8KER
Structure of SARS-CoV-2 XBB Variant Spike protein complexed with broadly neutralizing antibody PW5-535
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
Chain | Residue | Details |
H | TYR193-HIS199 | |
I | TYR201-HIS207 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
Chain | Residue | Details |
C | SER686 | |
A | SER686 | |
B | SER686 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
Chain | Residue | Details |
C | SER816 | |
A | SER816 | |
B | SER816 |
site_id | SWS_FT_FI3 |
Number of Residues | 15 |
Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | ASN62 | |
A | PHE1075 | |
B | ASN62 | |
B | ASN123 | |
B | PHE718 | |
B | PHE802 | |
B | PHE1075 | |
C | ASN123 | |
C | PHE718 | |
C | PHE802 | |
C | PHE1075 | |
A | ASN62 | |
A | ASN123 | |
A | PHE718 | |
A | PHE802 |
site_id | SWS_FT_FI4 |
Number of Residues | 9 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | ASN75 | |
C | LYS150 | |
C | GLU1195 | |
A | ASN75 | |
A | LYS150 | |
A | GLU1195 | |
B | ASN75 | |
B | LYS150 | |
B | GLU1195 |
site_id | SWS_FT_FI5 |
Number of Residues | 21 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | CYS166 | |
A | ILE332 | |
A | ALA344 | |
A | CYS617 | |
A | ASN658 | |
A | GLY1099 | |
B | CYS166 | |
B | GLY283 | |
B | ILE332 | |
B | ALA344 | |
B | CYS617 | |
C | GLY283 | |
B | ASN658 | |
B | GLY1099 | |
C | ILE332 | |
C | ALA344 | |
C | CYS617 | |
C | ASN658 | |
C | GLY1099 | |
A | CYS166 | |
A | GLY283 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | ILE235 | |
C | ASN710 | |
A | ILE235 | |
A | ASN710 | |
B | ILE235 | |
B | ASN710 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
Chain | Residue | Details |
C | GLU324 | |
A | GLU324 | |
B | GLU324 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
Chain | Residue | Details |
C | ILE326 | |
A | ILE326 | |
B | ILE326 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | THR604 | |
A | THR604 | |
B | THR604 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
Chain | Residue | Details |
C | GLN677 | |
C | LYS679 | |
A | GLN677 | |
A | LYS679 | |
B | GLN677 | |
B | LYS679 |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | ASN1135 | |
A | ASN1135 | |
B | ASN1135 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
C | HIS1159 | |
C | ALA1174 | |
A | HIS1159 | |
A | ALA1174 | |
B | HIS1159 | |
B | ALA1174 |