8KG6

Yeast replisome in state I

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003682	molecular_function	chromatin binding
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005656	cellular_component	nuclear pre-replicative complex
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006271	biological_process	DNA strand elongation involved in DNA replication
2	0006279	biological_process	premeiotic DNA replication
2	0006974	biological_process	DNA damage response
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0031261	cellular_component	DNA replication preinitiation complex
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0043596	cellular_component	nuclear replication fork
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003688	molecular_function	DNA replication origin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005656	cellular_component	nuclear pre-replicative complex
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030466	biological_process	silent mating-type cassette heterochromatin formation
3	0031261	cellular_component	DNA replication preinitiation complex
3	0031509	biological_process	subtelomeric heterochromatin formation
3	0042555	cellular_component	MCM complex
3	0043596	cellular_component	nuclear replication fork
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
3	1904931	molecular_function	MCM complex binding
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003688	molecular_function	DNA replication origin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005656	cellular_component	nuclear pre-replicative complex
4	0005737	cellular_component	cytoplasm
4	0006260	biological_process	DNA replication
4	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0009378	molecular_function	four-way junction helicase activity
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0031261	cellular_component	DNA replication preinitiation complex
4	0033260	biological_process	nuclear DNA replication
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0043596	cellular_component	nuclear replication fork
4	0071162	cellular_component	CMG complex
4	0097373	cellular_component	MCM core complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003682	molecular_function	chromatin binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005656	cellular_component	nuclear pre-replicative complex
5	0005737	cellular_component	cytoplasm
5	0006260	biological_process	DNA replication
5	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0006368	biological_process	transcription elongation by RNA polymerase II
5	0008270	molecular_function	zinc ion binding
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0031261	cellular_component	DNA replication preinitiation complex
5	0031507	biological_process	heterochromatin formation
5	0031509	biological_process	subtelomeric heterochromatin formation
5	0033260	biological_process	nuclear DNA replication
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0043596	cellular_component	nuclear replication fork
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003688	molecular_function	DNA replication origin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005656	cellular_component	nuclear pre-replicative complex
6	0005737	cellular_component	cytoplasm
6	0005777	cellular_component	peroxisome
6	0006260	biological_process	DNA replication
6	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
6	0006270	biological_process	DNA replication initiation
6	0006271	biological_process	DNA strand elongation involved in DNA replication
6	0006279	biological_process	premeiotic DNA replication
6	0008270	molecular_function	zinc ion binding
6	0009378	molecular_function	four-way junction helicase activity
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0031261	cellular_component	DNA replication preinitiation complex
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0043596	cellular_component	nuclear replication fork
6	0071162	cellular_component	CMG complex
6	0097373	cellular_component	MCM core complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003688	molecular_function	DNA replication origin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005656	cellular_component	nuclear pre-replicative complex
7	0005737	cellular_component	cytoplasm
7	0006260	biological_process	DNA replication
7	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0008270	molecular_function	zinc ion binding
7	0009378	molecular_function	four-way junction helicase activity
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030466	biological_process	silent mating-type cassette heterochromatin formation
7	0031261	cellular_component	DNA replication preinitiation complex
7	0031509	biological_process	subtelomeric heterochromatin formation
7	0033260	biological_process	nuclear DNA replication
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0043596	cellular_component	nuclear replication fork
7	0071162	cellular_component	CMG complex
7	0097373	cellular_component	MCM core complex
7	1904931	molecular_function	MCM complex binding
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000811	cellular_component	GINS complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0031261	cellular_component	DNA replication preinitiation complex
A	0043596	cellular_component	nuclear replication fork
A	0071162	cellular_component	CMG complex
A	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
B	0000228	cellular_component	nuclear chromosome
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0031261	cellular_component	DNA replication preinitiation complex
B	0043596	cellular_component	nuclear replication fork
B	0071162	cellular_component	CMG complex
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000811	cellular_component	GINS complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006270	biological_process	DNA replication initiation
C	0031261	cellular_component	DNA replication preinitiation complex
C	0043596	cellular_component	nuclear replication fork
C	0071162	cellular_component	CMG complex
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0031261	cellular_component	DNA replication preinitiation complex
D	0043596	cellular_component	nuclear replication fork
D	0071162	cellular_component	CMG complex
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0003682	molecular_function	chromatin binding
E	0003688	molecular_function	DNA replication origin binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0031261	cellular_component	DNA replication preinitiation complex
E	0043596	cellular_component	nuclear replication fork
E	0071162	cellular_component	CMG complex
E	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
F	0000228	cellular_component	nuclear chromosome
F	0000278	biological_process	mitotic cell cycle
