding |
| M | 0005576 | cellular_component | extracellular region |
| M | 0005634 | cellular_component | nucleus |
| M | 0005654 | cellular_component | nucleoplasm |
| M | 0005694 | cellular_component | chromosome |
| M | 0006325 | biological_process | chromatin organization |
| M | 0006334 | biological_process | nucleosome assembly |
| M | 0016020 | cellular_component | membrane |
| M | 0030527 | molecular_function | structural constituent of chromatin |
| M | 0031492 | molecular_function | nucleosomal DNA binding |
| M | 0031507 | biological_process | heterochromatin formation |
| M | 0032200 | biological_process | telomere organization |
| M | 0032991 | cellular_component | protein-containing complex |
| M | 0040029 | biological_process | epigenetic regulation of gene expression |
| M | 0045296 | molecular_function | cadherin binding |
| M | 0046982 | molecular_function | protein heterodimerization activity |
| M | 0070062 | cellular_component | extracellular exosome |
| N | 0000781 | cellular_component | chromosome, telomeric region |
| N | 0000786 | cellular_component | nucleosome |
| N | 0003677 | molecular_function | DNA binding |
| N | 0003723 | molecular_function | RNA binding |
| N | 0005515 | molecular_function | protein binding |
| N | 0005576 | cellular_component | extracellular region |
| N | 0005634 | cellular_component | nucleus |
| N | 0005654 | cellular_component | nucleoplasm |
| N | 0005694 | cellular_component | chromosome |
| N | 0006325 | biological_process | chromatin organization |
| N | 0006334 | biological_process | nucleosome assembly |
| N | 0016020 | cellular_component | membrane |
| N | 0030527 | molecular_function | structural constituent of chromatin |
| N | 0032200 | biological_process | telomere organization |
| N | 0032991 | cellular_component | protein-containing complex |
| N | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| N | 0046982 | molecular_function | protein heterodimerization activity |
| N | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| N | 0070062 | cellular_component | extracellular exosome |
| O | 0000786 | cellular_component | nucleosome |
| O | 0003677 | molecular_function | DNA binding |
| O | 0005515 | molecular_function | protein binding |
| O | 0005634 | cellular_component | nucleus |
| O | 0005654 | cellular_component | nucleoplasm |
| O | 0005694 | cellular_component | chromosome |
| O | 0006325 | biological_process | chromatin organization |
| O | 0008285 | biological_process | negative regulation of cell population proliferation |
| O | 0030527 | molecular_function | structural constituent of chromatin |
| O | 0031507 | biological_process | heterochromatin formation |
| O | 0046982 | molecular_function | protein heterodimerization activity |
| O | 0070062 | cellular_component | extracellular exosome |
| P | 0000786 | cellular_component | nucleosome |
| P | 0002227 | biological_process | innate immune response in mucosa |
| P | 0003677 | molecular_function | DNA binding |
| P | 0005515 | molecular_function | protein binding |
| P | 0005615 | cellular_component | extracellular space |
| P | 0005634 | cellular_component | nucleus |
| P | 0005654 | cellular_component | nucleoplasm |
| P | 0005694 | cellular_component | chromosome |
| P | 0006325 | biological_process | chromatin organization |
| P | 0006334 | biological_process | nucleosome assembly |
| P | 0019731 | biological_process | antibacterial humoral response |
| P | 0030527 | molecular_function | structural constituent of chromatin |
| P | 0042742 | biological_process | defense response to bacterium |
| P | 0042802 | molecular_function | identical protein binding |
| P | 0046982 | molecular_function | protein heterodimerization activity |
| P | 0050830 | biological_process | defense response to Gram-positive bacterium |
| P | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| P | 0070062 | cellular_component | extracellular exosome |
| Q | 0000786 | cellular_component | nucleosome |
| Q | 0003677 | molecular_function | DNA binding |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005576 | cellular_component | extracellular region |
| Q | 0005634 | cellular_component | nucleus |
| Q | 0005654 | cellular_component | nucleoplasm |
| Q | 0005694 | cellular_component | chromosome |
| Q | 0006325 | biological_process | chromatin organization |
| Q | 0006334 | biological_process | nucleosome assembly |
| Q | 0016020 | cellular_component | membrane |
| Q | 0030527 | molecular_function | structural constituent of chromatin |
| Q | 0031492 | molecular_function | nucleosomal DNA binding |
| Q | 0031507 | biological_process | heterochromatin formation |
| Q | 0032200 | biological_process | telomere organization |
| Q | 0032991 | cellular_component | protein-containing complex |
| Q | 0040029 | biological_process | epigenetic regulation of gene expression |
| Q | 0045296 | molecular_function | cadherin binding |
| Q | 0046982 | molecular_function | protein heterodimerization activity |
| Q | 0070062 | cellular_component | extracellular exosome |
| R | 0000781 | cellular_component | chromosome, telomeric region |
| R | 0000786 | cellular_component | nucleosome |
| R | 0003677 | molecular_function | DNA binding |
| R | 0003723 | molecular_function | RNA binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005576 | cellular_component | extracellular region |
| R | 0005634 | cellular_component | nucleus |
| R | 0005654 | cellular_component | nucleoplasm |
| R | 0005694 | cellular_component | chromosome |
| R | 0006325 | biological_process | chromatin organization |
| R | 0006334 | biological_process | nucleosome assembly |
| R | 0016020 | cellular_component | membrane |
| R | 0030527 | molecular_function | structural constituent of chromatin |
| R | 0032200 | biological_process | telomere organization |
| R | 0032991 | cellular_component | protein-containing complex |
| R | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| R | 0046982 | molecular_function | protein heterodimerization activity |
| R | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| R | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| O | ALA21-VAL27 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| N | GLY14-HIS18 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| M | LYS14-LEU20 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| P | ARG89-GLY111 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| M | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"15983376","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 11 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-(beta-hydroxybutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"27105115","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"15386022","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16359901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16702407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25470042","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q6ZWY9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI36 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"22121020","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22121020","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
