8KF5
The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0008201 | molecular_function | heparin binding |
| A | 0016020 | cellular_component | membrane |
| A | 0046914 | molecular_function | transition metal ion binding |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0008201 | molecular_function | heparin binding |
| B | 0016020 | cellular_component | membrane |
| B | 0046914 | molecular_function | transition metal ion binding |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| C | 0008201 | molecular_function | heparin binding |
| C | 0016020 | cellular_component | membrane |
| C | 0046914 | molecular_function | transition metal ion binding |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| D | 0008201 | molecular_function | heparin binding |
| D | 0016020 | cellular_component | membrane |
| D | 0046914 | molecular_function | transition metal ion binding |
| E | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| E | 0008201 | molecular_function | heparin binding |
| E | 0016020 | cellular_component | membrane |
| E | 0046914 | molecular_function | transition metal ion binding |
| F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| F | 0008201 | molecular_function | heparin binding |
| F | 0016020 | cellular_component | membrane |
| F | 0046914 | molecular_function | transition metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00280 |
| Number of Residues | 19 |
| Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FfyGGCggnrnnFdteeyC |
| Chain | Residue | Details |
| D | PHE-352-CYS-334 |
| site_id | PS00319 |
| Number of Residues | 8 |
| Details | APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP |
| Chain | Residue | Details |
| D | GLY-490-PRO-483 |
| site_id | PS00320 |
| Number of Residues | 8 |
| Details | APP_INTRA Amyloid precursor protein (APP) intracellular domain signature. GYENPTYK |
| Chain | Residue | Details |
| D | GLY85-LYS92 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 150 |
| Details | Peptide: {"description":"P3(42)","featureId":"PRO_0000000095"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 138 |
| Details | Peptide: {"description":"P3(40)","featureId":"PRO_0000000096"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Site: {"description":"Cleavage; by alpha-secretase","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Site: {"description":"Cleavage; by theta-secretase","evidences":[{"source":"PubMed","id":"16816112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Site: {"description":"Implicated in free radical propagation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Site: {"description":"Susceptible to oxidation","evidences":[{"source":"PubMed","id":"10535332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Site: {"description":"Cleavage; by gamma-secretase; site 1","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"O-linked (HexNAc...) tyrosine; partial","evidences":[{"source":"PubMed","id":"22576872","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
