8KEX
CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0004930 | molecular_function | G protein-coupled receptor activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006091 | biological_process | generation of precursor metabolites and energy |
| E | 0007165 | biological_process | signal transduction |
| E | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| E | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| E | 0008218 | biological_process | bioluminescence |
| E | 0009055 | molecular_function | electron transfer activity |
| E | 0016020 | cellular_component | membrane |
| E | 0020037 | molecular_function | heme binding |
| E | 0022900 | biological_process | electron transport chain |
| E | 0038182 | molecular_function | G protein-coupled bile acid receptor activity |
| E | 0038184 | biological_process | adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway |
| E | 0042597 | cellular_component | periplasmic space |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0160025 | biological_process | sensory perception of itch |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TGLsMLSAISTERCLsV |
| Chain | Residue | Details |
| E | THR108-VAL124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 45 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
