8OOP

CryoEM Structure INO80core Hexasome complex composite model state2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000492	biological_process	box C/D snoRNP assembly
A	0000812	cellular_component	Swr1 complex
A	0003678	molecular_function	DNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031011	cellular_component	Ino80 complex
A	0032508	biological_process	DNA duplex unwinding
A	0035267	cellular_component	NuA4 histone acetyltransferase complex
A	0097255	cellular_component	R2TP complex
B	0000492	biological_process	box C/D snoRNP assembly
B	0000812	cellular_component	Swr1 complex
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0031011	cellular_component	Ino80 complex
B	0032508	biological_process	DNA duplex unwinding
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0097255	cellular_component	R2TP complex
C	0000492	biological_process	box C/D snoRNP assembly
C	0000812	cellular_component	Swr1 complex
C	0003678	molecular_function	DNA helicase activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0006281	biological_process	DNA repair
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0031011	cellular_component	Ino80 complex
C	0032508	biological_process	DNA duplex unwinding
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
C	0097255	cellular_component	R2TP complex
D	0000492	biological_process	box C/D snoRNP assembly
D	0000812	cellular_component	Swr1 complex
D	0003678	molecular_function	DNA helicase activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0006281	biological_process	DNA repair
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0031011	cellular_component	Ino80 complex
D	0032508	biological_process	DNA duplex unwinding
D	0035267	cellular_component	NuA4 histone acetyltransferase complex
D	0097255	cellular_component	R2TP complex
E	0000492	biological_process	box C/D snoRNP assembly
E	0000812	cellular_component	Swr1 complex
E	0003678	molecular_function	DNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0031011	cellular_component	Ino80 complex
E	0032508	biological_process	DNA duplex unwinding
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0097255	cellular_component	R2TP complex
F	0000492	biological_process	box C/D snoRNP assembly
F	0000812	cellular_component	Swr1 complex
F	0003678	molecular_function	DNA helicase activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0006281	biological_process	DNA repair
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0031011	cellular_component	Ino80 complex
F	0032508	biological_process	DNA duplex unwinding
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0097255	cellular_component	R2TP complex
G	0003677	molecular_function	DNA binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0006281	biological_process	DNA repair
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0031011	cellular_component	Ino80 complex
G	0140658	molecular_function	ATP-dependent chromatin remodeler activity
H	0006338	biological_process	chromatin remodeling
H	0031011	cellular_component	Ino80 complex
I	0005634	cellular_component	nucleus
I	0006338	biological_process	chromatin remodeling
I	0031011	cellular_component	Ino80 complex
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0006325	biological_process	chromatin organization
M	0006334	biological_process	nucleosome assembly
M	0010467	biological_process	gene expression
M	0016020	cellular_component	membrane
M	0030527	molecular_function	structural constituent of chromatin
M	0032200	biological_process	telomere organization
M	0032991	cellular_component	protein-containing complex
M	0040029	biological_process	epigenetic regulation of gene expression
M	0045296	molecular_function	cadherin binding
M	0046982	molecular_function	protein heterodimerization activity
M	0070062	cellular_component	extracellular exosome
N	0000781	cellular_component	chromosome, telomeric region
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006334	biological_process	nucleosome assembly
N	0016020	cellular_component	membrane
N	0030527	molecular_function	structural constituent of chromatin
N	0032200	biological_process	telomere organization
N	0032991	cellular_component	protein-containing complex
N	0043505	cellular_component	CENP-A containing nucleosome
N	0045653	biological_process	negative regulation of megakaryocyte differentiation
N	0046982	molecular_function	protein heterodimerization activity
N	0061644	biological_process	protein localization to CENP-A containing chromatin
N	0070062	cellular_component	extracellular exosome
O	0000786	cellular_component	nucleosome
O	0003674	molecular_function	molecular_function
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0008285	biological_process	negative regulation of cell population proliferation
O	0030527	molecular_function	structural constituent of chromatin
O	0031492	molecular_function	nucleosomal DNA binding
O	0031507	biological_process	heterochromatin formation
O	0046982	molecular_function	protein heterodimerization activity
O	0070062	cellular_component	extracellular exosome
P	0000786	cellular_component	nucleosome
P	0002227	biological_process	innate immune response in mucosa
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005829	cellular_component	cytosol
P	0006334	biological_process	nucleosome assembly
P	0019731	biological_process	antibacterial humoral response
P	0030527	molecular_function	structural constituent of chromatin
P	0042742	biological_process	defense response to bacterium
P	0042802	molecular_function	identical protein binding
P	0046982	molecular_function	protein heterodimerization activity
P	0050830	biological_process	defense response to Gram-positive bacterium
P	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
P	0070062	cellular_component	extracellular exosome
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0006325	biological_process	chromatin organization
Q	0006334	biological_process	nucleosome assembly
Q	0010467	biological_process	gene expression
Q	0016020	cellular_component	membrane
Q	0030527	molecular_function	structural constituent of chromatin
Q	0032200	biological_process	telomere organization
Q	0032991	cellular_component	protein-containing complex
Q	0040029	biological_process	epigenetic regulation of gene expression
Q	0045296	molecular_function	cadherin binding
Q	0046982	molecular_function	protein heterodimerization activity
Q	0070062	cellular_component	extracellular exosome
R	0000781	cellular_component	chromosome, telomeric region
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0006325	biological_process	chromatin organization
R	0006334	biological_process	nucleosome assembly
R	0016020	cellular_component	membrane
R	0030527	molecular_function	structural constituent of chromatin
R	0032200	biological_process	telomere organization
R	0032991	cellular_component	protein-containing complex
R	0043505	cellular_component	CENP-A containing nucleosome
R	0045653	biological_process	negative regulation of megakaryocyte differentiation
R	0046982	molecular_function	protein heterodimerization activity
R	0061644	biological_process	protein localization to CENP-A containing chromatin
R	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
O	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
N	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
M	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
P	ARG89-GLY111

