8OHS

Core-binding domain of fungal E3-binding domain bound to the native pyruvate dehydrogenase E2 core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
A	0006090	biological_process	pyruvate metabolic process
A	0009060	biological_process	aerobic respiration
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0045254	cellular_component	pyruvate dehydrogenase complex
B	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
B	0006090	biological_process	pyruvate metabolic process
B	0009060	biological_process	aerobic respiration
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0045254	cellular_component	pyruvate dehydrogenase complex
C	0005198	molecular_function	structural molecule activity
C	0005739	cellular_component	mitochondrion
C	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
C	0009060	biological_process	aerobic respiration
C	0016746	molecular_function	acyltransferase activity
C	0045254	cellular_component	pyruvate dehydrogenase complex
D	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
D	0006090	biological_process	pyruvate metabolic process
D	0009060	biological_process	aerobic respiration
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0045254	cellular_component	pyruvate dehydrogenase complex
E	0005198	molecular_function	structural molecule activity
E	0005739	cellular_component	mitochondrion
E	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
E	0009060	biological_process	aerobic respiration
E	0016746	molecular_function	acyltransferase activity
E	0045254	cellular_component	pyruvate dehydrogenase complex
F	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
F	0006090	biological_process	pyruvate metabolic process
F	0009060	biological_process	aerobic respiration
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0045254	cellular_component	pyruvate dehydrogenase complex
G	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
G	0006090	biological_process	pyruvate metabolic process
G	0009060	biological_process	aerobic respiration
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0045254	cellular_component	pyruvate dehydrogenase complex
H	0005198	molecular_function	structural molecule activity
H	0005739	cellular_component	mitochondrion
H	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
H	0009060	biological_process	aerobic respiration
H	0016746	molecular_function	acyltransferase activity
H	0045254	cellular_component	pyruvate dehydrogenase complex
I	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
I	0006090	biological_process	pyruvate metabolic process
I	0009060	biological_process	aerobic respiration
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0045254	cellular_component	pyruvate dehydrogenase complex

Functional Information from PROSITE/UniProt

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdkFsagDVLleIETdKATmdVeaqddGvM

Chain	Residue	Details
C	GLY56-MET85
A	GLY59-LEU88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---