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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ONY

Human Methionine Aminopeptidase 2 at the 80S ribosome

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0004177molecular_functionaminopeptidase activity
A0004239molecular_functioninitiator methionyl aminopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006446biological_processregulation of translational initiation
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008235molecular_functionmetalloexopeptidase activity
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0046872molecular_functionmetal ion binding
A0070006molecular_functionmetalloaminopeptidase activity
LR0002181biological_processcytoplasmic translation
LR0003723molecular_functionRNA binding
LR0003735molecular_functionstructural constituent of ribosome
LR0005515molecular_functionprotein binding
LR0005730cellular_componentnucleolus
LR0005737cellular_componentcytoplasm
LR0005829cellular_componentcytosol
LR0005840cellular_componentribosome
LR0005925cellular_componentfocal adhesion
LR0006412biological_processtranslation
LR0006941biological_processstriated muscle contraction
LR0007283biological_processspermatogenesis
LR0016020cellular_componentmembrane
LR0022625cellular_componentcytosolic large ribosomal subunit
LR0022626cellular_componentcytosolic ribosome
LR0045202cellular_componentsynapse
LR1901740biological_processnegative regulation of myoblast fusion
LR1990904cellular_componentribonucleoprotein complex
LX0002181biological_processcytoplasmic translation
LX0003723molecular_functionRNA binding
LX0003735molecular_functionstructural constituent of ribosome
LX0005515molecular_functionprotein binding
LX0005634cellular_componentnucleus
LX0005730cellular_componentnucleolus
LX0005737cellular_componentcytoplasm
LX0005829cellular_componentcytosol
LX0005840cellular_componentribosome
LX0006412biological_processtranslation
LX0006941biological_processstriated muscle contraction
LX0007283biological_processspermatogenesis
LX0019843molecular_functionrRNA binding
LX0022625cellular_componentcytosolic large ribosomal subunit
LX0022626cellular_componentcytosolic ribosome
LX0045296molecular_functioncadherin binding
LX0070062cellular_componentextracellular exosome
LX1901740biological_processnegative regulation of myoblast fusion
LX1904841molecular_functionTORC2 complex binding
LX1990904cellular_componentribonucleoprotein complex
LY0002181biological_processcytoplasmic translation
LY0003723molecular_functionRNA binding
LY0003735molecular_functionstructural constituent of ribosome
LY0005515molecular_functionprotein binding
LY0005654cellular_componentnucleoplasm
LY0005730cellular_componentnucleolus
LY0005737cellular_componentcytoplasm
LY0005829cellular_componentcytosol
LY0005840cellular_componentribosome
LY0006364biological_processrRNA processing
LY0006412biological_processtranslation
LY0015934cellular_componentlarge ribosomal subunit
LY0016020cellular_componentmembrane
LY0022625cellular_componentcytosolic large ribosomal subunit
LY0022626cellular_componentcytosolic ribosome
LY0030330biological_processDNA damage response, signal transduction by p53 class mediator
LY0034644biological_processcellular response to UV
LY0042273biological_processribosomal large subunit biogenesis
LY0043517biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator
LY0045727biological_processpositive regulation of translation
LY0048027molecular_functionmRNA 5'-UTR binding
LY0070062cellular_componentextracellular exosome
LY0071480biological_processcellular response to gamma radiation
LY1902167biological_processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
LY1904803biological_processregulation of translation involved in cellular response to UV
LY1990904cellular_componentribonucleoprotein complex
Lh0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Lh0002181biological_processcytoplasmic translation
Lh0003723molecular_functionRNA binding
Lh0003729molecular_functionmRNA binding
Lh0003735molecular_functionstructural constituent of ribosome
Lh0005515molecular_functionprotein binding
Lh0005730cellular_componentnucleolus
Lh0005737cellular_componentcytoplasm
Lh0005829cellular_componentcytosol
Lh0005840cellular_componentribosome
Lh0006412biological_processtranslation
Lh0006941biological_processstriated muscle contraction
Lh0007283biological_processspermatogenesis
Lh0015934cellular_componentlarge ribosomal subunit
Lh0016020cellular_componentmembrane
Lh0022625cellular_componentcytosolic large ribosomal subunit
Lh0022626cellular_componentcytosolic ribosome
Lh1901740biological_processnegative regulation of myoblast fusion
Lh1990904cellular_componentribonucleoprotein complex
Lk0002181biological_processcytoplasmic translation
Lk0003723molecular_functionRNA binding
Lk0003735molecular_functionstructural constituent of ribosome
Lk0005515molecular_functionprotein binding
Lk0005737cellular_componentcytoplasm
Lk0005783cellular_componentendoplasmic reticulum
Lk0005829cellular_componentcytosol
Lk0005840cellular_componentribosome
Lk0005925cellular_componentfocal adhesion
Lk0006412biological_processtranslation
Lk0006941biological_processstriated muscle contraction
Lk0007283biological_processspermatogenesis
Lk0014069cellular_componentpostsynaptic density
Lk0022618biological_processprotein-RNA complex assembly
Lk0022625cellular_componentcytosolic large ribosomal subunit
Lk0022626cellular_componentcytosolic ribosome
Lk0033291cellular_componenteukaryotic 80S initiation complex
Lk0045202cellular_componentsynapse
Lk1901740biological_processnegative regulation of myoblast fusion
Lk1990904cellular_componentribonucleoprotein complex
Functional Information from PROSITE/UniProt
site_idPS00050
Number of Residues16
DetailsRIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLApdydaldV
ChainResidueDetails
LXLYS134-VAL149
site_idPS00526
Number of Residues20
DetailsRIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaSsvlrCGkkkVWLDP
ChainResidueDetails
LRGLN7-PRO26
site_idPS00579
Number of Residues15
DetailsRIBOSOMAL_L29 Ribosomal protein L29 signature. KLSKIRvVRKSIARV
ChainResidueDetails
LhLYS43-VAL57
site_idPS01108
Number of Residues19
DetailsRIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVqVVrGhyKGqqiGkV
ChainResidueDetails
LYASP52-VAL70
site_idPS01202
Number of Residues17
DetailsMAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD
ChainResidueDetails
AASP246-ASP262
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues57
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues10
DetailsCompositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Citrulline","evidences":[{"source":"UniProtKB","id":"P62751","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62751","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsModified residue: {"description":"Citrulline","evidences":[{"source":"UniProtKB","id":"P84099","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16134930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17350258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17636946","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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