8OFI
Ivabradine bound to HCN4 channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE623-GLY639 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 112 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 61 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 140 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 120 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 112 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 128 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y3Q4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
