8KEH
State 2 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| G | TYR201-HIS207 | |
| F | TYR194-HIS200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| C | SER686 | |
| B | SER686 | |
| A | SER686 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| C | SER816 | |
| B | SER816 | |
| A | SER816 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | ASN62 | |
| B | PHE1075 | |
| A | ASN62 | |
| A | ASN123 | |
| A | PHE718 | |
| A | PHE802 | |
| A | PHE1075 | |
| C | ASN123 | |
| C | PHE718 | |
| C | PHE802 | |
| C | PHE1075 | |
| B | ASN62 | |
| B | ASN123 | |
| B | PHE718 | |
| B | PHE802 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | ASN75 | |
| C | LYS150 | |
| C | GLU1195 | |
| B | ASN75 | |
| B | LYS150 | |
| B | GLU1195 | |
| A | ASN75 | |
| A | LYS150 | |
| A | GLU1195 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | CYS166 | |
| B | ILE332 | |
| B | ALA344 | |
| B | CYS617 | |
| B | ASN658 | |
| B | GLY1099 | |
| A | CYS166 | |
| A | GLY283 | |
| A | ILE332 | |
| A | ALA344 | |
| A | CYS617 | |
| C | GLY283 | |
| A | ASN658 | |
| A | GLY1099 | |
| C | ILE332 | |
| C | ALA344 | |
| C | CYS617 | |
| C | ASN658 | |
| C | GLY1099 | |
| B | CYS166 | |
| B | GLY283 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | ILE235 | |
| C | ASN710 | |
| B | ILE235 | |
| B | ASN710 | |
| A | ILE235 | |
| A | ASN710 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| C | GLU324 | |
| B | GLU324 | |
| A | GLU324 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| C | ILE326 | |
| B | ILE326 | |
| A | ILE326 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | THR604 | |
| B | THR604 | |
| A | THR604 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| C | GLN677 | |
| C | LYS679 | |
| B | GLN677 | |
| B | LYS679 | |
| A | GLN677 | |
| A | LYS679 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | ASN1135 | |
| B | ASN1135 | |
| A | ASN1135 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | HIS1159 | |
| C | ALA1174 | |
| B | HIS1159 | |
| B | ALA1174 | |
| A | HIS1159 | |
| A | ALA1174 |