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
M	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
M	ARG2
Q	ARG2

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692

Chain	Residue	Details
M	THR3
Q	THR3

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
M	LYS4
Q	LYS4
P	LYS12
P	LYS13
P	LYS17
P	LYS20
P	LYS40
P	LYS82

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
M	GLN5
Q	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
M	THR6
Q	THR6
N	LYS44
R	LYS8
R	LYS16
R	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
M	ARG8
Q	ARG8
N	LYS77
N	LYS91
R	LYS12
R	LYS31
R	LYS77
R	LYS91

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
M	LYS9
Q	LYS9

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
M	SER10
Q	SER10
P	LYS117

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803

Chain	Residue	Details
M	THR11
Q	THR11
O	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
M	LYS14
M	LYS56
Q	LYS14
Q	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635

Chain	Residue	Details
M	ARG17
Q	ARG17

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708

Chain	Residue	Details
M	LYS18
M	LYS64
Q	LYS18
Q	LYS64

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
M	LYS23
Q	LYS23

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Citrulline => ECO:0000269|PubMed:16567635

Chain	Residue	Details
M	ARG26
Q	ARG26

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708

Chain	Residue	Details
M	LYS27
Q	LYS27
R	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
M	SER28
Q	SER28
N	LYS79
R	LYS20
R	LYS59
R	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15983376, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708

Chain	Residue	Details
M	LYS36
Q	LYS36

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:15983376

Chain	Residue	Details
M	LYS37
Q	LYS37

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19783980

Chain	Residue	Details
M	TYR41
Q	TYR41

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
M	SER57
Q	SER57

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711

Chain	Residue	Details
M	LYS79
Q	LYS79

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
M	THR80
Q	THR80

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
M	SER86
Q	SER86

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
M	THR107
Q	THR107

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
M	LYS115
Q	LYS115

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
M	LYS122
Q	LYS122

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
M	LYS18
Q	LYS18

---