8OGI

Structure of native human eosinophil peroxidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress
A	0020037	molecular_function	heme binding
B	0004601	molecular_function	peroxidase activity
B	0006979	biological_process	response to oxidative stress
B	0020037	molecular_function	heme binding

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. ETPKLAAMHTL

Chain	Residue	Details
B	GLU380-LEU390

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00298

Chain	Residue	Details
B	THR306
B	PHE308
B	ASP310
B	SER312

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: covalent

Chain	Residue	Details
B	GLU380

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00298

Chain	Residue	Details
B	HIS474

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000255|PROSITE-ProRule:PRU00298

Chain	Residue	Details
B	ARG377

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:18694936

Chain	Residue	Details
B	TYR488

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN327
B	ASN363
B	ASN700
B	ASN708

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