8KEX

CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004930	molecular_function	G protein-coupled receptor activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006091	biological_process	generation of precursor metabolites and energy
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
E	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
E	0008218	biological_process	bioluminescence
E	0009055	molecular_function	electron transfer activity
E	0016020	cellular_component	membrane
E	0020037	molecular_function	heme binding
E	0022900	biological_process	electron transport chain
E	0038182	molecular_function	G protein-coupled bile acid receptor activity
E	0038184	biological_process	adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
E	0042597	cellular_component	periplasmic space
E	0160025	biological_process	sensory perception of itch

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TGLsMLSAISTERCLsV

Chain	Residue	Details
E	THR108-VAL124

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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