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0003682	molecular_function	chromatin binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006281	biological_process	DNA repair
F	0006334	biological_process	nucleosome assembly
F	0007064	biological_process	mitotic sister chromatid cohesion
F	0034085	biological_process	establishment of sister chromatid cohesion
F	0042802	molecular_function	identical protein binding
F	0043596	cellular_component	nuclear replication fork
G	0000228	cellular_component	nuclear chromosome
G	0000278	biological_process	mitotic cell cycle
G	0000727	biological_process	double-strand break repair via break-induced replication
G	0003682	molecular_function	chromatin binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0006260	biological_process	DNA replication
G	0006261	biological_process	DNA-templated DNA replication
G	0006270	biological_process	DNA replication initiation
G	0006281	biological_process	DNA repair
G	0006334	biological_process	nucleosome assembly
G	0007064	biological_process	mitotic sister chromatid cohesion
G	0034085	biological_process	establishment of sister chromatid cohesion
G	0042802	molecular_function	identical protein binding
G	0043596	cellular_component	nuclear replication fork
H	0000228	cellular_component	nuclear chromosome
H	0000278	biological_process	mitotic cell cycle
H	0000727	biological_process	double-strand break repair via break-induced replication
H	0003682	molecular_function	chromatin binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006260	biological_process	DNA replication
H	0006261	biological_process	DNA-templated DNA replication
H	0006270	biological_process	DNA replication initiation
H	0006281	biological_process	DNA repair
H	0006334	biological_process	nucleosome assembly
H	0007064	biological_process	mitotic sister chromatid cohesion
H	0034085	biological_process	establishment of sister chromatid cohesion
H	0042802	molecular_function	identical protein binding
H	0043596	cellular_component	nuclear replication fork
K	0000076	biological_process	DNA replication checkpoint signaling
K	0003674	molecular_function	molecular_function
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005829	cellular_component	cytosol
K	0006260	biological_process	DNA replication
K	0006281	biological_process	DNA repair
K	0006974	biological_process	DNA damage response
K	0007064	biological_process	mitotic sister chromatid cohesion
K	0008156	biological_process	negative regulation of DNA replication
K	0031297	biological_process	replication fork processing
K	0031298	cellular_component	replication fork protection complex
K	0043111	biological_process	replication fork arrest
K	0043570	biological_process	maintenance of DNA repeat elements
K	0043596	cellular_component	nuclear replication fork
K	0051321	biological_process	meiotic cell cycle
L	0000076	biological_process	DNA replication checkpoint signaling
L	0003674	molecular_function	molecular_function
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0006281	biological_process	DNA repair
L	0006974	biological_process	DNA damage response
L	0007064	biological_process	mitotic sister chromatid cohesion
L	0008156	biological_process	negative regulation of DNA replication
L	0031297	biological_process	replication fork processing
L	0031298	cellular_component	replication fork protection complex
L	0034087	biological_process	establishment of mitotic sister chromatid cohesion
L	0043111	biological_process	replication fork arrest
L	0043570	biological_process	maintenance of DNA repeat elements
L	0043596	cellular_component	nuclear replication fork
L	0045132	biological_process	meiotic chromosome segregation
L	0051321	biological_process	meiotic cell cycle
M	0000166	molecular_function	nucleotide binding
M	0000278	biological_process	mitotic cell cycle
M	0003676	molecular_function	nucleic acid binding
M	0003677	molecular_function	DNA binding
M	0003690	molecular_function	double-stranded DNA binding
M	0003697	molecular_function	single-stranded DNA binding
M	0003729	molecular_function	mRNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005657	cellular_component	replication fork
M	0006260	biological_process	DNA replication
M	0006261	biological_process	DNA-templated DNA replication
M	0006272	biological_process	leading strand elongation
M	0006281	biological_process	DNA repair
M	0006284	biological_process	base-excision repair
M	0006287	biological_process	base-excision repair, gap-filling
M	0006297	biological_process	nucleotide-excision repair, DNA gap filling
M	0006302	biological_process	double-strand break repair
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0007064	biological_process	mitotic sister chromatid cohesion
M	0008270	molecular_function	zinc ion binding
M	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
M	0008622	cellular_component	epsilon DNA polymerase complex
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0016787	molecular_function	hydrolase activity
M	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
M	0032183	molecular_function	SUMO binding
M	0033314	biological_process	mitotic DNA replication checkpoint signaling
M	0034061	molecular_function	DNA polymerase activity
M	0035822	biological_process	gene conversion
M	0042276	biological_process	error-prone translesion synthesis
M	0043596	cellular_component	nuclear replication fork
M	0045004	biological_process	DNA replication proofreading
M	0046872	molecular_function	metal ion binding
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
N	0003677	molecular_function	DNA binding
N	0003690	molecular_function	double-stranded DNA binding
N	0003697	molecular_function	single-stranded DNA binding
N	0003887	molecular_function	DNA-directed DNA polymerase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0006260	biological_process	DNA replication
N	0006261	biological_process	DNA-templated DNA replication
N	0008622	cellular_component	epsilon DNA polymerase complex
N	0030337	molecular_function	DNA polymerase processivity factor activity
N	0031981	cellular_component	nuclear lumen
N	0042276	biological_process	error-prone translesion synthesis
N	0043596	cellular_component	nuclear replication fork
N	0045005	biological_process	DNA-templated DNA replication maintenance of fidelity

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCLIDEFD

Chain	Residue	Details
2	GLY602-ASP610
4	GLY627-ASP635
5	GLY475-ASP483
6	GLY634-ASP642
3	GLY468-ASP476
7	GLY519-ASP527

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	621
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	120
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	25
Details	Zinc finger: {"description":"CysA-type","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	17
Details	Motif: {"description":"CysB motif","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14747467","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---